scholarly journals Chemical characterization of balloon flower ( Platycodon grandiflorum ) sprout extracts and their regulation of inflammatory activity in lipopolysaccharide‐stimulated RAW 264.7 murine macrophage cells

2019 ◽  
Vol 8 (1) ◽  
pp. 246-256 ◽  
Author(s):  
Mina Kim ◽  
In‐Guk Hwang ◽  
Sang‐Bum Kim ◽  
Ae‐Jin Choi
2007 ◽  
Vol 36 (2) ◽  
pp. 203-211 ◽  
Author(s):  
Thongchai Taechowisan ◽  
Pittaya Tuntiwachwuttikul ◽  
Chunhua Lu ◽  
Yuemao Shen ◽  
Saisamorn Lumyong ◽  
...  

Author(s):  
Chun Whan Choi ◽  
Ju Young Shin ◽  
Changon Seo ◽  
Seong Su Hong ◽  
Eun-Kyung Ahn ◽  
...  

Author(s):  
Chun Whan Choi ◽  
Ju Young Shin ◽  
Changon Seo ◽  
Seong Su Hong ◽  
Eun-Kyung Ahn ◽  
...  

Background: Plants still remain the prime source of drugs for the treatment of inflammation and can provide leads for the development of novel anti-inflammatory agents. Material and methods: An in vitro bioassay guide revealed that the 80% ethanol (EtOH) extract of the whole plant, Amomum tsao-ko (Zingiberaceae), displayed anti-inflammatory activity after assessing its effects on murine macrophage RAW 264.7 cells. Result: Phytochemical study of the 80% EtOH extract of Amomum tsao-ko led to the isolation of eight compounds: 4-hydroxy-3-methoxy-benzoic acid (1), meso-hannokinol (2), (+)-hannokinol (3), coumaric acid (4), 4-hydroxy-benzoic acid (5), (+)-epicatechin (6), (-)-catechin (7), and myrciaphenone A (8). The results indicated that two of the isolated components, (+)-epicatechin (6) and (-)-catechin (7), inhibited the production of nitric oxide (NO) significantly in lipopolysaccharide treated RAW 264.7 cells. Conclusion: LPS-induced interleukin tumor necrosis factor-alpha (TNF-), IL-1β and IL-10 production was also decreased in a dose-dependent manner. In addition, western blot analysis revealed that (+)-epicatechin (6) and (-)-catechin (7) reduced the expression of inducible nitric oxide synthase and inhibited nuclear localization of nuclear factor kappa-B (NF-κB).


2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Amy Seewald ◽  
Fatima Pina ◽  
Kandice Beverly ◽  
Brenda Jane Smith ◽  
Edralin Lucas

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