Acute systemic MK-801 induced functional uncoupling between hippocampal areas CA3 and CA1 with distant effect in the retrosplenial cortex

Hippocampus ◽  
2016 ◽  
Vol 27 (2) ◽  
pp. 134-144 ◽  
Author(s):  
Helena Buchtová ◽  
Iveta Fajnerová ◽  
Aleš Stuchlík ◽  
Štěpán Kubík
1997 ◽  
Vol 17 (2) ◽  
pp. 168-174 ◽  
Author(s):  
Vesna Jevtović-Todorović ◽  
Charity O. Kirby ◽  
John W. Olney

In acute brain injury syndromes, the potent N-methyl-D-aspartate (NMDA) antagonist, MK-801, can prevent neuronal degeneration, and the general anesthetics, isoflurane and propofol, may also provide neuroprotective benefits. An obstacle to the use of NMDA antagonists for neuroprotective purposes is that they can cause a neurotoxic vacuole reaction in cerebrocortical neurons. This study demonstrates the ability of isoflurane and propofol to prevent the neurotoxic vacuole reaction induced by MK-801. Low sedative doses of inhaled isoflurane (1%) or intravenous (i.v.) propofol (7.5 mg/kg/h) were as effective as higher general anesthetic doses. Thus, in the clinical management of acute brain injury conditions such as stroke and brain trauma, administration of one of these anesthetic agents together with an NMDA antagonist may be an excellent formula for obtaining optimal neuroprotection while eliminating serious side effects.


2011 ◽  
Vol 36 (1) ◽  
pp. 131-133 ◽  
Author(s):  
Motohiro Shiotani ◽  
Kyoko Nakano ◽  
Emiko Yamauchi ◽  
Yoshiya Oda ◽  
Satoru Hosokawa ◽  
...  

1991 ◽  
Vol 30 (6) ◽  
pp. 801-809 ◽  
Author(s):  
Frank R. Sharp ◽  
Pat Jasper ◽  
John Hall ◽  
Linda Noble ◽  
Stephen M. Sagar

2001 ◽  
Vol 913 (2) ◽  
pp. 185-189 ◽  
Author(s):  
Vesna Jevtovic-Todorovic ◽  
David F Wozniak ◽  
Sarah Powell ◽  
John W Olney

1995 ◽  
Vol 696 (1-2) ◽  
pp. 194-204 ◽  
Author(s):  
Andrew S. Fix ◽  
David F. Wozniak ◽  
Lewis L. Truex ◽  
Melanie McEwen ◽  
J. Phillip Miller ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document