βARKct gene delivery reverses atrophic gene regulation and enhances β-adrenergic response in the unloaded heart

2012 ◽  
Vol 60 (S 01) ◽  
Author(s):  
H Brinks ◽  
S Longnus ◽  
T Carrel ◽  
J Rabinowitz ◽  
WJ Koch ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Gene Delivery ◽  
Adrenergic Response

The Combination of Drug or Gene Delivery System Responding to Cellular Signals (D-RECS) and Sonoporation System for Effective and Safe Gene Delivery

2009 ◽  
Vol 1237 ◽  
Author(s):  
Akira Tsuchiya ◽  
Takeshi Mori ◽  
Yuki Naritomi ◽  
Jeong-Hun Kang ◽  
Daisuke Asai ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Regulation ◽  
Gene Delivery ◽  
Delivery System ◽  
Transfection Efficiency ◽  
Gene Transfection ◽  
Regulation System ◽  
Gene Delivery System

AbstractWe have developed new gene expression-regulating polymer that can activate transgene expression in response to target intracellular signals. Here, we tried applying sonoporation system to this gene regulation system to enhance the gene expression efficacy. Sonoporation is the method for effective gene transfection in vitro and in vivo. Therefore, the method might enhance the transfection efficiency in our polymer and realize an efficient and safe gene delivery system. Results suggested that the combination of our polymer and sonoporation could improve the gene expression compared to the system using only our polymer that transfers genes into cells via endocytosis. It also kept the ability of the gene regulation responding to cellular signals.

Intracellular Signal-Responsive Artificial Gene Regulation for Novel Gene Delivery

2002 ◽  
Vol 3 (5) ◽  
pp. 905-909 ◽  
Author(s):  
Yoshiki Katayama ◽  
Kenji Fujii ◽  
Etsuko Ito ◽  
Shigeki Sakakihara ◽  
Tatsuhiko Sonoda ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Gene Delivery ◽  
Novel Gene ◽  
Intracellular Signal ◽  
Artificial Gene

1004: In-Vivo Transfection of the Rat Corpus Cavernosum Using a Non-Viral, Linear Polyethylenimine Gene Delivery System: A Novel Application

2006 ◽  
Vol 175 (4S) ◽  
pp. 323-324 ◽  
Author(s):  
Joseph Dall'era ◽  
Sweaty Koul ◽  
Jesse Mills ◽  
Jeremy Myers ◽  
Randall B. Meacham ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Corpus Cavernosum ◽  
Gene Delivery System ◽  
System A ◽  
In Vivo Transfection ◽  
Linear Polyethylenimine
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