Examining Trichloroisocyanuric Acid and Oxalyl Chloride in Complementary Approaches to Fluorination of Group 15 Heteroatoms

2020 ◽  
Author(s):  
Dustin Bornemann ◽  
Fabian Brüning ◽  
Niccolò Bartalucci ◽  
Lionel Wettstein ◽  
Cody Ross Pitts
Keyword(s):  
Oxalyl Chloride ◽  
Group 15 ◽  
Trichloroisocyanuric Acid

scholarly journals Lewis pairing and frustration of group 13/15 elements geometrically enforced by (ace)naphthalene, biphenylene and (thio)xanthene backbones

2021 ◽  
Author(s):  
Omar Sadek ◽  
Ghenwa Bouhadir ◽  
Didier Bourissou
Keyword(s):  
Mixed Group ◽  
Group 13 ◽  
Group 15

The synthesis, structure, and reactivity of mixed group 13/group 15 compounds (E13 = B, Al, Ga, In, Tl; E15 = N, P, Sb, Bi) featuring a rigid (ace)naphthalene, biphenylene or (thio)xanthene backbone are discussed in this review.

scholarly journals Biomechanical Evaluation of Tarsometatarsal Fusion Comparing Crossing Lag Screws and Lag Screw With Locking Plate

2021 ◽  
pp. 107110072110335
Author(s):  
Sarah Ettinger ◽  
Lisa-Christin Hemmersbach ◽  
Michael Schwarze ◽  
Christina Stukenborg-Colsman ◽  
Daiwei Yao ◽  
...  
Keyword(s):  
Locking Plate ◽  
Screw Fixation ◽  
Operative Procedure ◽  
Fixation Technique ◽  
Lag Screw ◽  
Group 15 ◽  
Fresh Frozen ◽  
Biomechanical Evaluation ◽  
The Stability ◽  
End Stage

Background: Tarsometatarsal (TMT) arthrodesis is a common operative procedure for end-stage arthritis of the TMT joints. To date, there is no consensus on the best fixation technique for TMT arthrodesis and which joints should be included. Methods: Thirty fresh-frozen feet were divided into one group (15 feet) in which TMT joints I-III were fused with a lag screw and locking plate and a second group (15 feet) in which TMT joints I-III were fused with 2 crossing lag screws. The arthrodesis was performed stepwise with evaluation of mobility between the metatarsal and cuneiform bones after every application or removal of a lag screw or locking plate. Results: Isolated lag-screw arthrodesis of the TMT I-III joints led to significantly increased stability in every joint ( P < .05). Additional application of a locking plate caused further stability in every TMT joint ( P < .05). An additional crossed lag screw did not significantly increase rigidity of the TMT II and III joints ( P > .05). An IM screw did not influence the stability of the fused TMT joints. For TMT III arthrodesis, lag-screw and locking plate constructs were superior to crossed lag-screw fixation ( P < .05). TMT I fusion does not support stability after TMT II and III arthrodesis. Conclusion: Each fixation technique provided sufficient stabilization of the TMT joints. Use of a lag screw plus locking plate might be superior to crossed screw fixation. An additional TMT I and/or III arthrodesis did not increase stability of an isolated TMT II arthrodesis. Clinical Relevance: We report the first biomechanical evaluation of TMT I-III arthrodesis. Our results may help surgeons to choose among osteosynthesis techniques and which joints to include in performing arthrodesis of TMT I-III joints.

N-Chlorinative Ring Contraction of 1,4-Dimethoxyphthalazines via a Bicyclization/Ring-Opening Mechanism

Synthesis ◽  
2020 ◽  
Author(s):  
Jeong Kyun Im ◽  
Ilju Jeong ◽  
Jun-Ho Choi ◽  
Won-jin Chung ◽  
ByeongDo Yang ◽  
...  
Keyword(s):  
Ring Opening ◽  
Reaction Conditions ◽  
Ring Contraction ◽  
Silyl Group ◽  
Favorskii Rearrangement ◽  
Mechanistic Analysis ◽  
Group A ◽  
Overall Efficiency ◽  
Trichloroisocyanuric Acid

AbstractAn unprecedented N-chlorinative ring contraction of 1,2-diazines was discovered and investigated with an electrophilic chlorinating reagent, trichloroisocyanuric acid (TCICA). Through optimization and mechanistic analysis, the assisting role of n-Bu4NCl as an exogenous nucleophile was identified, and the optimized reaction conditions were applied to a range of 1,4-dimethoxyphthalazine derivatives. Also, an improvement of overall efficiency was demonstrated by the use of a labile O-silyl group. A bicyclization/ring-opening mechanism, inspired by the Favorskii rearrangement, was proposed and supported by the DFT calculations. Furthermore, the efforts on scope expansion as well as the evaluation of other electrophilic promoters revealed that the newly developed ring contraction reactivity is a unique characteristic of 1,4-dimethoxyphthalazine scaffold and TCICA.

ChemInform Abstract: OXIDATION OF LONG-CHAIN AND RELATED ALCOHOLS TO CARBONYLS BY DIMETHYL SULFOXIDE ′ACTIVATED′ BY OXALYL CHLORIDE

1978 ◽  
Vol 9 (44) ◽  
Author(s):  
A. J. MANCUSO ◽  
S. L. HUANG ◽  
D. SWERN
Keyword(s):  
Dimethyl Sulfoxide ◽  
Oxalyl Chloride ◽  
Long Chain

Reactions of N-aryl nitrogen oxides. 2. Reaction of N-aryl nitrones with oxalyl chloride

1974 ◽  
Vol 39 (13) ◽  
pp. 1975-1976 ◽  
Author(s):  
Dennis Liotta ◽  
A. D. Baker ◽  
Norman L. Goldman ◽  
Robert Engel
Keyword(s):  
Nitrogen Oxides ◽  
Oxalyl Chloride

One-Pot Synthesis of 3-Hydroxymaleic Anhydrides by Cyclization of 1,1-Bis(trimethylsiloxy)ketene Acetals with Oxalyl Chloride.

ChemInform ◽  
2005 ◽  
Vol 36 (20) ◽  
Author(s):  
Ehsan Ullah ◽  
Peter Langer
Keyword(s):  
Oxalyl Chloride ◽  
One Pot ◽  
One Pot Synthesis ◽  
Ketene Acetals

Oxalyl Chloride and Hydrazide Based Energetic Polynitro Derivatives

2016 ◽  
Vol 2016 (19) ◽  
pp. 3086-3093 ◽  
Author(s):  
Thomas M. Klapötke ◽  
Burkhard Krumm ◽  
Regina Scharf
Keyword(s):  
Oxalyl Chloride
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