Treating low back pain with combined cerebral and peripheral electrical stimulation: A randomized, double-blind, factorial clinical trial

AbstractAcute low back pain is a very common condition in Western industrialised countries. In most cases analgesics or topical medications are prescribed at first encounter with the general practitioner (GP).The aim of this study was to investigate whether the homeopathic gel Spiroflor SRL® gel (SRL) is equally effective and better tolerated than Cremor Capsici Compositus FNA (CCC) in patients with acute low back pain.A multi-centre, randomised, double-blind, controlled clinical trial was conducted in the practices of 19 GPs in the districts of Bristol and Manchester, UK. One hundred and sixty-one subjects suffering from acute low back pain were treated for one week either with SRL or with CCC. Pain was scored on a 100 mm visual analogue scale (VAS). Main efficacy parameter VAS reduction was compared between treatments. Evaluation of safety was primarily based on the number of subjects with adverse events (AEs), withdrawals due to an AE and adverse drug reactions (ADRs).The mean difference between the VAS reduction in the SRL group and the CCC group adjusted for VAS at baseline and age was −0.6 mm (90%CI=−6.5–5.3 mm). Fewer subjects in the SRL group (11%) experienced an AE than in the CCC group (26%). The same applies to the number of subjects with an ADR (3/81=4% vs 18/74=24%) and the number of subjects withdrawn due to an ADR (0/81=0% vs 8/74=11%).In conclusion, SRL and CCC are equally effective in the treatment of acute low back pain, however, SRL has a better safety profile. Spiroflor SRL® gel is preferable to Capsicum-based products for the topical treatment of low back pain, because of the lower risk of adverse effects.

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A double blind randomised controlled clinical trial on the effect of transcutaneous spinal electroanalgesia (TSE) on low back pain

European Journal of Pain ◽

10.1016/j.ejpain.2007.07.004 ◽

2008 ◽

Vol 12 (3) ◽

pp. 371-377 ◽

Cited By ~ 9

Author(s):

John W. Thompson ◽

Susanne Bower ◽

Stephen P. Tyrer

Keyword(s):

Clinical Trial ◽

Low Back Pain ◽

Back Pain ◽

Controlled Clinical Trial ◽

Low Back ◽

Double Blind ◽

Randomised Controlled Clinical Trial ◽

Randomised Controlled

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Efficacy of Steroid and Nonsteroid Caudal Epidural Injections for Low Back Pain and Sciatica: A Prospective, Randomized, Double-Blind Clinical Trial

Yearbook of Neurology and Neurosurgery ◽

10.1016/s0513-5117(10)79266-8 ◽

2010 ◽

Vol 2010 ◽

pp. 224-225

Author(s):

P.A. House

Keyword(s):

Clinical Trial ◽

Low Back Pain ◽

Back Pain ◽

Low Back ◽

Double Blind ◽

Epidural Injections ◽

Double Blind Clinical Trial ◽

Caudal Epidural

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Double-blind, randomized, double-dummy clinical trial comparing the efficacy of ketorolac trometamol and naproxen for acute low back pain

Drug Design Development and Therapy ◽

10.2147/dddt.s97756 ◽

2016 ◽

pp. 1987 ◽

Cited By ~ 6

Author(s):

Pérola Grinberg Plaper ◽

Morton Scheinberg ◽

Christina Ecclissato ◽

Monalisa Oliveira ◽

Roberto Amazonas

Keyword(s):

Clinical Trial ◽

Low Back Pain ◽

Back Pain ◽

Low Back ◽

Double Blind ◽

Acute Low Back Pain

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A double-blind, multicentre, randomised clinical trial comparing the efficacy and tolerability of aceclofenac with diclofenac resinate in patients with acute low back pain

Clinical Rheumatology ◽

10.1007/s10067-003-0710-9 ◽

2003 ◽

Vol 22 (2) ◽

pp. 127-135 ◽

Cited By ~ 25

Author(s):

M. Schattenkirchner ◽

K. A. Milachowski

Keyword(s):

Clinical Trial ◽

Low Back Pain ◽

Back Pain ◽

Randomised Clinical Trial ◽

Low Back ◽

Double Blind ◽

Acute Low Back Pain

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Effects of combining diaphragm training with electrical stimulation on pain, function, and balance in athletes with chronic low back pain: a randomized clinical trial

BMC Sports Science Medicine and Rehabilitation ◽

10.1186/s13102-021-00250-y ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Khadijeh Otadi ◽

Noureddin Nakhostin Ansari ◽

Shahriar Sharify ◽

Zahra Fakhari ◽

Hadi Sarafraz ◽

...

Keyword(s):

Clinical Trial ◽

Electrical Stimulation ◽

Low Back Pain ◽

Back Pain ◽

Dynamic Balance ◽

Static Stability ◽

Control Group ◽

Low Back ◽

Amateur Athletes ◽

Experimental Group

Abstract Background It is unknown how diaphragm training combined with electrical stimulation affects pain, function, static stability, and balance in athletes with chronic low back pain (CLBP). This study aimed to explore the effects of combining diaphragm training with electrical stimulation on pain, function, static stability, and dynamic balance in athletes with nonspecific CLBP. Methods The design was a randomized clinical trial. A total of 24 amateur athletes (12 women, 12 men, mean age: 35.2 ± 9.8) with nonspecific CLBP were randomly allocated into two groups. The experimental group (n = 12) received diaphragm training plus Transcutaneous Electrical Nerve Stimulation (TENS), while the control group (n = 12) received TENS alone. Both groups underwent 12 sessions over a four-week period. Static stability, dynamic balance, pain, and function were measured pre- and post-intervention. Results Analysis of variance 2 × 2 revealed greater improvements in pain (p < 0.001), static stability (p < 0.001), and dynamic balance (p < 0.01) in the experimental group compared to the control group. Function was improved in both groups following the interventions (p < 0.001), and there was a trend of a larger improvement in the experimental group than the control group (p = 0.09). Fisher’s exact test showed that the experimental group reported ≥50% improvement only in the pain score, not function, compared to the group that received TENS alone (p = 0.005). Conclusions Pain, function, static stability, and dynamic balance were improved in both groups following 12 intervention sessions. However, pain, static stability, and dynamic balance were improved to a greater extent in diaphragm training plus TENS than TENS alone in amateur athletes with CLBP. Therefore, it seems beneficial to add diaphragm training to the rehabilitation program for athletes with nonspecific CLBP. Trial registration The trial was retrospectively registered in the Iranian Registry of Clinical Trials (www.irct.ir) on September 10, 2020 as IRCT20090228001719N8.

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