Enhanced extraction of 3-demethylated colchicine from fermentation broth of Bacillus megaterium: Optimization of process parameters by statistical experimental design

2011 ◽  
Vol 11 (6) ◽  
pp. 598-606 ◽  
Author(s):  
Kashyap K. Dubey ◽  
Arshad Jawed ◽  
Shafiul Haque
Keyword(s):  
Experimental Design ◽  
Process Parameters ◽  
Bacillus Megaterium ◽  
Fermentation Broth ◽  
Statistical Experimental Design ◽  
Optimization Of Process Parameters

scholarly journals Optimization of process parameters using response surface methodology for the removal of phenol by emulsion liquid membrane

2012 ◽  
Vol 14 (1) ◽  
pp. 46-49 ◽  
Author(s):  
A. Balasubramanian ◽  
S. Venkatesan
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Process Parameters ◽  
Surfactant Concentration ◽  
Liquid Membrane ◽  
Phase Ratio ◽  
Phenol Removal ◽  
Statistical Experimental Design ◽  
Emulsion Liquid Membrane ◽  
Optimization Of Process Parameters

Optimization of process parameters using response surface methodology for the removal of phenol by emulsion liquid membrane Emulsion liquid membrane technique (ELM) was used for the extraction of phenol from synthetic and industrial effluents. In this study, the liquid membrane used for phenol removal was composed of kerosene as the solvent, Span-80 as the surfactant and Sodium hydroxide as an internal reagent. Statistical experimental design was applied for the optimization of process parameters for the removal of phenol by ELM. The effects of process parameters namely, Surfactant concentration, membrane or organic to internal phase ratio (M/I) and emulsion to an external phase ratio (E/E) on the removal of phenol were optimized using a response surface method. The optimum conditions for the extraction of phenol using Response surface methodology were: surfactant concentration - 4.1802%, M/I ratio: 0.9987(v/v), and E/E ratio: 0.4718 (v/v). Under the optimized condition the maximum phenol extraction was found to be 98.88% respectively.

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