scholarly journals Loss of bile salt export pump aggravates lipopolysaccharide‐induced liver injury in mice due to impaired hepatic endotoxin clearance

Hepatology ◽  
2021 ◽  
Author(s):  
Jelena Remetic ◽  
Ahmed Ghallab ◽  
Zaynab Hobloss ◽  
Lisa Brackhagen ◽  
Reham Hassan ◽  
...  
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Bile Salt Export Pump

scholarly journals Cholestatic Drug Induced Liver Injury: A Function of Bile Salt Export Pump Inhibition and Farnesoid X Receptor Antagonism

2018 ◽  
Vol 4 (3) ◽  
pp. 265-279 ◽  
Author(s):  
Jonathan P. Jackson ◽  
Kimberly M. Freeman ◽  
Robert L. St. Claire ◽  
Chris B. Black ◽  
Kenneth R. Brouwer
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Farnesoid X Receptor ◽  
Bile Salt Export Pump ◽  
Drug Induced ◽  
Receptor Antagonism ◽  
Drug Induced Liver Injury

scholarly journals Development of an Adverse Outcome Pathway From Drug-Mediated Bile Salt Export Pump Inhibition to Cholestatic Liver Injury

2013 ◽  
Vol 136 (1) ◽  
pp. 97-106 ◽  
Author(s):  
Mathieu Vinken ◽  
Brigitte Landesmann ◽  
Marina Goumenou ◽  
Stefanie Vinken ◽  
Imran Shah ◽  
...  
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Adverse Outcome ◽  
Adverse Outcome Pathway ◽  
Bile Salt Export Pump ◽  
Cholestatic Liver Injury

scholarly journals Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective

2018 ◽  
Vol 104 (5) ◽  
pp. 916-932 ◽  
Author(s):  
J. Gerry Kenna ◽  
Kunal S. Taskar ◽  
Christina Battista ◽  
David L. Bourdet ◽  
Kim L.R. Brouwer ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Liver Injury ◽  
Bile Salt ◽  
Injury Risk ◽  
Bile Salt Export Pump ◽  
Drug Discovery And Development

Role of chemical structures and the 1331T>C bile salt export pump polymorphism in idiosyncratic drug-induced liver injury

2013 ◽  
Vol 33 (9) ◽  
pp. 1378-1385 ◽  
Author(s):  
Eugenia Ulzurrun ◽  
Camilla Stephens ◽  
Esperanza Crespo ◽  
Francisco Ruiz-Cabello ◽  
Julia Ruiz-Nuñez ◽  
...  
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Bile Salt Export Pump ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Chemical Structures

scholarly journals Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development

2010 ◽  
Vol 118 (2) ◽  
pp. 485-500 ◽  
Author(s):  
Ryan E. Morgan ◽  
Michael Trauner ◽  
Carlo J. van Staden ◽  
Paul H. Lee ◽  
Bharath Ramachandran ◽  
...  
Keyword(s):  
Liver Injury ◽  
Drug Development ◽  
Bile Salt ◽  
Human Liver ◽  
Bile Salt Export Pump ◽  
Pump Function ◽  
Susceptibility Factor

Evaluation of the relationship between inhibition of the bile salt export pump in vitro and risk of drug-induced liver injury in man

Toxicology ◽  
2010 ◽  
Vol 278 (3) ◽  
pp. 356
Author(s):  
Sarah Dawson ◽  
Simone Stahl ◽  
Jane Barber ◽  
Claire Summers ◽  
Nikki Paul ◽  
...  
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Bile Salt Export Pump ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
The Relationship

scholarly journals Toward Predicting Drug-Induced Liver Injury: Parallel Computational Approaches to Identify Multidrug Resistance Protein 4 and Bile Salt Export Pump Inhibitors

2015 ◽  
Vol 43 (5) ◽  
pp. 725-734 ◽  
Author(s):  
Matthew A. Welch ◽  
Kathleen Köck ◽  
Thomas J. Urban ◽  
Kim L. R. Brouwer ◽  
Peter W. Swaan
Keyword(s):  
Multidrug Resistance ◽  
Liver Injury ◽  
Bile Salt ◽  
Multidrug Resistance Protein ◽  
Bile Salt Export Pump ◽  
Drug Induced ◽  
Computational Approaches ◽  
Drug Induced Liver Injury ◽  
Resistance Protein

scholarly journals Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

Hepatology ◽  
2014 ◽  
Vol 60 (3) ◽  
pp. 1015-1022 ◽  
Author(s):  
Michael D. Aleo ◽  
Yi Luo ◽  
Rachel Swiss ◽  
Paul D. Bonin ◽  
David M. Potter ◽  
...  
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Mitochondrial Function ◽  
Injury Severity ◽  
Bile Salt Export Pump ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Dual Inhibition
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