Blood Concentrations of 1,4-Dioxane in Humans after Oral Administration Extrapolated from In Vivo Rat Pharmacokinetics, In Vitro Human Metabolism, and Physiologically Based Pharmacokinetic Modeling

Human Metabolism ◽

Blood Concentrations ◽

Blood concentrations of acrylonitrile in humans after oral administration extrapolated from in vivo rat pharmacokinetics, in vitro human metabolism, and physiologically based pharmacokinetic modeling

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2010.06.008 ◽

2010 ◽

Vol 58 (2) ◽

pp. 252-258 ◽

Cited By ~ 22

Author(s):

Ryohji Takano ◽

Norie Murayama ◽

Kana Horiuchi ◽

Masato Kitajima ◽

Masatoshi Kumamoto ◽

...

Keyword(s):

Oral Administration ◽

Human Metabolism ◽

Blood Concentrations ◽

Physiologically Based Pharmacokinetic Modeling of Benzene Metabolism in Mice Through Extrapolation from In Vitro to In Vivo

Journal of Toxicology and Environmental Health Part A ◽

10.1080/00984100150501178 ◽

2001 ◽

Vol 62 (6) ◽

pp. 439-465 ◽

Cited By ~ 18

Author(s):

Cammey E. Cole ◽

Hien T. Tran ◽

Paul M. Schlosser

Keyword(s):

CYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic Modeling

Drug Metabolism and Disposition ◽

10.1124/dmd.113.051755 ◽

2013 ◽

Vol 41 (12) ◽

pp. 2004-2011 ◽

Cited By ~ 19

Author(s):

Cong Xu ◽

Sara K. Quinney ◽

Yingying Guo ◽

Stephen D. Hall ◽

Lang Li ◽

...

Keyword(s):

Physiologically Based ◽

In Vivo Extrapolation

Computational Predictions of Mycophenolic Acid Exposure after Oral Administration using a Joined In Vitro–In Vivo Extrapolation and Physiologically-Based Pharmacokinetic Modeling Approach in Caucasian and Chinese Healthy Volunteers and Patients With Varying Degree of Renal Impairment

Transplantation Journal ◽

10.1097/01.tp.0000520312.63960.a6 ◽

2017 ◽

Vol 101 ◽

pp. S13-S14 ◽

Cited By ~ 1

Author(s):

Rujuta Joshi ◽

Raman Venkataramanan ◽

Hari Varun Kalluri

Keyword(s):

Renal Impairment ◽

Oral Administration ◽

Mycophenolic Acid ◽

Physiologically Based ◽

In Vivo Extrapolation ◽

Computational Predictions

Addressing Early Life Sensitivity Using Physiologically Based Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation

Toxicological Research ◽

10.5487/tr.2016.32.1.015 ◽

2016 ◽

Vol 32 (1) ◽

pp. 15-20 ◽

Cited By ~ 11

Author(s):

Miyoung Yoon ◽

Harvey J. Clewell

Keyword(s):

Early Life ◽

Physiologically Based ◽

In Vivo Extrapolation

Probabilistic risk assessment of gold nanoparticles after intravenous administration by integrating in vitro and in vivo toxicity with physiologically based pharmacokinetic modeling

Nanotoxicology ◽

10.1080/17435390.2018.1459922 ◽

2018 ◽

Vol 12 (5) ◽

pp. 453-469 ◽

Cited By ~ 11

Author(s):

Yi-Hsien Cheng ◽

Jim E. Riviere ◽

Nancy A. Monteiro-Riviere ◽

Zhoumeng Lin

Keyword(s):

Risk Assessment ◽

Gold Nanoparticles ◽

Intravenous Administration ◽

In Vivo Toxicity ◽

Human Plasma Concentrations of Tolbutamide and Acetaminophen Extrapolated from in vivo Animal Pharmacokinetics Using in vitro Human Hepatic Clearances and Simple Physiologically Based Pharmacokinetic Modeling for Radio-labeled Microdose Clinical Studies

RADIOISOTOPES ◽

10.3769/radioisotopes.64.509 ◽

2015 ◽

Vol 64 (8) ◽

pp. 509-519 ◽

Cited By ~ 4

Author(s):

Hiroshi YAMAZAKI ◽

Eriko KUNIKANE ◽

Sayako NISHIYAMA ◽

Norie MURAYAMA ◽

Makiko SHIMIZU ◽

...

Keyword(s):

Human Plasma ◽

Clinical Studies ◽

Plasma Concentrations ◽

Physiologically Based ◽

Animal Pharmacokinetics

Predicting human exposure of active drug after oral prodrug administration, using a joined in vitro/in silico–in vivo extrapolation and physiologically-based pharmacokinetic modeling approach

Journal of Pharmacological and Toxicological Methods ◽

10.1016/j.vascn.2012.12.002 ◽

2013 ◽

Vol 67 (3) ◽

pp. 203-213 ◽

Cited By ~ 12

Author(s):

Jonas Malmborg ◽

Bart A. Ploeger

Keyword(s):

In Silico ◽

Human Exposure ◽

Active Drug ◽

Physiologically Based ◽

In Vivo Extrapolation ◽

Oral Prodrug

Comment on M.V. Evans and J.C. Caldwell: Evaluation of two different metabolic hypotheses for dichloromethane toxicity using physiologically based pharmacokinetic modeling of in vivo gas uptake data exposure in female B6C3F1 mice, Toxicol. Appl. Pharmacol., 244, 280–290, 2010

Toxicology and Applied Pharmacology ◽

10.1016/j.taap.2010.07.012 ◽

2010 ◽

Vol 248 (1) ◽

pp. 63-64 ◽

Cited By ~ 2

Author(s):

M.W. Anders ◽

Melvin E. Andersen ◽

Harvey J. Clewell III ◽

Michael L. Gargas ◽

F. Peter Guengerich ◽

...

Keyword(s):

Gas Uptake ◽

Physiologically Based ◽

B6c3f1 Mice ◽

Uptake Data

Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro , Imaging and Physiologically Based Pharmacokinetic Modeling Approaches

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.1183 ◽

2018 ◽

Vol 104 (5) ◽

pp. 865-889 ◽

Cited By ~ 42

Author(s):

Yingying Guo ◽

Xiaoyan Chu ◽

Neil J. Parrott ◽

Kim L.R. Brouwer ◽

Vicky Hsu ◽

...

Keyword(s):

Modeling Approaches ◽

Drug Concentrations ◽