Decreased Mechanical Strength and Collagen Content in SPARC-Null Periodontal Ligament Is Reversed by Inhibition of Transglutaminase Activity

The traditional Indian medicine—Ayurveda, describes various herbs, fats, oils and minerals with anti-aging as well as wound healing properties. With aging, numerous changes occur in skin, including decrease in tissue cell regeneration, decrease in collagen content, loss of skin elasticity and mechanical strength. We prepared five topical anti-aging formulations using cow ghee, flax seed oil,Phyllanthus emblicafruits,Shorea robustaresin,Yashada bhasmaas study materials. For preliminary efficacy evaluation of the anti-aging activity we chose excision and incision wound healing animal models and studied the parameters including wound contraction, collagen content and skin breaking strength which in turn is indicative of the tissue cell regeneration capacity, collagenation capacity and mechanical strength of skin. The group treated with the formulations containingYashada bhasmaalong withShorea robustaresin and flax seed oil showed significantly better wound contraction (P < .01), higher collagen content (P < .05) and better skin breaking strength (P < .01) as compared to control group; thus proposing them to be effective prospective anti-aging formulations.

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Effects of some lathyritic agents on the mechanical strength of the periodontal ligament of the rat mandibular first molar

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)56506-4 ◽

1989 ◽

Vol 49 ◽

pp. 223

Author(s):

Shigeo Ohshima ◽

Gen Nakamura ◽

Mototsugu Chiba

Keyword(s):

Mechanical Strength ◽

Periodontal Ligament ◽

Mandibular First Molar

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Biomechanical properties of the rectovaginal fascia. Is it really a fascia?

Urogynaecologia ◽

10.4081/uij.2011.e11 ◽

2011 ◽

Vol 25 (1) ◽

pp. 11

Author(s):

Karin Glavind ◽

Janus Bo Jespersen ◽

Mikkel Seyer-Hansen

Keyword(s):

Mechanical Properties ◽

Mechanical Strength ◽

Mechanical Testing ◽

Biomechanical Properties ◽

Abdominal Hysterectomy ◽

Collagen Content ◽

Significant Difference ◽

Testing And Measurement ◽

Abdominal Fascia

Background. The aim of this study was to find out whether the rectovaginal fascia was really a true fascia by comparing the mechanical properties and collagen content of the rectovaginal fascia in women operated for rectoceles to the abdominal fascia in patients having an abdominal hysterectomy. Materials and Methods. Thirty patients were included. During operation for rectocele or hysterectomy a biopsy measuring 8 x 15 mm was taken from the rectovaginal fascia or abdominal fascia. Mechanical testing and measurement of collagen content was performed. Results. A significant difference in mechanical strength of the tissue was found. If, however, the strength was corrected for collagen content there was no difference between the two groups. Conclusion. The quality of collagen was comparable in the two groups. This adds further evidence to the existence of a distinct rectovaginal fascia.

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