scholarly journals Genome-scale techniques highlight the epigenome and redefine fundamental principles of gene regulation

2011 ◽  
Vol 26 (6) ◽  
pp. 1155-1162 ◽  
Author(s):  
J Wesley Pike
Keyword(s):  
Gene Regulation ◽  
Genome Scale

scholarly journals Enhanced scale and scope of genome engineering and regulation using CRISPR/Cas in Saccharomyces cerevisiae

2019 ◽  
Vol 19 (7) ◽  
Author(s):  
Matthew Deaner ◽  
Hal S Alper
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Gene Regulation ◽  
Transcriptional Regulation ◽  
Gene Editing ◽  
Genome Engineering ◽  
Guide Rna ◽  
On Demand ◽  
Large Numbers ◽  
Genetic Modifications ◽  
Genome Scale

ABSTRACT Although only 6 years old, the CRISPR system has blossomed into a tool for rapid, on-demand genome engineering and gene regulation in Saccharomyces cerevisiae. In this minireview, we discuss fundamental CRISPR technologies, tools to improve the efficiency and capabilities of gene targeting, and cutting-edge techniques to explore gene editing and transcriptional regulation at genome scale using pooled approaches. The focus is on applications to metabolic engineering with topics including development of techniques to edit the genome in multiplex, tools to enable large numbers of genetic modifications using pooled single-guide RNA libraries and efforts to enable programmable transcriptional regulation using endonuclease-null Cas enzymes.

scholarly journals CressInt : A user-friendly web resource for genome-scale exploration of gene regulation in Arabidopsis thaliana

2015 ◽  
Vol 3-4 ◽  
pp. 48-55 ◽  
Author(s):  
Xiaoting Chen ◽  
Kevin Ernst ◽  
Frances Soman ◽  
Mike Borowczak ◽  
Matthew T. Weirauch
Keyword(s):  
Arabidopsis Thaliana ◽  
Gene Regulation ◽  
Web Resource ◽  
User Friendly ◽  
Genome Scale

scholarly journals Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics

2017 ◽  
Vol 6 (11) ◽  
pp. 732-746 ◽  
Author(s):  
Elaina M. Maldonado ◽  
Vytautas Leoncikas ◽  
Ciarán P. Fisher ◽  
J. Bernadette Moore ◽  
Nick J. Plant ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Metabolic Networks ◽  
Metabolic Enzymes ◽  
Physiologically Based Pharmacokinetics ◽  
Physiologically Based ◽  
Genome Scale

βARKct gene delivery reverses atrophic gene regulation and enhances β-adrenergic response in the unloaded heart

2012 ◽  
Vol 60 (S 01) ◽  
Author(s):  
H Brinks ◽  
S Longnus ◽  
T Carrel ◽  
J Rabinowitz ◽  
WJ Koch ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Gene Delivery ◽  
Adrenergic Response
Sign in / Sign up

Export Citation Format

Share Document