An comparison of acute toxicities and patient‐reported outcomes between intensity‐modulated proton therapy and volumetric‐modulated arc therapy after ipsilateral radiation for head and neck cancers

Head & Neck ◽  
2021 ◽  
Author(s):  
Elizabeth B. Jeans ◽  
Satomi Shiraishi ◽  
Gohar Manzar ◽  
Lindsay K. Morris ◽  
Adam Amundson ◽  
...  
Keyword(s):  
Head And Neck ◽  
Proton Therapy ◽  
Patient Reported Outcomes ◽  
Volumetric Modulated Arc Therapy ◽  
Head And Neck Cancers ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated ◽  
Patient Reported ◽  
Arc Therapy

scholarly journals Patient-Reported Outcomes after Intensity-Modulated Proton Therapy for Oropharynx Cancer

2021 ◽  
Vol 8 (1) ◽  
pp. 213-222
Author(s):  
Houda Bahig ◽  
Brandon G. Gunn ◽  
Adam S. Garden ◽  
Rong Ye ◽  
Kate Hutcheson ◽  
...  
Keyword(s):  
Head And Neck ◽  
Proton Therapy ◽  
Patient Reported Outcomes ◽  
Mixed Model ◽  
Locally Advanced ◽  
Well Being ◽  
Intensity Modulated Proton Therapy ◽  
Oropharynx Cancer ◽  
Intensity Modulated ◽  
Patient Reported

Abstract Purpose To report patient-reported outcomes (PROs) derived from the Functional Assessment of Cancer Therapy-Head and Neck (FACT-HN) tool, in patients with oropharynx cancer (OPC) treated with intensity-modulated proton therapy (IMPT) in the context of first-course irradiation. Materials and Methods Patients with locally advanced OPC treated with radical IMPT between 2011 and 2018 were included in a prospective registry. FACT-HN scores were measured serially during and 24 months following IMPT. PRO changes in the FACT-HN scores over time were assessed with mixed-model analysis. Results Fifty-seven patients met inclusion criteria. Median age was 60 years (range, 41-84), and 91% had human papillomavirus-associated disease. In total, 28% received induction chemotherapy and 68% had concurrent chemotherapy. Compliance to FACT-HN questionnaire completion was 59%, 48%, and 42% at 6, 12, and 24 months after treatment, respectively. The mean FACT-General (G), FACT-Total, and FACT-Trial Outcome Index (TOI) score changes were statistically and clinically significant relative to baseline from week 3 of treatment up to week 2 after treatment. Nadir was reached at week 6 of treatment for all scores, with maximum scores dropping by 15%, 20%, and 39% compared to baseline for FACT-G, FACT-Total, and FACT-TOI, respectively. Subdomain scores of physical well-being, functional well-being, and head and neck additional concerns decreased from baseline during treatment and returned to baseline at week 4 after treatment. Conclusions IMPT was associated with a favorable PRO trajectory, characterized by an acute decline followed by rapid recovery to baseline. This study establishes the expected acute, subacute, and chronic trajectory of PROs for patients undergoing IMPT for OPC.

PO-0930 ROBUSTNESS OF IMPT (INTENSITY MODULATED PROTON THERAPY) COMPARED WITH IMRT FOR HEAD AND NECK CANCERS

2012 ◽  
Vol 103 ◽  
pp. S366-S367
Author(s):  
R. Harding ◽  
J. Lilley ◽  
V.P. Cosgrove ◽  
S.J. Weston ◽  
C.M. Thompson ◽  
...  
Keyword(s):  
Head And Neck ◽  
Proton Therapy ◽  
Head And Neck Cancers ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated

Prospective longitudinal patient-reported outcomes of swallowing following intensity modulated proton therapy for oropharyngeal cancer

2020 ◽  
Vol 148 ◽  
pp. 133-139 ◽  
Author(s):  
Stephen R. Grant ◽  
Katherine A. Hutcheson ◽  
Rong Ye ◽  
Adam S. Garden ◽  
William H. Morrison ◽  
...  
Keyword(s):  
Proton Therapy ◽  
Oropharyngeal Cancer ◽  
Patient Reported Outcomes ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated ◽  
Patient Reported ◽  
Prospective Longitudinal
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