The rise and fall and rise again of ammonia as a therapeutic target in hepatic encephalopathy

Hepatology ◽  
2022 ◽  
Author(s):  
T.H Tranah ◽  
D.L Shawcross
Keyword(s):  
Hepatic Encephalopathy ◽  
Therapeutic Target

The neurosteroid system: an emerging therapeutic target for hepatic encephalopathy

2007 ◽  
Vol 22 (3-4) ◽  
pp. 291-308 ◽  
Author(s):  
Samir Ahboucha ◽  
Roger F. Butterworth
Keyword(s):  
Hepatic Encephalopathy ◽  
Therapeutic Target

p38 MAP kinase is a therapeutic target for hepatic encephalopathy in rats with portacaval shunts

Gut ◽  
2011 ◽  
Vol 60 (11) ◽  
pp. 1572-1579 ◽  
Author(s):  
A. Agusti ◽  
O. Cauli ◽  
R. Rodrigo ◽  
M. Llansola ◽  
V. Hernandez-Rabaza ◽  
...  
Keyword(s):  
Hepatic Encephalopathy ◽  
Map Kinase ◽  
Therapeutic Target ◽  
P38 Map Kinase

Memapsin 2, a drug target for Alzheimer's disease

2003 ◽  
Vol 70 ◽  
pp. 213-220 ◽  
Author(s):  
Gerald Koelsch ◽  
Robert T. Turner ◽  
Lin Hong ◽  
Arun K. Ghosh ◽  
Jordan Tang
Keyword(s):  
Crystal Structure ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transition State ◽  
Amyloid Precursor Protein ◽  
Therapeutic Target ◽  
Drug Target ◽  
Aspartic Protease ◽  
Precursor Protein ◽  
Memapsin 2

Mempasin 2, a ϐ-secretase, is the membrane-anchored aspartic protease that initiates the cleavage of amyloid precursor protein leading to the production of ϐ-amyloid and the onset of Alzheimer's disease. Thus memapsin 2 is a major therapeutic target for the development of inhibitor drugs for the disease. Many biochemical tools, such as the specificity and crystal structure, have been established and have led to the design of potent and relatively small transition-state inhibitors. Although developing a clinically viable mempasin 2 inhibitor remains challenging, progress to date renders hope that memapsin 2 inhibitors may ultimately be useful for therapeutic reduction of ϐ-amyloid.

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