Response to Comments on “Diagnosis and Management of Osteoporosis of the Jaw: A Systematic Review and International Consensus”

IntroductionPrehabilitation in colorectal surgery is evolving and may minimise postoperative morbidity and mortality. With many different healthcare professionals contributing to the prehabilitation literature, there is significant variation in reported primary endpoints that restricts comparison. In addition, there has been limited work on patient-related outcome measures suggesting that patients with colorectal cancer needs and issues are being overlooked. The Defining Standards in Colorectal Optimisation Study aims to achieve international consensus from all stakeholders on key standards to provide a framework for reporting future prehabilitation research.Methods and analysisA systematic review will identify key standards reported in trials of prehabilitation in colorectal surgery. Standards that are important to patients will be identified by a patient and public involvement (PPI) event. The longlist of standards generated from the systematic review and PPI event will be used to develop a three-round online Delphi process. This will engage all stakeholders (healthcare professionals and patients) both nationally and internationally. The results of the Delphi will be followed by a face-to-face interactive consensus meeting that will define the final standards for prehabilitation for elective colorectal surgery.Ethics and disseminationThe University of Glasgow College of Medical, Veterinary and Life Sciences Ethics Committee has approved this protocol, which is registered as a study (200190120) with the Core Outcome Measures in Effectiveness Trials Initiative. Publication of the standards developed by all stakeholders will increase the potential for comparative research that advances understanding of the clinical application of prehabilitation.PROSPERO registration numberCRD42019120381.

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A Systematic Review of the Inclusion of Non-Inflammatory Ultrasonographic Enthesopathy Findings in Enthesitis Scoring Indices

Diagnostics ◽

10.3390/diagnostics11040669 ◽

2021 ◽

Vol 11 (4) ◽

pp. 669

Author(s):

Sheryl Mascarenhas ◽

Nina Couette

Keyword(s):

Systematic Review ◽

Inflammatory Disease ◽

Power Doppler ◽

Scoring Systems ◽

Doppler Signal ◽

Diagnosis And Management ◽

Inflammatory Conditions ◽

Rheumatic Conditions ◽

Cardinal Feature ◽

Power Doppler Signal

Ultrasound has advanced the diagnosis and management of patients with inflammatory rheumatic conditions. It can be used to identify and monitor enthesitis, a cardinal feature of spondyloarthropthies. Several enthesitis scoring systems utilizing ultrasound to determine entheseal involvement have been developed. These scoring systems generally rely on determining the presence or absence of erosions, tendon enlargement, power Doppler signal, or enthesophytes. This systematic review identified ultrasound scoring systems that have been utilized for evaluating enthesitis and what key components derive the score. Review of these scoring systems, however, demonstrated confounding as some of the score components including enthesophytes may be seen in non-inflammatory conditions and some components including erosions can be seen from chronic damage, but not necessarily indicate active inflammatory disease. What is furthermore limiting is that currently there is not an agreed upon term to describe non-inflammatory enthesopathies, further complicating these scoring systems. This review highlights the need for a more comprehensive ultrasound enthesopathy scoring index.

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First International Consensus on the diagnosis and management of fibromuscular dysplasia

Vascular Medicine ◽

10.1177/1358863x18821816 ◽

2019 ◽

Vol 24 (2) ◽

pp. 164-189 ◽

Cited By ~ 48

Author(s):

Heather L Gornik ◽

Alexandre Persu ◽

David Adlam ◽

Lucas S Aparicio ◽

Michel Azizi ◽

...

Keyword(s):

Fibromuscular Dysplasia ◽

Arterial Disease ◽

Future Research ◽

Consensus Protocol ◽

Vascular Medicine ◽

International Consensus ◽

Ongoing Research ◽

Diagnosis And Management ◽

The Us ◽

Future Research Directions

This article is a comprehensive document on the diagnosis and management of fibromuscular dysplasia (FMD), which was commissioned by the working group ‘Hypertension and the Kidney’ of the European Society of Hypertension (ESH) and the Society for Vascular Medicine (SVM). This document updates previous consensus documents/scientific statements on FMD published in 2014 with full harmonization of the position of European and US experts. In addition to practical consensus-based clinical recommendations, including a consensus protocol for catheter-based angiography and percutaneous angioplasty for renal FMD, the document also includes the first analysis of the European/International FMD Registry and provides updated data from the US Registry for FMD. Finally, it provides insights on ongoing research programs and proposes future research directions for understanding this multifaceted arterial disease.

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Diagnosis and management of congenital floor of mouth masses: A systematic review

International Journal of Pediatric Otorhinolaryngology ◽

10.1016/j.ijporl.2020.110541 ◽

2021 ◽

Vol 140 ◽

pp. 110541

Author(s):

Jordyn P. Lucas ◽

Meredith Allen ◽

Bianca Siegel ◽

Nathan Gonik

Keyword(s):

Systematic Review ◽

Diagnosis And Management ◽

Floor Of Mouth

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Systematic Review of the Role of Stereotactic Radiotherapy for Bone Metastases

JNCI Journal of the National Cancer Institute ◽

10.1093/jnci/djz101 ◽

2019 ◽

Vol 111 (10) ◽

pp. 1023-1032 ◽

Cited By ~ 8

Author(s):

Katie L Spencer ◽

Joanne M van der Velden ◽

Erin Wong ◽

Enrica Seravalli ◽

Arjun Sahgal ◽

...

Keyword(s):

Systematic Review ◽

Bone Metastases ◽

Local Control ◽

Stereotactic Radiotherapy ◽

Palliative Radiotherapy ◽

Included Study ◽

Pain Response ◽

Solid Organ ◽

International Consensus ◽

Conventional Radiotherapy

Abstract Background Stereotactic radiotherapy (SBRT) might improve pain and local control in patients with bone metastases compared to conventional radiotherapy, although an overall estimate of these outcomes is currently unknown. Methods A systematic review was carried out following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Pubmed, Embase, and Cochrane databases were systematically searched to identify studies reporting pain response and local control among patients with bone metastases from solid-organ tumors who underwent SBRT in 1–6 fractions. All studies prior to April 15, 2017, were included. Study quality was assessed by predefined criteria, and pain response and local control rates were extracted. Results A total of 2619 studies were screened; 57 were included (reporting outcomes for 3995 patients) of which 38 reported pain response and 45 local control rates. Local control rates were high with pain response rates above those previously reported for conventional radiotherapy. Marked heterogeneity in study populations and delivered treatments were identified such that quantitative synthesis was not appropriate. Reported toxicity was limited. Of the pain response studies, 73.7% used a retrospective cohort design and only 10.5% used the international consensus endpoint definitions of pain response. The median survival within the included studies ranged from 8 to 30.4 months, suggesting a high risk of selection bias in the included observational studies. Conclusions This review demonstrates the potential benefit of SBRT over conventional palliative radiotherapy in improving pain due to bone metastases. Given the methodological limitations of the published literature, however, large randomized trials are now urgently required to better quantify this benefit.

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