Anxiety and behavioural disturbance as markers of prodromal Alzheimer's disease in patients with mild cognitive impairment

2011 ◽  
Vol 26 (2) ◽  
pp. 166-172 ◽  
Author(s):  
Damien Gallagher ◽  
Robert Coen ◽  
Dana Kilroy ◽  
Kate Belinski ◽  
Irene Bruce ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Behavioural Disturbance ◽  
Prodromal Alzheimer’S Disease

scholarly journals Event-related potential and EEG oscillatory predictors of verbal memory in mild cognitive impairment

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Jiangyi Xia ◽  
Ali Mazaheri ◽  
Katrien Segaert ◽  
David P Salmon ◽  
Danielle Harvey ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Verbal Memory ◽  
Verbal Learning ◽  
Event Related Potential ◽  
Single Trial ◽  
Prodromal Alzheimer’S Disease ◽  
Alpha Beta

Abstract Reliable biomarkers of memory decline are critical for the early detection of Alzheimer’s disease. Previous work has found three EEG measures, namely the event-related brain potential P600, suppression of oscillatory activity in the alpha frequency range (∼10 Hz) and cross-frequency coupling between low theta/high delta and alpha/beta activity, each of which correlates strongly with verbal learning and memory abilities in healthy elderly and patients with mild cognitive impairment or prodromal Alzheimer’s disease. In the present study, we address the question of whether event-related or oscillatory measures, or a combination thereof, best predict the decline of verbal memory in mild cognitive impairment and Alzheimer’s disease. Single-trial correlation analyses show that despite a similarity in their time courses and sensitivities to word repetition, the P600 and the alpha suppression components are minimally correlated with each other on a trial-by-trial basis (generally |rs| < 0.10). This suggests that they are unlikely to stem from the same neural mechanism. Furthermore, event-related brain potentials constructed from bandpass filtered (delta, theta, alpha, beta or gamma bands) single-trial data indicate that only delta band activity (1–4 Hz) is strongly correlated (r = 0.94, P < 0.001) with the canonical P600 repetition effect; event-related potentials in higher frequency bands are not. Importantly, stepwise multiple regression analyses reveal that the three event-related brain potential/oscillatory measures are complementary in predicting California Verbal Learning Test scores (overall R2’s in 0.45–0.63 range). The present study highlights the importance of combining EEG event-related potential and oscillatory measures to better characterize the multiple mechanisms of memory failure in individuals with mild cognitive impairment or prodromal Alzheimer’s disease.

O5-05-06: GENETIC AND EPIGENETIC BLOOD SIGNATURE OF MILD COGNITIVE IMPAIRMENT IN PRODROMAL ALZHEIMER'S DISEASE

2014 ◽  
Vol 10 ◽  
pp. P301-P301
Author(s):  
Yvon Chagnon ◽  
Guylaine Ferland ◽  
Sylvie Belleville ◽  
José A. Morais ◽  
Hélène Payette ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Prodromal Alzheimer’S Disease

scholarly journals Mild Cognitive Impairment: Prodromal Alzheimer's Disease or Something Else?

2011 ◽  
Vol 27 (3) ◽  
pp. 543-551 ◽  
Author(s):  
William G. Britt III ◽  
Anne M. Hansen ◽  
Sofia Bhaskerrao ◽  
James P. Larsen ◽  
Floyd Petersen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Prodromal Alzheimer’S Disease

Cognitive Decline in Adults with Amnestic Mild Cognitive Impairment and High Amyloid-β: Prodromal Alzheimer's Disease?

2013 ◽  
Vol 33 (4) ◽  
pp. 1167-1176 ◽  
Author(s):  
Yen Ying Lim ◽  
Kathryn A. Ellis ◽  
Karra Harrington ◽  
Robert H. Pietrzak ◽  
Joanne Gale ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Decline ◽  
Amyloid Β ◽  
Amnestic Mild Cognitive Impairment ◽  
Prodromal Alzheimer’S Disease
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