Genotoxicity of occupational exposure to wood dust: Micronucleus frequency and nuclear changes in exfoliated buccal mucosa cells

2006 ◽  
Vol 47 (9) ◽  
pp. 693-698 ◽  
Author(s):  
Ayla Çelik ◽  
Arzu Kanık
2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hauke Reimann ◽  
Helga Stopper ◽  
Thomas Polak ◽  
Martin Lauer ◽  
Martin J. Herrmann ◽  
...  

AbstractNeurodegenerative diseases show an increase in prevalence and incidence, with the most prominent example being Alzheimer’s disease. DNA damage has been suggested to play a role in the pathogenesis, but the exact mechanisms remain elusive. We enrolled 425 participants with and without neurodegenerative diseases and analyzed DNA damage in the form of micronuclei in buccal mucosa samples. In addition, other parameters such as binucleated cells, karyolytic cells, and karyorrhectic cells were quantified. No relevant differences in DNA damage and cytotoxicity markers were observed in patients compared to healthy participants. Furthermore, other parameters such as lifestyle factors and diseases were also investigated. Overall, this study could not identify a direct link between changes in buccal cells and neurogenerative diseases, but highlights the influence of lifestyle factors and diseases on the human buccal cytome.


2010 ◽  
Vol 9 (3) ◽  
pp. 1921-1928 ◽  
Author(s):  
L.N. Rickes ◽  
M.C. Alvarengo ◽  
T.M. Souza ◽  
G.L. Garcias ◽  
M.G. Martino-Roth

Astrocyte ◽  
2015 ◽  
Vol 1 (4) ◽  
pp. 288
Author(s):  
Nilima Sawke ◽  
Gopalkrishna Sawke ◽  
D Parmar

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