Physiologically Based Pharmacokinetic Modeling of Benzene Metabolism in Mice Through Extrapolation from In Vitro to In Vivo

Journal of Toxicology and Environmental Health Part A ◽

10.1080/00984100150501178 ◽

2001 ◽

Vol 62 (6) ◽

pp. 439-465 ◽

Author(s):

Cammey E. Cole ◽

Hien T. Tran ◽

Paul M. Schlosser

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Blood Concentrations of 1,4-Dioxane in Humans after Oral Administration Extrapolated from In Vivo Rat Pharmacokinetics, In Vitro Human Metabolism, and Physiologically Based Pharmacokinetic Modeling

JOURNAL OF HEALTH SCIENCE ◽

10.1248/jhs.56.557 ◽

2010 ◽

Vol 56 (5) ◽

pp. 557-565 ◽

Author(s):

Ryohji Takano ◽

Norie Murayama ◽

Kana Horiuchi ◽

Masato Kitajima ◽

Fumiaki Shono ◽

...

Keyword(s):

Oral Administration ◽

Pharmacokinetic Modeling ◽

Human Metabolism ◽

Physiologically Based Pharmacokinetic Modeling ◽

Blood Concentrations ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Blood concentrations of acrylonitrile in humans after oral administration extrapolated from in vivo rat pharmacokinetics, in vitro human metabolism, and physiologically based pharmacokinetic modeling

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2010.06.008 ◽

2010 ◽

Vol 58 (2) ◽

pp. 252-258 ◽

Author(s):

Ryohji Takano ◽

Norie Murayama ◽

Kana Horiuchi ◽

Masato Kitajima ◽

Masatoshi Kumamoto ◽

...

Keyword(s):

Oral Administration ◽

Pharmacokinetic Modeling ◽

Human Metabolism ◽

Physiologically Based Pharmacokinetic Modeling ◽

Blood Concentrations ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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CYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic Modeling

Drug Metabolism and Disposition ◽

10.1124/dmd.113.051755 ◽

2013 ◽

Vol 41 (12) ◽

pp. 2004-2011 ◽

Author(s):

Cong Xu ◽

Sara K. Quinney ◽

Yingying Guo ◽

Stephen D. Hall ◽

Lang Li ◽

...

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

In Vivo Extrapolation

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Addressing Early Life Sensitivity Using Physiologically Based Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation

Toxicological Research ◽

10.5487/tr.2016.32.1.015 ◽

2016 ◽

Vol 32 (1) ◽

pp. 15-20 ◽

Author(s):

Miyoung Yoon ◽

Harvey J. Clewell

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

In Vivo Extrapolation

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Probabilistic risk assessment of gold nanoparticles after intravenous administration by integrating in vitro and in vivo toxicity with physiologically based pharmacokinetic modeling

Nanotoxicology ◽

10.1080/17435390.2018.1459922 ◽

2018 ◽

Vol 12 (5) ◽

pp. 453-469 ◽

Author(s):

Yi-Hsien Cheng ◽

Jim E. Riviere ◽

Nancy A. Monteiro-Riviere ◽

Zhoumeng Lin

Keyword(s):

Risk Assessment ◽

Gold Nanoparticles ◽

Intravenous Administration ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

In Vivo Toxicity ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Human Plasma Concentrations of Tolbutamide and Acetaminophen Extrapolated from in vivo Animal Pharmacokinetics Using in vitro Human Hepatic Clearances and Simple Physiologically Based Pharmacokinetic Modeling for Radio-labeled Microdose Clinical Studies

RADIOISOTOPES ◽

10.3769/radioisotopes.64.509 ◽

2015 ◽

Vol 64 (8) ◽

pp. 509-519 ◽

Author(s):

Hiroshi YAMAZAKI ◽

Eriko KUNIKANE ◽

Sayako NISHIYAMA ◽

Norie MURAYAMA ◽

Makiko SHIMIZU ◽

...

Keyword(s):

Human Plasma ◽

Clinical Studies ◽

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Animal Pharmacokinetics

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Predicting human exposure of active drug after oral prodrug administration, using a joined in vitro/in silico–in vivo extrapolation and physiologically-based pharmacokinetic modeling approach

Journal of Pharmacological and Toxicological Methods ◽

10.1016/j.vascn.2012.12.002 ◽

2013 ◽

Vol 67 (3) ◽

pp. 203-213 ◽

Author(s):

Jonas Malmborg ◽

Bart A. Ploeger

Keyword(s):

In Silico ◽

Human Exposure ◽

Active Drug ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

In Vivo Extrapolation ◽

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Comment on M.V. Evans and J.C. Caldwell: Evaluation of two different metabolic hypotheses for dichloromethane toxicity using physiologically based pharmacokinetic modeling of in vivo gas uptake data exposure in female B6C3F1 mice, Toxicol. Appl. Pharmacol., 244, 280–290, 2010

Toxicology and Applied Pharmacology ◽

10.1016/j.taap.2010.07.012 ◽

2010 ◽

Vol 248 (1) ◽

pp. 63-64 ◽

Author(s):

M.W. Anders ◽

Melvin E. Andersen ◽

Harvey J. Clewell III ◽

Michael L. Gargas ◽

F. Peter Guengerich ◽

...

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

B6c3f1 Mice ◽

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Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro , Imaging and Physiologically Based Pharmacokinetic Modeling Approaches

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.1183 ◽

2018 ◽

Vol 104 (5) ◽

pp. 865-889 ◽

Author(s):

Yingying Guo ◽

Xiaoyan Chu ◽

Neil J. Parrott ◽

Kim L.R. Brouwer ◽

Vicky Hsu ◽

...

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Approaches ◽

Physiologically Based Pharmacokinetic ◽

Drug Concentrations ◽

Physiologically Based

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Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2013.01.008 ◽

2013 ◽

Vol 65 (3) ◽

pp. 316-324 ◽

Author(s):

Ai Tsukada ◽

Hiroshi Suemizu ◽

Norie Murayama ◽

Ryohji Takano ◽

Makiko Shimizu ◽

...

Keyword(s):

Plasma Concentrations ◽

Pharmacokinetic Modeling ◽

Chimeric Mice ◽

Physiologically Based Pharmacokinetic Modeling ◽

In Vivo Experiments ◽

Physiologically Based Pharmacokinetic ◽

Melengestrol Acetate ◽

Physiologically Based

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