Autophagy‐lysosome dysfunction is involved in gastric ischemia‑reperfusion injury by promoting microglial activation in the paraventricular nucleus

2021 ◽  
Author(s):  
Aiqin Feng ◽  
Lin Gao ◽  
Peijian Yue ◽  
Yue Liu ◽  
Qiaoyu Zhou ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Paraventricular Nucleus ◽  
Microglial Activation ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Gastric Ischemia

Neuroregulative mechanism of hypothalamic paraventricular nucleus on gastric ischemia–reperfusion injury in rats

Life Sciences ◽  
2002 ◽  
Vol 71 (13) ◽  
pp. 1501-1510 ◽  
Author(s):  
Jian-fu Zhang ◽  
Yong-mei Zhang ◽  
Chang-dong Yan ◽  
Xiu-ping Zhou
Keyword(s):  
Reperfusion Injury ◽  
Paraventricular Nucleus ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Hypothalamic Paraventricular Nucleus ◽  
Gastric Ischemia

scholarly journals Terminalia catappa L. infusion accelerates the healing process of gastric ischemia-reperfusion injury in rats

2020 ◽  
Vol 256 ◽  
pp. 112793
Author(s):  
Rie Ohara ◽  
Larissa Lucena Périco ◽  
Vinicius Peixoto Rodrigues ◽  
Gabriela Bueno ◽  
Ana Caroline Zanatta ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Healing Process ◽  
Terminalia Catappa ◽  
Gastric Ischemia

scholarly journals Inhibition of the MEK/ERK pathway reduces microglial activation and interleukin-1-beta expression in spinal cord ischemia/reperfusion injury in rats

2007 ◽  
Vol 133 (4) ◽  
pp. 934-941 ◽  
Author(s):  
Kang Lu ◽  
Chung-Lung Cho ◽  
Cheng-Loong Liang ◽  
Shang-Der Chen ◽  
Po-Chou Liliang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Reperfusion Injury ◽  
Microglial Activation ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Interleukin 1 ◽  
Spinal Cord Ischemia ◽  
Erk Pathway ◽  
Interleukin 1 Beta

Angiotensin II in paraventricular nucleus contributes to sympathoexcitation in renal ischemia–reperfusion injury by AT1 receptor and oxidative stress

2015 ◽  
Vol 193 (1) ◽  
pp. 361-367 ◽  
Author(s):  
Behjat Seifi ◽  
Mehri Kadkhodaee ◽  
Enayatollah Bakhshi ◽  
Mina Ranjbaran ◽  
Maryam Zahmatkesh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Angiotensin Ii ◽  
Reperfusion Injury ◽  
Paraventricular Nucleus ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
At1 Receptor ◽  
Renal Ischemia ◽  
Renal Ischemia Reperfusion Injury ◽  
And Oxidative Stress

scholarly journals GABAA receptor overexpression in the lateral hypothalamic area attenuates gastric ischemia-reperfusion injury in rats

2014 ◽  
Vol 11 (2) ◽  
pp. 1057-1062 ◽  
Author(s):  
LIN GAO ◽  
TAO ZHU ◽  
GUILIN XIE ◽  
XIANGXIN LOU ◽  
SHIBAO LI ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Gabaa Receptor ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Lateral Hypothalamic Area ◽  
Hypothalamic Area ◽  
Lateral Hypothalamic ◽  
Gastric Ischemia

scholarly journals Effect of H2S on gastric ischemia-reperfusion injury in rats

2018 ◽  
Vol 26 (24) ◽  
pp. 1448-1454
Author(s):  
Jie Cui ◽  
Ji-He Zou ◽  
Lei Liu ◽  
Yue Shi ◽  
Wei-Li Qiao ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Gastric Ischemia

scholarly journals Argon reduces microglial activation and inflammatory cytokine expression in retinal ischemia/reperfusion injury

2021 ◽  
Vol 16 (1) ◽  
pp. 192
Author(s):  
Felix Ulbrich ◽  
Ulrich Goebel ◽  
Stefanie Scheid ◽  
Sashko Spassov ◽  
Nils Schallner ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Microglial Activation ◽  
Inflammatory Cytokine ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Retinal Ischemia ◽  
Cytokine Expression

Polymorphonuclear leukocyte infiltration into gastric mucosa after ischemia-reperfusion

1994 ◽  
Vol 266 (1) ◽  
pp. G48-G54 ◽  
Author(s):  
F. J. Andrews ◽  
C. Malcontenti-Wilson ◽  
P. E. O'Brien
Keyword(s):  
Gastric Mucosa ◽  
Reperfusion Injury ◽  
Polymorphonuclear Leukocytes ◽  
Ischemia Reperfusion Injury ◽  
Tissue Injury ◽  
Ischemia Reperfusion ◽  
Mucosal Injury ◽  
Immunoperoxidase Staining ◽  
Immunoperoxidase Technique ◽  
Gastric Ischemia

Polymorphonuclear leukocytes (PMN) have been implicated in the pathogenesis of ischemia-reperfusion injury. The objective of this study was to investigate PMN infiltration and distribution within the gastric mucosa of rats subjected to 30 min gastric ischemia followed by reperfusion. Sections of mucosa were stained for PMN using an immunoperoxidase technique, and injury was assessed by quantitative histology. In control animals, there were 4 +/- 2 PMN/mm2 in the superficial and 9 +/- 4 PMN/mm2 in the deep mucosa. This increased significantly to 67 +/- 9 PMN/mm2 (P < 0.05) and 160 +/- 53 PMN/mm2 (P < 0.01) respectively at 15 min of reperfusion. The percentage of these PMN which were extravasated was 83 +/- 4% in the superficial mucosa and 82 +/- 4% in the deep mucosa (P < 0.001 compared with control levels of 0% in superficial and 10% in deep mucosa). Significant PMN infiltration occurred before full expression of mucosal injury and treatment of rats with anti-PMN antisera blocked reperfusion injury (treated 10.7 +/- 1.4% mucosa damaged, controls 33.5 +/- 2.4%; P < 0.001). Treatment with allopurinol (100 mg/kg) significantly reduced the number of infiltrating PMN (superficial 7 +/- 1/mm2, deep 16 +/- 2/mm2; P < 0.01) and the percentage of extravasating PMN (superficial 40 +/- 10%, deep 30 +/- 15%; P < 0.01) while also significantly reducing tissue injury (21.9 +/- 1.9% mucosa damaged, P < 0.01 compared with controls). We conclude that the immunoperoxidase staining provides a simple means of identifying PMN in histological sections. Furthermore, our results support a role for PMN in gastric ischemia-reperfusion injury.

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