scholarly journals High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury

Hepatology ◽  
2013 ◽  
Vol 58 (1) ◽  
pp. 388-396 ◽  
Author(s):  
Minjun Chen ◽  
Jürgen Borlak ◽  
Weida Tong
Keyword(s):  
Liver Injury ◽  
Significant Risk ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Oral Medications ◽  
High Daily Dose ◽  
Daily Dose

High Daily Dose and Being a Substrate of Cytochrome P450 Enzymes Are Two Important Predictors of Drug-Induced Liver Injury

2014 ◽  
Vol 42 (4) ◽  
pp. 744-750 ◽  
Author(s):  
Ke Yu ◽  
Xingchao Geng ◽  
Minjun Chen ◽  
Jie Zhang ◽  
Bingshun Wang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Liver Injury ◽  
Cytochrome P450 Enzymes ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
High Daily Dose ◽  
Daily Dose

Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: Search for signals

Hepatology ◽  
2008 ◽  
Vol 47 (6) ◽  
pp. 2003-2009 ◽  
Author(s):  
Craig Lammert ◽  
Stefan Einarsson ◽  
Chandan Saha ◽  
Anna Niklasson ◽  
Einar Bjornsson ◽  
...  
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Oral Medications ◽  
Daily Dose

T1789 Oral Medications with Extensive Hepatic Metabolism May Have Higher Risk of Idiosyncratic Drug Induced Liver Injury (DILI)

2008 ◽  
Vol 134 (4) ◽  
pp. A-822
Author(s):  
Craig Lammert ◽  
Anna Niklasson ◽  
Einar Bjornsson ◽  
Naga P. Chalasani
Keyword(s):  
Liver Injury ◽  
Hepatic Metabolism ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Oral Medications

Independent cohort validation of hepatic metabolism, daily dose and comorbidities as features associated with delayed symptom onset in drug-induced liver injury

2018 ◽  
Vol 68 ◽  
pp. S602
Author(s):  
A. González-Jiménez ◽  
I. Medina-Caliz ◽  
M. Robles-Díaz ◽  
F. Bessone ◽  
N. Hernandez ◽  
...  
Keyword(s):  
Liver Injury ◽  
Symptom Onset ◽  
Hepatic Metabolism ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Daily Dose ◽  
Independent Cohort

Leberschaden unter oraler Antikoagulation, Statin- und ACE-Hemmertherapie

Praxis ◽  
2010 ◽  
Vol 99 (21) ◽  
pp. 1259-1265 ◽  
Author(s):  
Bruggisser ◽  
Terraciano ◽  
Rätz Bravo ◽  
Haschke
Keyword(s):  
Liver Injury ◽  
Wird Eine ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Ein 71-jähriger Patient stellt sich mit Epistaxis und ikterischen Skleren auf der Notfallstation vor. Der Patient steht unter einer Therapie mit Phenprocoumon, Atorvastatin und Perindopril. Anamnestisch besteht ein langjähriger Alkoholabusus. Laborchemisch werden massiv erhöhte Leberwerte (ALAT, Bilirubin) gesehen. Der INR ist unter oraler Antikoagulation und bei akuter Leberinsuffizienz >12. Die weiterführenden Abklärungen schliessen eine Virushepatitis und eine Autoimmunhepatitis aus. Nachdem eine Leberbiopsie durchgeführt werden kann, wird eine medikamentös-toxische Hepatitis, ausgelöst durch die Komedikation von Atorvastatin, Phenprocoumon und Perindopril bei durch Alkohol bereits vorgeschädigter Leber diagnostiziert. Epidemiologie, Pathophysiologie und Klink der medikamentös induzierten Leberschäden (drug induced liver injury, DILI), speziell von Coumarinen, Statinen und ACE-Hemmern werden im Anschluss an den Fallbericht diskutiert.

Drug-induced liver injury network (DILIN)

Hepatology ◽  
2004 ◽  
Vol 40 (4) ◽  
pp. 773-773 ◽  
Author(s):  
Jay H. Hoofnagle
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Drug induced liver injury associated with Flupirtine in 6 cases

2011 ◽  
Vol 49 (08) ◽  
Author(s):  
C Agne ◽  
K Rifai ◽  
HH Kreipe ◽  
MP Manns ◽  
F Puls
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Prevalence of and risk factors for cART-associated drug-induced liver injury (DILI) in HIV/HBV-coinfected, HIV/HCV-coinfected, and HIV-monoinfected patients

2013 ◽  
Vol 51 (05) ◽  
Author(s):  
N Pfisterer ◽  
M Mandorfer ◽  
T Reiberger ◽  
BA Payer ◽  
M Peck-Radosavljevic
Keyword(s):  
Risk Factors ◽  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury

WISP1 modulates immune cell infiltration upon drug-induced liver injury (DILI)

2015 ◽  
Vol 53 (12) ◽  
Author(s):  
AB Widera ◽  
L Pütter ◽  
S Leserer ◽  
G Campos ◽  
K Rochlitz ◽  
...  
Keyword(s):  
Liver Injury ◽  
Immune Cell ◽  
Cell Infiltration ◽  
Immune Cell Infiltration ◽  
Drug Induced ◽  
Drug Induced Liver Injury
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