A Combination of Chenodeoxycholic Acid and Ursodeoxycholic Acid is more Effective than Either Alone in Reducing Biliary Cholesterol Saturation

Three groups of golden Syrian hamsters were fed equimolar amounts of taurine-conjugated ursodeoxycholic acid (TUDCA) or unconjugated ursodeoxycholic acid (UDCA) with or without excess taurine for 2 wk. They also received a lithogenic diet composed of standard rodent chow containing ethynylestradiol and increased cholesterol. Bile was obtained from the gallbladder after ketamine anesthesia and analyzed for biliary lipids. The percentage of biliary UDCA was higher with TUDCA (38.5 +/- 3.7) than with UDCA plus taurine (26.5 +/- 2.0, P less than 0.01). The glycine-to-taurine ratio of biliary UDCA conjugates was lower with TUDCA (0.9 +/- 0.1) than with UDCA plus taurine (2.1 +/- 0.2, P less than 0.01) and was highest with UDCA without taurine (4.1 +/- 0.1, P less than 0.01). Biliary cholesterol (molar percentage) and the cholesterol saturation indices with or without correction for UDCA-rich bile were significantly lower with TUDCA than with unconjugated UDCA with or without added taurine. In conclusion, administration for 2 wk of TUDCA, compared with an equimolar amount of unconjugated UDCA plus taurine, produced in the bile of hamsters a higher percentage of UDCA, a lower glycine-to-taurine ratio of UDCA conjugates, and a lower saturation index before and after adjustment for UDCA-rich bile.

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Ursodeoxycholic Acid (UDCA) Therapy of Gallstones. is Correction of Biliary Cholesterol Saturation Index According to Percentage UDCA in Bile Necessary for Prediction of Gallstone Dissolution?

Clinical Science ◽

10.1042/cs057026pb ◽

1979 ◽

Vol 57 (3) ◽

pp. 26P-27P ◽

Cited By ~ 3

Author(s):

G. Williams ◽

N. Tanida ◽

P. N. Maton ◽

G. M. Murphy ◽

R. H. Dowling

Keyword(s):

Ursodeoxycholic Acid ◽

Saturation Index ◽

Biliary Cholesterol ◽

Gallstone Dissolution ◽

Cholesterol Saturation ◽

Cholesterol Saturation Index

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Pregnancy and the Biliary System

Canadian Journal of Gastroenterology ◽

10.1155/1990/582650 ◽

1990 ◽

Vol 4 (5) ◽

pp. 209-214 ◽

Cited By ~ 2

Author(s):

Helga Witt ◽

J Joseph Connon

Keyword(s):

Pregnant Women ◽

Chenodeoxycholic Acid ◽

Bile Salts ◽

Second Trimester ◽

Biliary Cholesterol ◽

Ratio Increase ◽

Gallbladder Function ◽

Gallbladder Contractility ◽

Cholesterol Saturation ◽

Acid Ratio

Alterations in the synthesis and secretion of bile salts and cholesterol and in gallbladder function occur during pregnancy. These changes are related to the effects of estrogen and progesterone. Biliary cholesterol saturation and the cholic acid/chenodeoxycholic acid ratio increase. Progesterone also diminishes gallbladder contractility and emptying. Gallstones occur in 2.5 to 11% of pregnant women and are associated with cholecystitis in 0.008 to 0.1% of pregnant women. Operative treatment should be deferred if possible until after delivery; failing that, surgery is best done in the second trimester. Endoscopic pap1llotomy may prove to be the best therapy for choledocholithiasis.

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Effect of Chenodeoxycholic Acid on Serum and Biliary Lipids in Patients with Hyperlipoproteinaemia

Clinical Science ◽

10.1042/cs0540451 ◽

1978 ◽

Vol 54 (4) ◽

pp. 451-455 ◽

Cited By ~ 1

Author(s):

B. Angelin ◽

K. Einarsson ◽

Barbro Leijd

Keyword(s):

Ursodeoxycholic Acid ◽

Chenodeoxycholic Acid ◽

Acid Treatment ◽

Lithocholic Acid ◽

Serum Concentrations ◽

Biliary Cholesterol ◽

Serum Triglycerides ◽

Biliary Lipids ◽

Type Iv ◽

Daily Dose

1. In order to study the effects of chenodeoxycholic acid on serum and biliary lipids in hyperlipoproteinaemia, chenodeoxycholic acid was administered to seven type IIa, eight type IIb and eight type IV patients in a daily dose of 750 mg (1·9 mmol) for 3 months. 2. The serum concentrations of cholesterol and triglycerides were determined at 4-week intervals: cholesterol remained unchanged whereas triglycerides decreased 15–20%. 3. In 17 patients, biliary lipids were studied. The proportion of chenodeoxycholic acid in the bile increased to about 70%; lithocholic acid and ursodeoxycholic acid increased significantly. 4. Bile saturation with cholesterol decreased and correlated negatively with the proportion of chenodeoxycholic acid in biliary bile acids but positively with serum triglycerides. 5. It is concluded that chenodeoxycholic acid treatment in hyperlipoproteinaemia is associated with a parallel fall in serum triglycerides and biliary cholesterol and thus may prove to be a useful adjunct in hypolipidaemic treatment.

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