scholarly journals Elevated serum lactate dehydrogenase isoenzymes and aspartate transaminase distinguish Albers-Schönberg disease (Chloride Channel 7 Deficiency Osteopetrosis) among the sclerosing bone disorders

2010 ◽  
Vol 25 (11) ◽  
pp. 2515-2526 ◽  
Author(s):  
Michael P Whyte ◽  
Lydia G Kempa ◽  
William H McAlister ◽  
Fan Zhang ◽  
Steven Mumm ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Chloride Channel ◽  
Elevated Serum ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Aspartate Transaminase ◽  
Bone Disorders ◽  
Lactate Dehydrogenase Isoenzymes

Prognostic Significance of Elevated Serum Lactate Dehydrogenase (LDH) in Patients with Severe Sepsis

CHEST Journal ◽  
2004 ◽  
Vol 126 (4) ◽  
pp. 873S ◽  
Author(s):  
Joe G. Zein ◽  
Gregory L. Lee ◽  
Maroun Tawk ◽  
Mohammed Dabaja ◽  
Gary T. Kinasewitz
Keyword(s):  
Severe Sepsis ◽  
Lactate Dehydrogenase ◽  
Prognostic Significance ◽  
Elevated Serum ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase

scholarly journals Markedly Elevated Serum Lactate Dehydrogenase Levels Are a Clue to the Diagnosis of Disseminated Histoplasmosis in Patients with AIDS

1997 ◽  
Vol 24 (5) ◽  
pp. 942-944 ◽  
Author(s):  
G. R. Corcoran ◽  
H. Al-Abdely ◽  
C. D. Flanders ◽  
J. Geimer ◽  
T. F. Patterson
Keyword(s):  
Lactate Dehydrogenase ◽  
Elevated Serum ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Disseminated Histoplasmosis

Protective role of curcumin in myocardial oxidative damage induced by isoproterenol in rats

2007 ◽  
Vol 26 (12) ◽  
pp. 933-938 ◽  
Author(s):  
M Nazam Ansari ◽  
U Bhandari ◽  
KK Pillai
Keyword(s):  
Superoxide Dismutase ◽  
Creatine Kinase ◽  
Lactate Dehydrogenase ◽  
Myocardial Injury ◽  
Lipid Peroxides ◽  
Serum Lactate ◽  
Alanine Transaminase ◽  
Serum Lactate Dehydrogenase ◽  
Aspartate Transaminase ◽  
Endogenous Antioxidants

This study was designed to investigate the effect of oral curcumin pretreatment (200 mg/kg) on isoproterenol-induced myocardial injury in rats. Isoproterenol (85 mg/kg, s.c., in two divided doses at 24 h intervals) administration induced a statistically significant increase ( P < 0.01) in serum lactate dehydrogenase, creatine kinase, aspartate transaminase, and alanine transaminase activities and significant increase ( P < 0.01) in myocardial lipid peroxides levels as compared to vehicle control rats. Furthermore, significant depletion ( P < 0.01) of myocardial endogenous antioxidants viz. superoxide dismutase, catalase, and tissue glutathione levels were also found in the pathogenic control group, that is, isoproterenol only treated animals. Curcumin (200 mg/kg) pretreatment for 20 days in isoproterenol treated rats significantly lowered ( P < 0.01) the serum lactate dehydrogenase, creatine kinase, aspartate transaminase, alanine transaminase, and myocardial lipid peroxides levels and increased the levels of myocardial endogenous antioxidants (superoxide dismutase, catalase, and tissue glutathione) as compared to pathogenic control rats. Furthermore, histological examination of rat’s heart section confirmed myocardial injury with isoproterenol administration and near normal pattern with curcumin pretreatment. The results of our study provide clear evidence that the curcumin pretreatment enhances the antioxidant defense against isoproterenol-induced oxidative myocardial injury in rats and exhibit cardioprotective property.

Serum Lactate Dehydrogenase is Elevated in Ischemic Acute Tubular Necrosis but Not in Acute Rejection in Kidney Transplant Patients

2016 ◽  
Vol 27 (1) ◽  
pp. 53-57 ◽  
Author(s):  
Hefziba Green ◽  
Ana Tobar ◽  
Anat Gafter-Gvili ◽  
Leonard Leibovici ◽  
Tirza Klein ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Lactate Dehydrogenase ◽  
Acute Rejection ◽  
Acute Tubular Necrosis ◽  
Elevated Serum ◽  
Graft Function ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Antibody Mediated Rejection ◽  
Tubular Necrosis

Background: Serum lactate dehydrogenase (LDH) levels may help to distinguish ischemic acute tubular necrosis (ATN) from acute rejection after kidney transplantation. Methods: All kidney biopsies performed in the years 2010 to 2012 were reviewed. Serum LDH, creatinine level, clinical variables, and presence of donor-specific antibodies were recorded before the biopsy. Results: Overall 150 biopsies were included. Ischemic ATN was diagnosed in 45 biopsies and acute cellular-mediated rejection and/or antibody-mediated rejection in 59 biopsies, 38 of which were accompanied by ATN. Serum LDH was elevated in 23 (51%) of 45 cases with ischemic ATN versus 15 (14%) of 105 cases with other diagnoses ( P < .0001). Median serum LDH was 478 U/L (range 277-2018) for ischemic ATN and 372 U/L (range 191-748) for all other diagnoses ( P < .001). When delayed graft function or primary nonfunctioning grafts were caused by ischemic ATN, serum LDH was elevated in 58% of cases, but when caused by acute rejection, LDH was normal in 88% of cases ( P = .02). Conclusions: There is a strong association between elevated serum LDH 1 to 3 days before performing kidney biopsy and the diagnosis of ischemic ATN after kidney transplantation, especially at the immediate posttransplantation period. Normal serum LDH at this period should raise a suspicion of acute rejection.

scholarly journals Diagnostic Value of Serum Lactate Dehydrogenase Isoenzyme and Amino Acid Patterns in Several Schistosomal and Non-Schistosomal Disorders as Compared to other Biochemical Parameters

1996 ◽  
Vol 13 (1) ◽  
pp. 19-29 ◽  
Author(s):  
Samia A. Ahmed ◽  
Mohamed Z. Gad
Keyword(s):  
Bladder Cancer ◽  
Amino Acid ◽  
Lactate Dehydrogenase ◽  
Biochemical Parameters ◽  
Elevated Serum ◽  
Diagnostic Value ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Control Group ◽  
Ldh Isoenzyme

Serum lactate dehydrogenase (LDH) isoenzyme and amino acid (a. a) patterns were evaluated in comparison to several other biochemical parameters for liver and renal function with the objective of clarifying the differential diagnosis of hepatic disorders and predicting the outcome of schistosomal infection in Egyptian patients. Patients examined included those with complicated hepatic disorders and others with different stages of schistosomal infestation, hepatoma or bladder cancer, in addition to a normal control group. Several biochemical parameters appeared to be useful in establishing consistent differences or similarities between the studied groups. Examples are; elevated serum AST/ AL T ratio and methionine content in chronic schistosomiasis, elevated serum urea/creatinine ratio and leucine content in all schistosomal patients and extremely high levels of N-acetyl-β-D-glucosaminidase (NAG) in the urine of non-schistosomal bladder cancer patients. In addition, characteristic LDH isoenzyme profiles distinguish between the studied groups, in particular separating chronic schistosomiasis from schistosomal bladder cancer and hepatoma from other hepatic disorders.

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