Evaluation and validation of Physiological and Operative Severity Score for the enumeration of mortality and morbidity and
            Portsmouth‐POSSUM
            scores in predicting morbidity and mortality in patients undergoing head and neck cancer surgeries

Head and neck cancer (HNC) is a complex and heterogeneous disease associated with high mortality and morbidity worldwide. Standard therapeutic management of advanced HNC, which is based on radiotherapy often combined with chemotherapy, has been hampered by severe long-term side effects. To overcome these side effects, tumor-selective nanoparticles have been exploited as a potential drug delivery system to improve HNC therapy. A combination of MEDLINE, EMBASE, Cochrane Oral Health Group’s Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL) and ClinicalTrials.gov from inception up to June 2020 was used for this systematic review. A total of 1747 published manuscripts were reviewed and nine relevant references were retrieved for analysis, while eight of them were eligible for meta-analysis. Based on these studies, the level of evidence about the efficacy of nanoformulation for HNC therapy on tumor response and adverse side effects (SAE) was low. Even though basic research studies have revealed a greater promise of nanomaterial to improve the outcome of cancer therapy, none of them were translated into clinical benefits for HNC patients. This systematic review summarized and discussed the recent progress in the development of targeted nanoparticle approaches for HNC management, and open-up new avenues for future perspectives.

Download Full-text

The role of infection in the morbidity and mortality of patients with head and neck cancer undergoing multimodality therapy

Cancer ◽

10.1002/1097-0142(19910201)67:3<716::aid-cncr2820670331>3.0.co;2-j ◽

1991 ◽

Vol 67 (3) ◽

pp. 716-721 ◽

Cited By ~ 37

Author(s):

Maha Hussain ◽

Julie A. Kish ◽

Lawrence Crane ◽

Ahmed Uwayda ◽

Glen Cummings ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Multimodality Therapy ◽

Morbidity And Mortality

Download Full-text

Management of vascular complications of head and neck cancer

The Journal of Laryngology & Otology ◽

10.1017/s0022215111002416 ◽

2011 ◽

Vol 126 (2) ◽

pp. 111-115 ◽

Cited By ~ 8

Author(s):

J Rimmer ◽

C E B Giddings ◽

F Vaz ◽

J Brooks ◽

C Hopper

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Case Reports ◽

High Risk Patient ◽

Vascular Complications ◽

Morbidity And Mortality ◽

Illustrative Case ◽

Life Threatening ◽

Radiation Induced

AbstractBackground:Major vascular complications in patients with head and neck cancer have previously been thought of as terminal events. However, it is now possible to intervene in many situations, with benefits for quality of life as well as survival. Endovascular techniques have reduced morbidity and mortality in many situations, both emergency and elective.Method:We describe the techniques that can be employed in such situations, and present illustrative case reports. Life-threatening haemorrhage, carotid compression and radiation-induced carotid stenosis are all discussed.Conclusion:It is possible to predict where complications may arise, and to take prophylactic steps to allow treatment to continue. Early intervention can reduce both morbidity and mortality in this high-risk patient group.

Download Full-text

Nutritional Assessment of the Head and Neck Cancer Patient

Otolaryngology ◽

10.1177/019459988008800613 ◽

1980 ◽

Vol 88 (6) ◽

pp. 695-699 ◽

Cited By ~ 4

Author(s):

Matthew J. Lambert

Keyword(s):

Radiation Therapy ◽

Head And Neck Cancer ◽

Cancer Patient ◽

Head And Neck ◽

Neck Cancer ◽

Nutritional Support ◽

Nutritional Assessment ◽

Nutritional Deficiency ◽

Neck Cancer Patient ◽

Morbidity And Mortality

Malnutrition is a common problem in patients with head and neck cancer. Its presence may lead to an increase in morbidity and mortality following an operation, chemotherapy, and radiation therapy. A standard nutritional assessment will define the nature and degree of the nutritional deficiency while periodic reassessment will document the effects of nutritional support.

Download Full-text