Determination of the origin and nature of brain macrophages and microglial cells in mouse central nervous system, using non-radioactive in situ hybridization and immunoperoxidase techniques

Glia ◽  
1992 ◽  
Vol 6 (4) ◽  
pp. 301-309 ◽  
Author(s):  
Corline J. A. De Groot ◽  
Wim Huppes ◽  
Taede Sminia ◽  
Georg Kraal ◽  
Christine D. Dijkstra
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
In Situ Hybridization ◽  
Microglial Cells ◽  
Brain Macrophages ◽  
Mouse Central Nervous System

scholarly journals Apoptotic Cells, Including Macrophages, Are Prominent in Theiler's Virus-Induced Inflammatory, Demyelinating Lesions

2003 ◽  
Vol 77 (7) ◽  
pp. 4383-4388 ◽  
Author(s):  
Brian P. Schlitt ◽  
Matthew Felrice ◽  
Mary Lou Jelachich ◽  
Howard L. Lipton
Keyword(s):  
Central Nervous System ◽  
T Cells ◽  
Nervous System ◽  
In Situ Hybridization ◽  
Apoptotic Cells ◽  
Theiler's Virus ◽  
Demyelinating Lesions ◽  
Encephalomyelitis Virus ◽  
Mouse Central Nervous System

ABSTRACT Theiler's murine encephalomyelitis virus (TMEV) persists in the mouse central nervous system principally in macrophages, and infected macrophages in culture undergo apoptosis. We have detected abundant apoptotic cells in perivascular cuffs and inflammatory, demyelinating lesions of SJL mice chronically infected with TMEV. T cells comprised 74% of apoptotic cells, while 8% were macrophages, 0.6% were astrocytes, and ∼17% remained unidentified. In situ hybridization revealed viral RNA in ∼1% of apoptotic cells.

scholarly journals In situ hybridization for the detection of Epstein–Barr virus in central nervous system lymphomas

Cancer ◽  
1991 ◽  
Vol 67 (2) ◽  
pp. 444-448 ◽  
Author(s):  
Raouf E. Nakhleh ◽  
J. Carlos Manivel ◽  
Cedith M. Copenhaver ◽  
Joo H. Sung ◽  
John G. Strickler
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
In Situ Hybridization ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr
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