NMDA receptor activity bidirectionally controls active decay of long‐term spatial memory in the dorsal hippocampus

Hippocampus ◽  
2019 ◽  
Author(s):  
Paola Virginia Migues ◽  
Jacinda Wong ◽  
Jeongho Lyu ◽  
Oliver Hardt
Keyword(s):  
Nmda Receptor ◽  
Spatial Memory ◽  
Dorsal Hippocampus ◽  
Receptor Activity

scholarly journals Ethanol Induces Long-Term Facilitation of NR2B-NMDA Receptor Activity in the Dorsal Striatum: Implications for Alcohol Drinking Behavior

2007 ◽  
Vol 27 (13) ◽  
pp. 3593-3602 ◽  
Author(s):  
J. Wang ◽  
S. Carnicella ◽  
K. Phamluong ◽  
J. Jeanblanc ◽  
J. A. Ronesi ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Alcohol Drinking ◽  
Drinking Behavior ◽  
Dorsal Striatum ◽  
Receptor Activity ◽  
Long Term Facilitation

scholarly journals Long-Term Development of Selective Neuronal Loss and the Mechanism of Protection by 2-Amino-7-Phosphonoheptanoate in a Rat Model of Incomplete Forebrain Ischaemia

1988 ◽  
Vol 8 (1) ◽  
pp. 64-78 ◽  
Author(s):  
Jeanette H. Swan ◽  
Mary C. Evans ◽  
Brian S. Meldrum
Keyword(s):  
Nmda Receptor ◽  
Dorsal Hippocampus ◽  
Protective Action ◽  
Neuronal Loss ◽  
Cell Loss ◽  
Significant Protection ◽  
Local Cerebral Blood Flow ◽  
Systemic Injection ◽  
Excitatory Neurotransmission

Excitatory neurotransmission at the N-methyl-D-aspartate (NMDA) receptor is selectively blocked by 2-amino-7-phosphonoheptanoate acid (2-APH). Acute focal microinjection of 2-APH into the rat hippocampus partially protects against cytopathology developing in selectively vulnerable neurons after 30 min of ischaemia and 2 h of reperfusion. We show that this protective action of 2-APH does not involve alterations in local cerebral blood flow (CBF). Intermediate cytopathology and long-term neuronal survival has been assessed in rats receiving focal injections of (±) 2-APH. 20 μg in 1 μl, into one dorsal hippocampus prior to and 4 and 10 h after a 10-min period of forebrain ischaemia. Cytopathology assessed 4 or 24 h after ischaemia shows no difference between the buffer and 2-APH–injected hippocampi. Assessment after 7 days survival shows a significant protection against neuronal loss in the CA1 zone of the 2-APH–injected hippocampus compared with the contralateral, buffer-injected hippocampus. Systemic injection of D(-)2-APH (675 mg/kg i.v. at 0 h, 4 h, and 10 h) affords significant protection to CA1 hippocampal neurones (as assessed after 7 days). These results suggest that maintained blockade of neurotransmission at the NMDA receptor in the postischaemic period can protect against delayed cell loss. The mechanism may be through antagonism of the excitotoxic action of an endogenous neurotransmitter acting in the postischaemic period.

Dietary omega-3 deficiency reduces BDNF content and activation NMDA receptor and Fyn in dorsal hippocampus: Implications on persistence of long-term memory in rats

2013 ◽  
Vol 17 (4) ◽  
pp. 186-192 ◽  
Author(s):  
Simone Azevedo Bach ◽  
Letícia V. de Siqueira ◽  
Alexandre P. Müller ◽  
Jean P. Oses ◽  
Andreia Quatrim ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Dorsal Hippocampus ◽  
Long Term Memory ◽  
Omega 3 ◽  
Term Memory

scholarly journals Retrograde Amnesia for Spatial Memory Induced by NMDA Receptor-Mediated Long-Term Potentiation

2001 ◽  
Vol 21 (1) ◽  
pp. 356-362 ◽  
Author(s):  
Vegard Heimly Brun ◽  
Kristin Ytterbø ◽  
Richard G. M. Morris ◽  
May-Britt Moser ◽  
Edvard I. Moser
Keyword(s):  
Nmda Receptor ◽  
Spatial Memory ◽  
Retrograde Amnesia ◽  
Long Term Potentiation ◽  
Term Potentiation
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