Acute on chronic liver failure from nonalcoholic fatty liver disease: a growing and aging cohort with rising mortality

Hepatology ◽  
2020 ◽  
Author(s):  
Vinay Sundaram ◽  
Rajiv Jalan ◽  
Parth Shah ◽  
Ashwani K. Singal ◽  
Arpan A Patel ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Failure ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Nonalcoholic Fatty Liver

scholarly journals Nonalcoholic Fatty Liver Disease: A New Frontier for Hepatology in Bangladesh and a Call for Action to Combat

2017 ◽  
Vol 35 (4) ◽  
pp. 184-191
Author(s):  
Shahinul Alam ◽  
M Motahar Hossain ◽  
Golam Azam ◽  
Golam Mustafa ◽  
Mahbubul Alam ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Chronic Liver Disease ◽  
Fatty Liver Disease ◽  
Chronic Liver ◽  
Diabetic Patients ◽  
Socioeconomic Condition ◽  
Mortality And Morbidity ◽  
Nonalcoholic Fatty Liver

Nonalcoholic Fatty Liver Disease (NAFLD) is the condition where fat accumulates in liver without significant ingestion of alcohol. NAFLD has become one of the most common liver conditions throughout the world. At the dawn of the history of NAFLD it was thought that NAFLD is disease of obese individual but lean patients are increasingly detected to have NAFLD. It seems that insulin resistance is central to the pathogenesis of NAFLD. In addition, oxidative stress and cytokines are important contributing factors, resulting in steatosis and progressive liver damage in genetically susceptible individuals. NAFLD varies considerably by ethnic group and Bangladeshi ethnicity is an independent risk factor for NAFLD. Prevalence of NAFLD in general population of Bangladesh is 4 - 18.4 %, which jumps up to 49.8% in diabetic patients. With the changes in socioeconomic condition and life style, aetiology of chronic liver disease is drifting from infectious to noninfectious diseases and the contribution of NAFLD is progressively increasing. Hepatitis B and hepatitis C have been the leading causes of mortality and morbidity from chronic liver disease in Bangladesh. But with increase in awareness and mass vaccination against HBV, prevalence of both the diseases has been decreasing in the country. The most alarming feature is that there is a high prevalence of NASH among the NAFLD patients. NAFLD is emerging as the largest contributor of chronic liver disease in Bangladesh. This warrants the attention of health policy makers and clinicians to explore this frontier and combat it from right now.J Bangladesh Coll Phys Surg 2017; 35(4): 184-191

Metabolic associated fatty liver disease and acute-on-chronic liver failure

2022 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jacqueline Córdova-Gallardo ◽  
Andrew P. Keaveny ◽  
Xingshun Qi ◽  
Nahum Méndez-Sánchez
Keyword(s):  
Liver Disease ◽  
Liver Failure ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Chronic Liver ◽  
Chronic Liver Failure

Effect of a novel potential probioticLactobacillus paracaseiJlus66 isolated from fermented milk on nonalcoholic fatty liver in rats

2017 ◽  
Vol 8 (12) ◽  
pp. 4539-4546 ◽  
Author(s):  
Haiqing Ye ◽  
Qian Li ◽  
Zhengzhe Zhang ◽  
Maocheng Sun ◽  
Changhui Zhao ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Chronic Liver Disease ◽  
Fatty Liver Disease ◽  
Fermented Milk ◽  
Chronic Liver ◽  
Nonalcoholic Fatty Liver

Nonalcoholic fatty liver disease (NAFLD) is the main cause of chronic liver disease worldwide.

scholarly journals Serum Markers of Iron Metabolism in Chronic Liver Diseases

2018 ◽  
Vol 6 (6) ◽  
pp. 1010-1016 ◽  
Author(s):  
Mariana Penkova Radicheva ◽  
Albena Nikolaeva Andonova ◽  
Hristina Tancheva Milcheva ◽  
Nadejda Gospodinova Ivanova ◽  
Silviya Georgieva Kyuchukova ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Disease ◽  
Hepatitis C ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Chronic Hepatitis C ◽  
Fatty Liver Disease ◽  
Serum Markers ◽  
Chronic Liver ◽  
Nonalcoholic Fatty Liver

BACKGROUND: Disorders in the metabolism of iron in the direction of iron overload are observed not only in primary hemochromatosis but also in some chronic liver diseases other aetiology. Elevation of serum iron, ferritin and transferrin saturation is reported in nonalcoholic fatty liver disease and alcohol, chronic hepatitis C and liver cirrhosis.AIM: Aim of the study was to evaluate and compare the frequency of the iron serum markers in patients with various chronic liver diseases.MATERIAL AND METHODS: The study included a total of 246 persons -186 patients with chronic liver disease without cirrhosis (-115 men, women -71; average age of 50.41 ± 12.85, from 23 to 77 years) and 60 healthy controls (-30 men, women -30, middle-aged 50.50 ± 11.31, from 29 to 83 years). Medical history, physical examination and demographic data including height, weight, laboratory and instrumental studies were performed.RESULTS: The highest incidence of elevated serum iron, transferrin saturation and ferritin and decreased serum hepcidin found in cases of alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD) and chronic hepatitis C (CHC).CONCLUSION: Finally, analysis of the changes in serum markers of iron metabolism shows that the difference between healthy and sick with liver disease is primarily due to changes in alcoholic and nonalcoholic fatty liver disease, particularly steatohepatitis, and chronic hepatitis C.

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