Advanced electrolyte tuning and selectivity enhancement for highly sensitive analysis of cations by capillary ITP-ESI MS

2013 ◽  
Vol 34 (5) ◽  
pp. 777-784 ◽  
Author(s):  
Zdena Malá ◽  
Pavla Pantůčková ◽  
Petr Gebauer ◽  
Petr Boček
Keyword(s):  
Sensitive Analysis ◽  
Esi Ms ◽  
Highly Sensitive

scholarly journals Development of Highly Sensitive Analysis Method for Histamine and Metabolites in Pregnant Women’s Fingernail by UPLC-ESI-MS

2018 ◽  
Vol 34 (9) ◽  
pp. 1023-1029 ◽  
Author(s):  
Qingkun MA ◽  
Aoi UCHIBE ◽  
Qing SHI ◽  
Toshimasa TOYO’OKA ◽  
Chun-Yan XU ◽  
...  
Keyword(s):  
Analysis Method ◽  
Sensitive Analysis ◽  
Esi Ms ◽  
Highly Sensitive

scholarly journals Highly sensitive analysis of sterol profiles in human serum by LC-ESI-MS/MS

2008 ◽  
Vol 49 (9) ◽  
pp. 2063-2073 ◽  
Author(s):  
Akira Honda ◽  
Kouwa Yamashita ◽  
Hiroshi Miyazaki ◽  
Mutsumi Shirai ◽  
Tadashi Ikegami ◽  
...  
Keyword(s):  
Human Serum ◽  
Sensitive Analysis ◽  
Esi Ms ◽  
Highly Sensitive

A fully integrated microfluidic platform for highly sensitive analysis of immunochemical parameters

The Analyst ◽  
2017 ◽  
Vol 142 (22) ◽  
pp. 4206-4214 ◽  
Author(s):  
Sascha Lutz ◽  
Eloisa Lopez-Calle ◽  
Pamela Espindola ◽  
Christoph Boehm ◽  
Thorsten Brueckner ◽  
...  
Keyword(s):  
Cardiac Markers ◽  
Immunochemical Analysis ◽  
Sensitive Analysis ◽  
Microfluidic Platform ◽  
Fully Integrated ◽  
Highly Sensitive

A fully integrated cartridge for highly sensitive immunochemical analysis of cardiac markers with new microfluidic functionalities is presented.

Applications of Nanoparticles in Mass Spectrometry for Highly Sensitive Analysis

2015 ◽  
pp. 1-21
Author(s):  
Cuilan Chang ◽  
Jialing Zhang ◽  
Ze Li ◽  
Liping Li ◽  
Linnan Xu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Sensitive Analysis ◽  
Highly Sensitive

scholarly journals Development and Validation of UPLC-ESI-MS/MS Technique for the Determination of 2-Isopropyl-4-(chloromethyl)thiazole in Ritonavir

2020 ◽  
Vol 32 (7) ◽  
pp. 1733-1740
Author(s):  
K. Durga Raja ◽  
V. Saradhi Venkata Ramana ◽  
K. Raghu Babu ◽  
B. Kishore Babu ◽  
V. Jagadeesh Kumar ◽  
...  
Keyword(s):  
High Strength ◽  
Gradient Elution ◽  
Ultra Performance Liquid Chromatography ◽  
Internal Diameter ◽  
Esi Ms ◽  
Quantitation Limit ◽  
Highly Sensitive ◽  
Liquid Chromatography Tandem Mass ◽  
Development And Validation

The objective of this work was to develop and validate a rapid, highly sensitive ultra performance liquid chromatography-tandem mass spectrometry (UPLC-ESI-MS/MS) method for the quantification of 2-isopropyl-4-(chloromethyl)thiazole in ritonavir. Chromatographic conditions of this impurity were achieved on an AQUITY UPLC column HSS (high strength silica) T3 column (100 mm long, 2.1 mm internal diameter, 1.8 μm diameter) using a gradient elution with 0.1% formic acid in water and methanol at a flow rate of 0.3 mL/min. LCMS/MS was operated under the multiple reaction mode (MRM) using electrospray ionization technique in positive ion mode and the transitions of m/z 176.1[M+H]+→140.1 for quantifier, 176.1[M+H]+→71.0 for qualifier were used to measure the impurity, respectively. The total chromatographic run time was 10 min. Full validation of the analytical method was carried out, including its system precision, selectivity, linearity, accuracy, recovery, ruggedness, stability and robustness. A linear response function was achieved in the concentration range of 0.12-1.86 μg/g with r > 0.99. The detection limit and quantitation limit of this impurity were 0.06 and 0.12 μg/g, respectively. Consistent recoveries were obtained during intra- and inter-day precision experiments in validation ranged from 80-120%. The developed method could be helpful not only for quality control and also for risk management of potential genotoxicity of this impurity in ritonavir drug substance.

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