scholarly journals Surface-based vertexwise analysis of morphometry and microstructural integrity for white matter tracts in diffusion tensor imaging: With application to the corpus callosum in Alzheimer's disease

2017 ◽  
Vol 38 (4) ◽  
pp. 1875-1893 ◽  
Author(s):  
Xiaoying Tang ◽  
Yuanyuan Qin ◽  
Wenzhen Zhu ◽  
Michael I. Miller
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Corpus Callosum ◽  
Diffusion Tensor ◽  
White Matter Tracts ◽  
Microstructural Integrity

scholarly journals The use of diffusion-tensor imaging to assess microstructural integrity of white matter of patients with Alzheimer’s disease

2019 ◽  
Vol 99 (6) ◽  
pp. 295-304
Author(s):  
V. A. Perepelov ◽  
V. I. Solodovnikov ◽  
V. E. Sinitsyn ◽  
E. M. Perepelova ◽  
N. N. Koberskaya ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Small Vessel Disease ◽  
Posterior Part ◽  
Mean Diffusivity ◽  
Imaging Protocol ◽  
Microstructural Integrity

Objective. To compare diffusion-tensor imaging (DTI) measures in different anatomic regions of the brain in patients with an isolated Alzheimer's disease (AD) and patients with AD and small-vessel disease (SVD).Material and methods. 20 AD patients, aged 66 (±10), of whom 11 AD patients had an isolated neurodegenerative process and 9 patients, who were diagnosed with AD+SVD, were examined. A research was made on a 3 T Siemens Magnetom Skyra MR-scanner. All participants underwent the same imaging protocol, which included standard clinical- and diffusion tensor pulse sequences. With an MR-image processing software package Olea Medical Sphere 3.0, fractional anisotropy (FA), mean diffusivity (MD), axial and radial diffusivity (AxD and RxD) were measured in different brain regions.Results. Significant differences in DTI measures (FA, MD, AxD, RxD), indicating more severe white matter microstructural damage in AD+SVD patients, compared with patients with an isolated AD, were observed in middle thalamic radiation, upper and lower longitudinal bundles, posterior part of cingulate gyrus and genu of corpus callosum.Conclusion. DTI is an informative method, highly sensitive in detecting difference in white matter microstructural integrity of brain tissue in individuals with an isolated AD and patients with AD+SVD.

Short-term white matter alterations in Alzheimer's disease characterized by diffusion tensor imaging

2015 ◽  
Vol 43 (3) ◽  
pp. 627-634 ◽  
Author(s):  
Sila Genc ◽  
Christopher E Steward ◽  
Charles B Malpas ◽  
Dennis Velakoulis ◽  
Terence J O'Brien ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Short Term

IC-P-114: Improved classification of MCI and Alzheimer's disease using diffusion tensor imaging of cingulum white matter

2006 ◽  
Vol 2 ◽  
pp. S697-S698
Author(s):  
Michael W. Weiner ◽  
Yu Zhang ◽  
Geon-Ho Jahng ◽  
Bayne Whitney ◽  
Susumu Mori ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor
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