scholarly journals Fat‐associated Lymphoid Clusters as Expandable Niches for Ectopic Liver Development

Hepatology ◽  
2021 ◽  
Author(s):  
Bing Han ◽  
Maria Giovanna Francipane ◽  
Amin Cheikhi ◽  
Joycelyn Johnson ◽  
Fei Chen ◽  
...  
Keyword(s):  
Liver Development ◽  
Ectopic Liver

Ectopic liver within the umbilical cord in a very preterm infant from a multiple gestation

2011 ◽  
pp. 110428110516006
Author(s):  
Victor Javier Lara-Díaz ◽  
Raul Garza-Bulnes ◽  
Raul Garza-Garza ◽  
Manuel Durand
Keyword(s):  
Preterm Infant ◽  
Umbilical Cord ◽  
Multiple Gestation ◽  
Very Preterm ◽  
Very Preterm Infant ◽  
Ectopic Liver

The Mitochondrial Thioredoxin is Required for Liver Development in Zebrafish

2014 ◽  
Vol 14 (6) ◽  
pp. 772-782 ◽  
Author(s):  
J. Zhang ◽  
X. Cui ◽  
L. Wang ◽  
F. Liu ◽  
T. Jiang ◽  
...  
Keyword(s):  
Liver Development

scholarly journals Engineering the Vasculature of Stem-Cell-Derived Liver Organoids

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 966
Author(s):  
Xv Zhang ◽  
Liling Tang ◽  
Qian Yi
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Drug Screening ◽  
Disease Modeling ◽  
Liver Development ◽  
Embryonic Liver ◽  
Hepatic Cells ◽  
Hepatic Vessels ◽  
Liver Organoids ◽  
Application Prospects

The vasculature of stem-cell-derived liver organoids can be engineered using methods that recapitulate embryonic liver development. Hepatic organoids with a vascular network offer great application prospects for drug screening, disease modeling, and therapeutics. However, the application of stem cell-derived organoids is hindered by insufficient vascularization and maturation. Here, we review different theories about the origin of hepatic cells and the morphogenesis of hepatic vessels to provide potential approaches for organoid generation. We also review the main protocols for generating vascularized liver organoids from stem cells and consider their potential and limitations in the generation of vascularized liver organoids.

scholarly journals Alteration of serum amino acid profiles by dietary adenine supplementation inhibits fatty liver development in rats

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hiroki Nishi ◽  
Daisuke Yamanaka ◽  
Masato Masuda ◽  
Yuki Goda ◽  
Koichi Ito ◽  
...  
Keyword(s):  
Amino Acid ◽  
Fatty Liver ◽  
Causative Factor ◽  
Amino Acid Profile ◽  
Liver Development ◽  
Concentration Data ◽  
Amino Acid Profiles ◽  
Arginine Deficiency ◽  
Branched Chain ◽  
Tag Accumulation

AbstractStudies on animal models have demonstrated that feeding a low-arginine diet inhibits triacylglycerol (TAG) secretion from the liver, resulting in marked fatty liver development in rats. Here, we first showed that culturing hepatocytes in the medium mimicking the serum amino acid profile of low-arginine diet-fed rats induced TAG accumulation in the cells, indicating that the specific amino acid profile caused TAG accumulation in hepatocytes. Dietary adenine supplementation completely recovered hepatic TAG secretion and abolished hepatic TAG accumulation in rats. A comprehensive non-linear analysis revealed that inhibition of hepatic TAG accumulation by dietary adenine supplementation could be predicted using only serum amino acid concentration data. Comparison of serum amino acid concentrations indicated that histidine, methionine, and branched-chain amino acid (BCAA) concentrations were altered by adenine supplementation. Furthermore, when the serum amino acid profiles of low-arginine diet-fed rats were altered by modifying methionine or BCAA concentrations in their diets, their hepatic TAG accumulation was abolished. Altogether, these results suggest that an increase in methionine and BCAA levels in the serum in response to dietary arginine deficiency is a key causative factor for hepatic TAG accumulation, and dietary adenine supplementation could disrupt this phenomenon by altering serum amino acid profiles.

β-Catenin is temporally regulated during normal liver development☆

2004 ◽  
Vol 126 (4) ◽  
pp. 1134-1146 ◽  
Author(s):  
Amanda Micsenyi ◽  
Xinping Tan ◽  
Tamara Sneddon ◽  
Jian-Hua Luo ◽  
George K. Michalopoulos ◽  
...  
Keyword(s):  
Normal Liver ◽  
Liver Development

Matrix metalloproteinases in early human liver development

1999 ◽  
Vol 112 (4) ◽  
pp. 277-282 ◽  
Author(s):  
F. Quondamatteo ◽  
T. Knittel ◽  
M. Mehde ◽  
G. Ramadori ◽  
R. Herken
Keyword(s):  
Matrix Metalloproteinases ◽  
Human Liver ◽  
Liver Development ◽  
Early Human

914 Heparanase expression during normal liver development and liver regeneration following partial hepatectomy

Hepatology ◽  
2003 ◽  
Vol 38 ◽  
pp. 598-598
Author(s):  
O GOLDSHMIDT ◽  
R YEIKILIS ◽  
M PAIZI ◽  
I VLODAVSKY ◽  
G SPIRA
Keyword(s):  
Liver Regeneration ◽  
Partial Hepatectomy ◽  
Normal Liver ◽  
Liver Development
Sign in / Sign up

Export Citation Format

Share Document