Incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene

Inhalation Toxicology ◽

10.1080/08958378.2020.1715513 ◽

2019 ◽

Vol 31 (13-14) ◽

pp. 468-483 ◽

Author(s):

Harvey J. Clewell ◽

Jerry L. Campbell ◽

Cynthia Van Landingham ◽

Allison Franzen ◽

Miyoung Yoon ◽

...

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Modeling ◽

In Vitro Metabolism ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Response to “letter concerning: Clewell (2019) incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene.” (UIHT-2020-0053)

Inhalation Toxicology ◽

10.1080/08958378.2020.1817199 ◽

2020 ◽

Vol 32 (9-10) ◽

pp. 369-371

Author(s):

H. J. Clewell ◽

J. L. Campbell ◽

C. Van Landingham ◽

A. Franzen ◽

M. Yoon ◽

...

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Modeling ◽

In Vitro Metabolism ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Letter concerning: Clewell (2019) incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene

Inhalation Toxicology ◽

10.1080/08958378.2020.1806960 ◽

2020 ◽

Vol 32 (8) ◽

pp. 327-327

Author(s):

Marco Kaltofen ◽

Keeve E. Nachman ◽

Dale Hattis

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Modeling ◽

In Vitro Metabolism ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Probabilistic risk assessment of gold nanoparticles after intravenous administration by integrating in vitro and in vivo toxicity with physiologically based pharmacokinetic modeling

Nanotoxicology ◽

10.1080/17435390.2018.1459922 ◽

2018 ◽

Vol 12 (5) ◽

pp. 453-469 ◽

Author(s):

Yi-Hsien Cheng ◽

Jim E. Riviere ◽

Nancy A. Monteiro-Riviere ◽

Zhoumeng Lin

Keyword(s):

Risk Assessment ◽

Gold Nanoparticles ◽

Intravenous Administration ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

In Vivo Toxicity ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro , Imaging and Physiologically Based Pharmacokinetic Modeling Approaches

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.1183 ◽

2018 ◽

Vol 104 (5) ◽

pp. 865-889 ◽

Author(s):

Yingying Guo ◽

Xiaoyan Chu ◽

Neil J. Parrott ◽

Kim L.R. Brouwer ◽

Vicky Hsu ◽

...

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Approaches ◽

Physiologically Based Pharmacokinetic ◽

Drug Concentrations ◽

Physiologically Based

Download Full-text

Risk Assessment of Predicted Serum Concentrations of Bisphenol A in Children and Adults Following Treatment with Dental Composite Restoratives, Dental Sealants, or Orthodontic Adhesives using Physiologically Based Pharmacokinetic Modeling

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2020.104839 ◽

2020 ◽

pp. 104839

Author(s):

Bradford D. Bagley ◽

Jordan N. Smith ◽

Justin G. Teeguarden

Keyword(s):

Risk Assessment ◽

Bisphenol A ◽

Pharmacokinetic Modeling ◽

Dental Composite ◽

Serum Concentrations ◽

Physiologically Based Pharmacokinetic Modeling ◽

Orthodontic Adhesives ◽

Physiologically Based Pharmacokinetic ◽

Dental Sealants ◽

Physiologically Based

Download Full-text

081030 (M10, B20) A tricholoethylene risk assessment using a Monte Carlo analysis of parameter uncertainty in conjunction with physiologically-based pharmacokinetic modeling

Insurance Mathematics and Economics ◽

10.1016/0167-6687(96)81409-0 ◽

1996 ◽

Vol 18 (2) ◽

pp. 140

Keyword(s):

Risk Assessment ◽

Monte Carlo ◽

Parameter Uncertainty ◽

Monte Carlo Analysis ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Physiologically Based Pharmacokinetic Modeling of Benzene Metabolism in Mice Through Extrapolation from In Vitro to In Vivo

Journal of Toxicology and Environmental Health Part A ◽

10.1080/00984100150501178 ◽

2001 ◽

Vol 62 (6) ◽

pp. 439-465 ◽

Author(s):

Cammey E. Cole ◽

Hien T. Tran ◽

Paul M. Schlosser

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Examples of physiologically based pharmacokinetic modeling applied to risk assessment

Physiologically Based Pharmacokinetic (PBPK) Modeling ◽

10.1016/b978-0-12-818596-4.00011-4 ◽

2020 ◽

pp. 281-299

Author(s):

Lisa M. Sweeney ◽

Jeffery M. Gearhart

Keyword(s):

Risk Assessment ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Blood Concentrations of 1,4-Dioxane in Humans after Oral Administration Extrapolated from In Vivo Rat Pharmacokinetics, In Vitro Human Metabolism, and Physiologically Based Pharmacokinetic Modeling

JOURNAL OF HEALTH SCIENCE ◽

10.1248/jhs.56.557 ◽

2010 ◽

Vol 56 (5) ◽

pp. 557-565 ◽

Author(s):

Ryohji Takano ◽

Norie Murayama ◽

Kana Horiuchi ◽

Masato Kitajima ◽

Fumiaki Shono ◽

...

Keyword(s):

Oral Administration ◽

Pharmacokinetic Modeling ◽

Human Metabolism ◽

Physiologically Based Pharmacokinetic Modeling ◽

Blood Concentrations ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text

Blood concentrations of acrylonitrile in humans after oral administration extrapolated from in vivo rat pharmacokinetics, in vitro human metabolism, and physiologically based pharmacokinetic modeling

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2010.06.008 ◽

2010 ◽

Vol 58 (2) ◽

pp. 252-258 ◽

Author(s):

Ryohji Takano ◽

Norie Murayama ◽

Kana Horiuchi ◽

Masato Kitajima ◽

Masatoshi Kumamoto ◽

...

Keyword(s):

Oral Administration ◽

Pharmacokinetic Modeling ◽

Human Metabolism ◽

Physiologically Based Pharmacokinetic Modeling ◽

Blood Concentrations ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

Download Full-text