scholarly journals Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics

2017 ◽  
Vol 6 (11) ◽  
pp. 732-746 ◽  
Author(s):  
Elaina M. Maldonado ◽  
Vytautas Leoncikas ◽  
Ciarán P. Fisher ◽  
J. Bernadette Moore ◽  
Nick J. Plant ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Metabolic Networks ◽  
Metabolic Enzymes ◽  
Physiologically Based Pharmacokinetics ◽  
Physiologically Based ◽  
Genome Scale

scholarly journals Optimization of a modeling platform to predict oncogenes from genome‐scale metabolic networks of non‐small‐cell lung cancers

FEBS Open Bio ◽  
2021 ◽  
Author(s):  
You‐Tyun Wang ◽  
Min‐Ru Lin ◽  
Wei‐Chen Chen ◽  
Wu‐Hsiung Wu ◽  
Feng‐Sheng Wang
Keyword(s):  
Metabolic Networks ◽  
Small Cell ◽  
Small Cell Lung ◽  
Lung Cancers ◽  
Genome Scale

Systematic Investigation of Mouse Models of Parkinson’s Disease by Transcriptome Mapping on a Brain-Specific Genome-Scale Metabolic Network

2021 ◽  
Author(s):  
Ecehan Abdik ◽  
Tunahan Cakir
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Metabolic Network ◽  
Mouse Models ◽  
Mus Musculus ◽  
Metabolic Networks ◽  
Systematic Investigation ◽  
Omics Data ◽  
Metabolic Alterations ◽  
Genome Scale

Genome-scale metabolic networks enable systemic investigation of metabolic alterations caused by diseases by providing interpretation of omics data. Although Mus musculus (mouse) is one of the most commonly used model...

scholarly journals F2C2: a fast tool for the computation of flux coupling in genome-scale metabolic networks

2012 ◽  
Vol 13 (1) ◽  
Author(s):  
Abdelhalim Larhlimi ◽  
Laszlo David ◽  
Joachim Selbig ◽  
Alexander Bockmayr
Keyword(s):  
Metabolic Networks ◽  
Flux Coupling ◽  
Genome Scale

Physiologically based pharmacokinetics of digoxin in mdr1a knockout mice

1999 ◽  
Vol 88 (12) ◽  
pp. 1281-1287 ◽  
Author(s):  
Masami Kawahara ◽  
Atsushi Sakata ◽  
Toshiaki Miyashita ◽  
Ikumi Tamai ◽  
Akira Tsuji
Keyword(s):  
Knockout Mice ◽  
Physiologically Based Pharmacokinetics ◽  
Physiologically Based

scholarly journals Integration of metabolic databases for the reconstruction of genome-scale metabolic networks

2010 ◽  
Vol 4 (1) ◽  
pp. 114 ◽  
Author(s):  
Karin Radrich ◽  
Yoshimasa Tsuruoka ◽  
Paul Dobson ◽  
Albert Gevorgyan ◽  
Neil Swainston ◽  
...  
Keyword(s):  
Metabolic Networks ◽  
Genome Scale

Model-guided identification of novel gene amplification targets for improving succinate production in Escherichia coli NZN111

2017 ◽  
Vol 9 (10) ◽  
pp. 830-835 ◽  
Author(s):  
Xingxing Jian ◽  
Ningchuan Li ◽  
Qian Chen ◽  
Qiang Hua
Keyword(s):  
Escherichia Coli ◽  
Metabolic Engineering ◽  
Gene Amplification ◽  
Metabolic Networks ◽  
Computational Analysis ◽  
Succinate Production ◽  
Novel Gene ◽  
Metabolic Models ◽  
Genome Scale

Reconstruction and application of genome-scale metabolic models (GEMs) have facilitated metabolic engineering by providing a platform on which systematic computational analysis of metabolic networks can be performed.

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