Evaluation of the relationship between inhibition of the bile salt export pump in vitro and risk of drug-induced liver injury in man

Toxicology ◽  
2010 ◽  
Vol 278 (3) ◽  
pp. 356
Author(s):  
Sarah Dawson ◽  
Simone Stahl ◽  
Jane Barber ◽  
Claire Summers ◽  
Nikki Paul ◽  
...  
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Bile Salt Export Pump ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
The Relationship

In Vitro Inhibition of the Bile Salt Export Pump Correlates with Risk of Cholestatic Drug-Induced Liver Injury in Humans

2011 ◽  
Vol 40 (1) ◽  
pp. 130-138 ◽  
Author(s):  
Sarah Dawson ◽  
Simone Stahl ◽  
Nikki Paul ◽  
Jane Barber ◽  
J. Gerald Kenna
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Bile Salt Export Pump ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
In Vitro Inhibition

scholarly journals Cholestatic Drug Induced Liver Injury: A Function of Bile Salt Export Pump Inhibition and Farnesoid X Receptor Antagonism

2018 ◽  
Vol 4 (3) ◽  
pp. 265-279 ◽  
Author(s):  
Jonathan P. Jackson ◽  
Kimberly M. Freeman ◽  
Robert L. St. Claire ◽  
Chris B. Black ◽  
Kenneth R. Brouwer
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Farnesoid X Receptor ◽  
Bile Salt Export Pump ◽  
Drug Induced ◽  
Receptor Antagonism ◽  
Drug Induced Liver Injury

Role of chemical structures and the 1331T>C bile salt export pump polymorphism in idiosyncratic drug-induced liver injury

2013 ◽  
Vol 33 (9) ◽  
pp. 1378-1385 ◽  
Author(s):  
Eugenia Ulzurrun ◽  
Camilla Stephens ◽  
Esperanza Crespo ◽  
Francisco Ruiz-Cabello ◽  
Julia Ruiz-Nuñez ◽  
...  
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Bile Salt Export Pump ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Chemical Structures

scholarly journals Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

Hepatology ◽  
2014 ◽  
Vol 60 (3) ◽  
pp. 1015-1022 ◽  
Author(s):  
Michael D. Aleo ◽  
Yi Luo ◽  
Rachel Swiss ◽  
Paul D. Bonin ◽  
David M. Potter ◽  
...  
Keyword(s):  
Liver Injury ◽  
Bile Salt ◽  
Mitochondrial Function ◽  
Injury Severity ◽  
Bile Salt Export Pump ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Dual Inhibition

Drug-induced liver injury classification model based on in vitro human transcriptomics and in vivo rat clinical chemistry data

2014 ◽  
Vol 2 (4) ◽  
pp. 63-70 ◽  
Author(s):  
Danyel Jennen ◽  
Jan Polman ◽  
Mark Bessem ◽  
Maarten Coonen ◽  
Joost van Delft ◽  
...  
Keyword(s):  
Liver Injury ◽  
Clinical Chemistry ◽  
Classification Model ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Chemistry Data ◽  
Model Based ◽  
Injury Classification
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