The Lipid-based drug delivery system is extensively reported within the literature for the enhancing drug solubility, permeability, and
bioavailability. A considerable majority of novel pharmacologically active constituents produced in recent drug discovery programs
are lipophilic and poorly soluble, posing a significant problem for pharmaceutical researchers enhancing the oral bioavailability of
such drug molecules. Self-nano emulsifying drug delivery systems (SNEDDS), are the viable oil-based approaches for drugs that exhibit
low dissolution rate and inadequate absorption. Ever since the progress of SNEDDS, researchers have been focusing on the challenges
of BCS Class II and Class IV Drugs for enhancing water Solubility of poorly water-soluble drugs. SNEDDS is a Validate method for
enhancing the solubility and bioavailability of lipophilic compounds. It’s the isotropic mixture of oil, surfactant, co-surfactant
molecules and it also containing co-solvent molecule. which spontaneously form oil-in-water nano emulsion of approximately 200
nm or less in size upon dilution with water under gentle stirring. It’s Drug delivery system Which possess thermodynamically and
kinetically stability. The physicochemical properties, drug solubilization capacity considerably regulates the selection of the SNEDDS
components. The compositions of the SNEDDS are often optimized with the assistance of phase diagrams. Further to optimize SNEDDS
can be done with the help of statistical experimental design. It’s a Novel drug delivery system which is applicable for the parenteral,
Ophthalmic, intranasal and cosmetic drug delivery system. And therefore, the present review describes Preparation, components,
mechanism of self-Nano emulsification, biopharmaceutical aspects, characterization methods and applications of Selfnanoemulsifying drug delivery system (SNEDDS).