Integration of in vitro data from three dimensionally cultured HepaRG cells and physiologically based pharmacokinetic modeling for assessment of acetaminophen hepatotoxicity

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2020.104661 ◽

2020 ◽

Vol 114 ◽

pp. 104661

Author(s):

Chi Zhang ◽

Qiang Zhang ◽

Jin Li ◽

Lin Yu ◽

Fengxiang Li ◽

...

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Heparg Cells ◽

Physiologically Based ◽

Acetaminophen Hepatotoxicity ◽

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The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine

Drug Metabolism and Disposition ◽

10.1124/dmd.116.071639 ◽

2016 ◽

Vol 44 (10) ◽

pp. 1569-1578 ◽

Author(s):

H. Q. Nguyen ◽

E. Callegari ◽

R. S. Obach

Keyword(s):

Pharmacokinetic Modeling ◽

Poor Metabolizers ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Drug Metabolite ◽

Physiologically Based ◽

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Estimation of Circulating Drug Metabolite Exposure in Human Using In Vitro Data and Physiologically Based Pharmacokinetic Modeling: Example of a High Metabolite/Parent Drug Ratio

Drug Metabolism and Disposition ◽

10.1124/dmd.117.078279 ◽

2017 ◽

Vol 46 (2) ◽

pp. 89-99 ◽

Author(s):

R. Scott Obach ◽

Jian Lin ◽

Emi Kimoto ◽

Sridhar Duvvuri ◽

Timothy Nicholas ◽

...

Keyword(s):

Parent Drug ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Drug Metabolite ◽

Physiologically Based ◽

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Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro , Imaging and Physiologically Based Pharmacokinetic Modeling Approaches

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.1183 ◽

2018 ◽

Vol 104 (5) ◽

pp. 865-889 ◽

Author(s):

Yingying Guo ◽

Xiaoyan Chu ◽

Neil J. Parrott ◽

Kim L.R. Brouwer ◽

Vicky Hsu ◽

...

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Approaches ◽

Physiologically Based Pharmacokinetic ◽

Drug Concentrations ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Modeling of Benzene Metabolism in Mice Through Extrapolation from In Vitro to In Vivo

Journal of Toxicology and Environmental Health Part A ◽

10.1080/00984100150501178 ◽

2001 ◽

Vol 62 (6) ◽

pp. 439-465 ◽

Author(s):

Cammey E. Cole ◽

Hien T. Tran ◽

Paul M. Schlosser

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Evaluation of Age-Related Pyrethroid Pharmacokinetic Differences in Rats: Physiologically-Based Pharmacokinetic Model Development Using In Vitro Data and In Vitro to In Vivo Extrapolation

Toxicological Sciences ◽

10.1093/toxsci/kfz042 ◽

2019 ◽

Vol 169 (2) ◽

pp. 365-379 ◽

Author(s):

Gina Song ◽

Marjory Moreau ◽

Alina Efremenko ◽

Brian G Lake ◽

Huali Wu ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Model Development ◽

Physiologically Based Pharmacokinetic ◽

Age Related ◽

Physiologically Based ◽

In Vivo Extrapolation ◽

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Blood Concentrations of 1,4-Dioxane in Humans after Oral Administration Extrapolated from In Vivo Rat Pharmacokinetics, In Vitro Human Metabolism, and Physiologically Based Pharmacokinetic Modeling

JOURNAL OF HEALTH SCIENCE ◽

10.1248/jhs.56.557 ◽

2010 ◽

Vol 56 (5) ◽

pp. 557-565 ◽

Author(s):

Ryohji Takano ◽

Norie Murayama ◽

Kana Horiuchi ◽

Masato Kitajima ◽

Fumiaki Shono ◽

...

Keyword(s):

Oral Administration ◽

Pharmacokinetic Modeling ◽

Human Metabolism ◽

Physiologically Based Pharmacokinetic Modeling ◽

Blood Concentrations ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Blood concentrations of acrylonitrile in humans after oral administration extrapolated from in vivo rat pharmacokinetics, in vitro human metabolism, and physiologically based pharmacokinetic modeling

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2010.06.008 ◽

2010 ◽

Vol 58 (2) ◽

pp. 252-258 ◽

Author(s):

Ryohji Takano ◽

Norie Murayama ◽

Kana Horiuchi ◽

Masato Kitajima ◽

Masatoshi Kumamoto ◽

...

Keyword(s):

Oral Administration ◽

Pharmacokinetic Modeling ◽

Human Metabolism ◽

Physiologically Based Pharmacokinetic Modeling ◽

Blood Concentrations ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene

Inhalation Toxicology ◽

10.1080/08958378.2020.1715513 ◽

2019 ◽

Vol 31 (13-14) ◽

pp. 468-483 ◽

Author(s):

Harvey J. Clewell ◽

Jerry L. Campbell ◽

Cynthia Van Landingham ◽

Allison Franzen ◽

Miyoung Yoon ◽

...

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Modeling ◽

In Vitro Metabolism ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Response to “letter concerning: Clewell (2019) incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene.” (UIHT-2020-0053)

Inhalation Toxicology ◽

10.1080/08958378.2020.1817199 ◽

2020 ◽

Vol 32 (9-10) ◽

pp. 369-371

Author(s):

H. J. Clewell ◽

J. L. Campbell ◽

C. Van Landingham ◽

A. Franzen ◽

M. Yoon ◽

...

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Modeling ◽

In Vitro Metabolism ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Investigating the Impact of Drug Crystallinity in Amorphous Tacrolimus Capsules on Pharmacokinetics and Bioequivalence Using Discriminatory In Vitro Dissolution Testing and Physiologically Based Pharmacokinetic Modeling and Simulation

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2017.12.024 ◽

2018 ◽

Vol 107 (5) ◽

pp. 1330-1341 ◽

Author(s):

Hitesh S. Purohit ◽

Niraj S. Trasi ◽

Dajun D. Sun ◽

Edwin C.Y. Chow ◽

Hong Wen ◽

...

Keyword(s):

Modeling And Simulation ◽

Pharmacokinetic Modeling ◽

In Vitro Dissolution ◽

Dissolution Testing ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Pharmacokinetic Modeling And Simulation

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