scholarly journals Physiologically Based Pharmacokinetics as a Component of Model‐Informed Drug Development: Where We Were, Where We Are, and Where We Are Heading

2020 ◽  
Vol 60 (S1) ◽  
Author(s):  
Amin Rostami‐Hodjegan ◽  
Stephen Toon
Keyword(s):  
Drug Development ◽  
Physiologically Based Pharmacokinetics ◽  
Physiologically Based

scholarly journals Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

2015 ◽  
Vol 7 (4) ◽  
pp. 383-391 ◽  
Author(s):  
Hasan Erbil Abaci ◽  
Michael L. Shuler
Keyword(s):  
Drug Development ◽  
Development Studies ◽  
Human Tissues ◽  
Design Strategies ◽  
Physiologically Based Pharmacokinetics ◽  
Microfluidic Platforms ◽  
Chip Design ◽  
Microphysiological Systems ◽  
Physiologically Based

Advances in maintaining multiple human tissues on microfluidic platforms has led to a growing interest in the development of microphysiological systems for drug development studies.

scholarly journals Physiologically Based Pharmacokinetics Is Impacting Drug Development and Regulatory Decision Making

2015 ◽  
Vol 4 (6) ◽  
pp. 313-315 ◽  
Author(s):  
M Rowland ◽  
LJ Lesko ◽  
A Rostami-Hodjegan
Keyword(s):  
Decision Making ◽  
Drug Development ◽  
Physiologically Based Pharmacokinetics ◽  
Regulatory Decision ◽  
Physiologically Based

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

2011 ◽  
Vol 51 (1) ◽  
pp. 45-73 ◽  
Author(s):  
Malcolm Rowland ◽  
Carl Peck ◽  
Geoffrey Tucker
Keyword(s):  
Drug Development ◽  
Regulatory Science ◽  
Physiologically Based Pharmacokinetics ◽  
Physiologically Based

Physiologically based pharmacokinetics of digoxin in mdr1a knockout mice

1999 ◽  
Vol 88 (12) ◽  
pp. 1281-1287 ◽  
Author(s):  
Masami Kawahara ◽  
Atsushi Sakata ◽  
Toshiaki Miyashita ◽  
Ikumi Tamai ◽  
Akira Tsuji
Keyword(s):  
Knockout Mice ◽  
Physiologically Based Pharmacokinetics ◽  
Physiologically Based

Design and Construction of Three-Dimensional Physiologically-Based Vascular Branching Networks for Respiratory Assist Devices

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Jose Santos ◽  
Alla A Gimbel ◽  
Athanasios Peppas ◽  
James G Truslow ◽  
Daniel Lang ◽  
...  
Keyword(s):  
Drug Development ◽  
Three Dimensional ◽  
Lab On A Chip ◽  
In Vitro Diagnostics ◽  
Assist Devices ◽  
Branching Networks ◽  
Physiologically Based ◽  
Vascular Branching ◽  
Design And Construction

Microfluidic lab-on-a-chip devices are changing the way that in vitro diagnostics and drug development are conducted, based on the increased precision, miniaturization and efficiency of these systems relative to prior...

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