New insights into the vancomycin‐induced nephrotoxicity using in vitro metabolomics combined with physiologically based pharmacokinetic modeling

Journal of Applied Toxicology ◽

10.1002/jat.3951 ◽

2020 ◽

Vol 40 (7) ◽

pp. 897-907

Author(s):

Haiyan Du ◽

Zheng Li ◽

Yi Yang ◽

Xiao Li ◽

Yongxiang Wei ◽

...

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro , Imaging and Physiologically Based Pharmacokinetic Modeling Approaches

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.1183 ◽

2018 ◽

Vol 104 (5) ◽

pp. 865-889 ◽

Author(s):

Yingying Guo ◽

Xiaoyan Chu ◽

Neil J. Parrott ◽

Kim L.R. Brouwer ◽

Vicky Hsu ◽

...

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Approaches ◽

Physiologically Based Pharmacokinetic ◽

Drug Concentrations ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Modeling of Benzene Metabolism in Mice Through Extrapolation from In Vitro to In Vivo

Journal of Toxicology and Environmental Health Part A ◽

10.1080/00984100150501178 ◽

2001 ◽

Vol 62 (6) ◽

pp. 439-465 ◽

Author(s):

Cammey E. Cole ◽

Hien T. Tran ◽

Paul M. Schlosser

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Blood Concentrations of 1,4-Dioxane in Humans after Oral Administration Extrapolated from In Vivo Rat Pharmacokinetics, In Vitro Human Metabolism, and Physiologically Based Pharmacokinetic Modeling

JOURNAL OF HEALTH SCIENCE ◽

10.1248/jhs.56.557 ◽

2010 ◽

Vol 56 (5) ◽

pp. 557-565 ◽

Author(s):

Ryohji Takano ◽

Norie Murayama ◽

Kana Horiuchi ◽

Masato Kitajima ◽

Fumiaki Shono ◽

...

Keyword(s):

Oral Administration ◽

Pharmacokinetic Modeling ◽

Human Metabolism ◽

Physiologically Based Pharmacokinetic Modeling ◽

Blood Concentrations ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Blood concentrations of acrylonitrile in humans after oral administration extrapolated from in vivo rat pharmacokinetics, in vitro human metabolism, and physiologically based pharmacokinetic modeling

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2010.06.008 ◽

2010 ◽

Vol 58 (2) ◽

pp. 252-258 ◽

Author(s):

Ryohji Takano ◽

Norie Murayama ◽

Kana Horiuchi ◽

Masato Kitajima ◽

Masatoshi Kumamoto ◽

...

Keyword(s):

Oral Administration ◽

Pharmacokinetic Modeling ◽

Human Metabolism ◽

Physiologically Based Pharmacokinetic Modeling ◽

Blood Concentrations ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene

Inhalation Toxicology ◽

10.1080/08958378.2020.1715513 ◽

2019 ◽

Vol 31 (13-14) ◽

pp. 468-483 ◽

Author(s):

Harvey J. Clewell ◽

Jerry L. Campbell ◽

Cynthia Van Landingham ◽

Allison Franzen ◽

Miyoung Yoon ◽

...

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Modeling ◽

In Vitro Metabolism ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Response to “letter concerning: Clewell (2019) incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene.” (UIHT-2020-0053)

Inhalation Toxicology ◽

10.1080/08958378.2020.1817199 ◽

2020 ◽

Vol 32 (9-10) ◽

pp. 369-371

Author(s):

H. J. Clewell ◽

J. L. Campbell ◽

C. Van Landingham ◽

A. Franzen ◽

M. Yoon ◽

...

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Modeling ◽

In Vitro Metabolism ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Integration of in vitro data from three dimensionally cultured HepaRG cells and physiologically based pharmacokinetic modeling for assessment of acetaminophen hepatotoxicity

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2020.104661 ◽

2020 ◽

Vol 114 ◽

pp. 104661

Author(s):

Chi Zhang ◽

Qiang Zhang ◽

Jin Li ◽

Lin Yu ◽

Fengxiang Li ◽

...

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Heparg Cells ◽

Physiologically Based ◽

Acetaminophen Hepatotoxicity ◽

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Investigating the Impact of Drug Crystallinity in Amorphous Tacrolimus Capsules on Pharmacokinetics and Bioequivalence Using Discriminatory In Vitro Dissolution Testing and Physiologically Based Pharmacokinetic Modeling and Simulation

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2017.12.024 ◽

2018 ◽

Vol 107 (5) ◽

pp. 1330-1341 ◽

Author(s):

Hitesh S. Purohit ◽

Niraj S. Trasi ◽

Dajun D. Sun ◽

Edwin C.Y. Chow ◽

Hong Wen ◽

...

Keyword(s):

Modeling And Simulation ◽

Pharmacokinetic Modeling ◽

In Vitro Dissolution ◽

Dissolution Testing ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Pharmacokinetic Modeling And Simulation

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The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine

Drug Metabolism and Disposition ◽

10.1124/dmd.116.071639 ◽

2016 ◽

Vol 44 (10) ◽

pp. 1569-1578 ◽

Author(s):

H. Q. Nguyen ◽

E. Callegari ◽

R. S. Obach

Keyword(s):

Pharmacokinetic Modeling ◽

Poor Metabolizers ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Drug Metabolite ◽

Physiologically Based ◽

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CYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic Modeling

Drug Metabolism and Disposition ◽

10.1124/dmd.113.051755 ◽

2013 ◽

Vol 41 (12) ◽

pp. 2004-2011 ◽

Author(s):

Cong Xu ◽

Sara K. Quinney ◽

Yingying Guo ◽

Stephen D. Hall ◽

Lang Li ◽

...

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

In Vivo Extrapolation

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