Enzymatic elimination of O6-ethylguanine from the DNA of ethylnitrosourea-exposed normal and malignant rat brain cells grown under cell cultureversus in vivo conditions

1988 ◽  
Vol 41 (5) ◽  
pp. 762-766 ◽  
Author(s):  
Nam-Ho Huh ◽  
Manfred F. Rajewsky
Keyword(s):  
Rat Brain ◽  
Brain Cells

scholarly journals Phenethylamines in brain and liver of rats with experimentally induced phenylketonuria-like characteristics

1973 ◽  
Vol 132 (1) ◽  
pp. 95-100 ◽  
Author(s):  
David J. Edwards ◽  
Karl Blau
Keyword(s):  
Monoamine Oxidase ◽  
Rat Brain ◽  
Phenylalanine Hydroxylase ◽  
Brain Regions ◽  
Subcellular Fractions ◽  
Brain Cells ◽  
Blood Phenylalanine ◽  
Low Concentrations ◽  
Experimentally Induced

1. Phenethylamines were extracted from brain and liver of rats with phenylketonuria-like characteristics produced in vivo by inhibition of phenylalanine hydroxylase (EC 1.14.3.1) with p-chlorophenylalanine, with or without phenylalanine administration. To protect amines against oxidation by monoamine oxidase, pargyline was also administered. 2. β-Phenethylamine was the major compound found in brain and liver. β-Phenethanolamine and octopamine were also present, in lesser amounts, and the concentrations of these three amines paralleled blood phenylalanine concentrations. By comparison, tissues from control animals had only very low concentrations of these amines. 3. Small amounts of normetadrenaline, m-tyramine and 3-methoxytyramine were also found. 4. The inhibitors used, p-chlorophenylalanine and pargyline, gave rise to p-chlorophenethylamine and benzylamine respectively, the first via decarboxylation, the second probably by breakdown during extraction. 5. Distribution of phenethylamines in different brain regions and in subcellular fractions of rat brain cells was also investigated. The content of phenethylamine was highest in the striatum. 6. These findings are discussed in the light of changes occurring in human patients with uncontrolled phenylketonuria.

Persistence of plasmid DNA and expression in rat brain cells in vivo

1992 ◽  
Vol 115 (3) ◽  
pp. 400-413 ◽  
Author(s):  
Shoushu Jiao ◽  
Gyula Acsadi ◽  
Agnes Jani ◽  
Philip L. Felgner ◽  
Jon A. Wolff
Keyword(s):  
Rat Brain ◽  
Plasmid Dna ◽  
Brain Cells

INTERACTIONS BETWEEN FETAL RAT BRAIN CELLS AND MATURE BRAIN TISSUE IN VIVO AND IN VITRO

1993 ◽  
Vol 52 (3) ◽  
pp. 295 ◽  
Author(s):  
Kirsten Marienhagen ◽  
Paal-Henning Pedersen ◽  
Sverre Mork ◽  
Rolf Bierkvig
Keyword(s):  
Rat Brain ◽  
Brain Tissue ◽  
Brain Cells ◽  
Mature Brain ◽  
Fetal Rat ◽  
Fetal Rat Brain

Interactions between fetal rat brain cells and mature brain tissue in vivo and in vitro

1994 ◽  
Vol 20 (2) ◽  
pp. 130-143 ◽  
Author(s):  
K. Marienhagen ◽  
P.-H. Pedersen ◽  
A. J. A. Terzis ◽  
O. D. Laerum ◽  
H. Arnold ◽  
...  
Keyword(s):  
Rat Brain ◽  
Brain Tissue ◽  
Brain Cells ◽  
Mature Brain ◽  
Fetal Rat ◽  
Fetal Rat Brain

DNA Damage in Rat Brain Cells after In Vivo Exposure to 2450 MHz Electromagnetic Radiation and Various Methods of Euthanasia

1998 ◽  
Vol 149 (6) ◽  
pp. 637 ◽  
Author(s):  
Robert S. Malyapa ◽  
Eric W. Ahern ◽  
Chen Bi ◽  
William L. Straube ◽  
Marie LaRegina ◽  
...  
Keyword(s):  
Dna Damage ◽  
Electromagnetic Radiation ◽  
Rat Brain ◽  
Brain Cells

In vitro and in vivo transplantation of fetal rat brain cells following incubation with various anatomic tracing substances

1989 ◽  
Vol 27 (2) ◽  
pp. 121-132 ◽  
Author(s):  
Luc Stoppinni ◽  
Gregory A. Helm ◽  
Janet L. Stringer ◽  
Eric W. Lothman ◽  
James P. Bennett
Keyword(s):  
Rat Brain ◽  
Brain Cells ◽  
Fetal Rat ◽  
Fetal Rat Brain

A Model System for Studies of Effects on Oligodendroglia Development

1987 ◽  
Vol 14 (3) ◽  
pp. 181-183
Author(s):  
I.K. Grundt
Keyword(s):  
Rat Brain ◽  
Model System ◽  
Brain Cells ◽  
Marker Enzyme ◽  
Toxic Exposure ◽  
Age Dependent

The effects of methylmercury (MeHg) and triethyllead (Et3Pb) were tested on the development of oligodendroglia cells (OG) in primary glia-rich cultures of rat brain cells. The marker enzyme 2'3’-cyclic nucelotide 3’-phosphodiesterase (CNP) was used as an index of OG development. The increase in CNP was followed during 1–4 weeks of exposure. MeHg at 2.5x107 and 10 8M, and Et3Pb at 2.5x10 7M, markedly inhibited the age-dependent increase in CNP shown in control cultures. CNP was highly stimulated by 2.5x10-8M Et3Pb. These observations are discussed in relation to results from experiments in vivo on CNP activities after toxic exposure.

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