Ethanol Induces Long-Term Facilitation of NR2B-NMDA Receptor Activity in the Dorsal Striatum: Implications for Alcohol Drinking Behavior

Risk factors and long-term consequences of COVID-19 infection are unclear but can be investigated with large-scale genomic data. To distinguish correlation from causation, we performed in-silico analyses of three COVID-19 outcomes (N > 1,000,000). We show genetic correlation and putative causality with depressive symptoms, metformin use (genetic causality proportion (gĉp) with severe respiratory COVID-19 = 0.576, p = 1.07 × 10−5 and hospitalized COVID-19 = 0.713, p = 0.003), and alcohol drinking status (gĉp with severe respiratory COVID-19 = 0.633, p = 7.04 × 10−5 and hospitalized COVID-19 = 0.848, p = 4.13 × 10−13). COVID-19 risk loci associated with several hematologic biomarkers. Comprehensive findings inform genetic contributions to COVID-19 epidemiology, molecular mechanisms, and risk factors and potential long-term health effects of severe response to infection.

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NMDA receptor activation is required for the manifestation and maintenance of ventilatory long‐term facilitation in awake rats

The FASEB Journal ◽

10.1096/fasebj.20.4.a371-b ◽

2006 ◽

Vol 20 (4) ◽

Author(s):

Liming Ling ◽

Michelle McGuire

Keyword(s):

Nmda Receptor ◽

Receptor Activation ◽

Long Term Facilitation ◽

Nmda Receptor Activation ◽

Awake Rats

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NMDA receptor activity bidirectionally controls active decay of long‐term spatial memory in the dorsal hippocampus

Hippocampus ◽

10.1002/hipo.23096 ◽

2019 ◽

Cited By ~ 1

Author(s):

Paola Virginia Migues ◽

Jacinda Wong ◽

Jeongho Lyu ◽

Oliver Hardt

Keyword(s):

Nmda Receptor ◽

Spatial Memory ◽

Dorsal Hippocampus ◽

Receptor Activity

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Exploratory extracellular vesicle-bound miRNA profiling to identify candidate biomarkers of chronic alcohol drinking in non-human primates

10.1101/2021.07.28.454223 ◽

2021 ◽

Author(s):

Sloan A. Lewis ◽

Brianna Doratt ◽

Suhas Sureshchandra ◽

Tianyu Pan ◽

Steven W. Gonzalez ◽

...

Keyword(s):

Alcohol Use ◽

Alcohol Drinking ◽

Drinking Behavior ◽

Heavy Drinking ◽

Organ Damage ◽

Extracellular Vesicle ◽

Complex Nature ◽

Mirna Candidate ◽

Susceptibility To Infection

Background: Long-term alcohol drinking is associated with numerous health complications including susceptibility to infection, cancer, and organ damage. However, due to the complex nature of human drinking behavior, it is challenging to determine whether alcohol use should be considered a risk factor during diagnosis and treatment. We lack reliable biomarkers of alcohol use that could be used to determine drinking behavior prior to signs of overt organ damage. Recently, extracellular vesicle-bound microRNA (EV-miRNA) have been discovered to be consistent biomarkers of conditions including cancer and liver disease. Methods: In this study, we profiled the plasma EV-miRNA content by miRNA-Seq from 80 non-human primates after 12 months of voluntary ethanol drinking. Results: We identified a list of up- and downregulated EV-miRNA candidate biomarkers of both heavy drinking as well as those positively correlated with ethanol dose. We further overexpressed these candidate miRNA in control primary peripheral immune cells to assess potential functional mechanisms of these EV-miRNA. We identified that overexpression of miR-155, miR-154, miR-34c, miR-450a, and miR-204 led to increased inflammatory TNFA; or IL-6 production in PBMC after stimulation. Conclusion: This exploratory study identified several EV-miRNA that could serve as biomarkers of long-term alcohol drinking as well as provided a mechanism for alcohol-induced peripheral inflammation.

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