Compositional, Structural, and Kinetic Aspects of Lipid Digestion and Bioavailability: In Vitro, In Vivo, and Modeling Approaches

Lipid digestion and bioavailability are usually investigated separately, using different approaches (in vitro, modeling, in vivo). However, a few inclusive studies show that their kinetics are closely linked. Lipid bioavailability kinetics is likely involved in the development and evolution of several diseases, so lipid digestion kinetics could be involved as well and can be modulated by food design or combination. To illustrate this possibility, the compositional and structural aspects of lipid digestion kinetics, as investigated using in vitro and modeling approaches, are presented first. Then, in vivo and mixed approaches enabling the study of both kinetics are reviewed and discussed. Finally, disparate modeling approaches are introduced, and a unifying modeling scheme is proposed, opening new perspectives for understanding the role and interactions of various factors (chemical, physical, and biological) involved in lipid metabolism. Expected final online publication date for the Annual Review of Food Science and Technology, Volume 13 is March 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Curiosity might not help after all: Predicted trajectories for need for cognition and anxiety and depression symptoms based on findings by Zainal and Newman (2022)

In a recent article, Zainal and Newman (2022) reported that need for cognition (NFC) predicted anxiety and depression symptoms (ADS) across 10 years in a large (N = 6750) sample of community-dwelling adults, and furthermore that a within-person decrease in NFC was associated with an increase in ADS. Here, we analyze the modeling approaches used in that paper, and show that the two different modeling strategies employed give contradictory results, suggesting that the results are influenced by statistical artifacts and should be interpreted with caution.

Multi-scale reactive extrusion modeling approaches to design polymer synthesis, modification and mechanical recycling

Reactive extrusion (REX) is an important processing and production technique with applications in the field of polymer synthesis, modification and recycling. A full REX design demands a multi-scale approach recognizing...