Improving health in the military and beyond using salutogenic design

Purpose Service members of the US Department of Defense (DoD) have alarmingly high rates of depression, anxiety, probable stress disorders and suicidality, all of which are negative health conditions exacerbated by various external stressors. High-stress work conditions – to include shift work, hazardous territories, high-stakes mission sets and generally disconnected sites – require a work environment that facilitates, rather than inhibits, stress reduction and mental well-being. This paper aims to present “salutogenic design” as an innovative approach: Salutogenic design offers demonstrated architectural solutions that improve health and well-being. Design/methodology/approach This paper describes salutogenic design strategies beginning with the need for such an approach, the call to action to implement strategic and tactical solutions and the challenges and financial impacts of such a broad and innovative strategy to improve workplace health, well-being and performance in the DoD and beyond. Examples of these strategies, via biophilic design solutions, are presented in the central Table 1 as an easy-to-reference tool and supported by the voluminous literature as referenced, in part, through this research paper. Findings Salutogenic design strategies offer innovative, financially viable solutions to help mitigate stress and improve workforce well-being while maintaining the highest level of building security requirements in access-controlled spaces and disconnected sites, such as military installations and government compounds. Research limitations/implications Issues of mental and physical health are complex and multi-faceted, and they require complex and multi-faceted solutions. Salutogenic design is presented as one facet of that solution: a tangible solution to an often-intangible issue. Further, as a novel approach to address a critical DoD issue, Table 1 bridges the common gap between high-concept design theory and practical construction-application solutions, with positive value to the health, performance, quality-of-life and well-being of service members. Originality/value To the best of the author’s knowledge, this paper is the first to approach the DoD’s imperative to reduce service members’ mental stress with “salutogenic design.”

In Silico Discovery of Potential Azole-Containing mPGES-1 Inhibitors By Virtual Screening, Pharmacophore Modeling and Molecular Dynamics Simulations

Inhibition of microsomal prostaglandin E2 synthase-1 (mPGES-1) is promising for designing novel nonsteroidal anti-inflammatory drugs, as they lack side-effects associated with inhibition of cyclooxygenase enzymes. Azole compounds are nitrogen-containing heterocycles and have a wide use in medicine and are considered as promising compounds in medicinal chemistry. Various computer-aided drug design strategies are incorporated in this study. Structure-based virtual screening was performed employing various docking programs. Receiver Operator Characteristic (ROC) curves were used to evaluate the selectivity of each program. Furthermore, scoring power of Autodock4 and Autodock Vina was assessed by Pearson’s correlation coefficients. Pharmacophore models were generated and Güner-Henry score of the best model was calculated as 0.89. Binding modes of the final 10 azole compounds were analyzed and further investigation of the best binding (-8.38 kcal/mol) compound was performed using molecular dynamics simulation, revealing that furazan1224 (ZINC001142847306) occupied the binding site of the substrate, prostaglandin H2 (PGH2) and remained stable for 100 ns. Continuous hydrogen bonds with amino acids in the active site supported the stability of furazan1224 throughout the trajectory. Pharmacokinetic profile showed that furazan1224 lacks the risks of inhibiting cytochrome P450 3A4 enzyme and central nervous system-related side-effects.

The materialization of the Buen Vivir and the Rights of Nature: Rhetoric and Realities of Guayaquil Ecológico urban regeneration project

In 2008, Ecuador became the first country in the world to declare nature as a subject of rights based on the ‘Buen Vivir’ (Good Living) philosophy which is premised on an indigenous principle that envisions a world where humans are part-and-parcel of a larger natural and social environment. Although Ecuador’s constitution is groundbreaking from a legal standpoint, the question arises of how the rights of nature is spatially manifested beyond the designation of protected areas? To shed light on such interrogation, this article, based on qualitative research, focuses on the linear park component of the mega-project Guayaquil Ecológico heralded as a first materialization which champions the “Rights of Nature” under the vision of the Buen Vivir. It unravels the contested rhetoric and realities of the Guayaquil Ecológico linear park in a critical review of the as-built project in relation to the larger objectives of Buen Vivir. The Guayaquil Ecologico linear park promised to simultaneously upgrade both social and environmental dimensions. However, it did not fully address the complexity of Guayaquil’s socio-ecological context and some of the structural injustices of the estuarine territory. Buen Vivir was rhetorically mobilised to implement a project where aesthetic dimensions dominated, further perpetuating socio-ecological vulnerabilities through relocation and evictions. Furthermore, its implementation was dependent on a specific political moment, leaving it in a state of abandonment and neglect. The Buen Vivir philosophy—as a decolonial stance that challenges western forms of development—can offer a fundamental base to question current modes of territorial occupation based on extractivist planning and design strategies. It holds significant potential to serve as base to re-think the relationship between forms of settlement, natural dynamics, and worldviews.

The experiences, needs and barriers of people with impairments related to usability and accessibility of digital health solutions, levels of involvement in the design process and strategies for participatory and universal design: a scoping review

Objective Globally, the number of digital health solutions is increasing, but they are not always designed with access and utilisation for people with impairments in mind. Development efforts have often not included the voice and requirements of people with impairments, who make up 15% of the world’s population, despite the fact that this can help ensure broad access and utilisation. Little attention to and limited inclusion of people with impairments in the development of digital health solutions results in continued and reinforced inequalities in health services provision for people with impairments. This review investigates the needs and barriers of people with impairments related to use of digital health solutions and strategies to foster user participation, access and utilisation of digital health solutions. Methods This scoping review, based on the Joanna Briggs Institute Manual, had five phases: 1) identification of aim and research questions, 2) literature search in five databases (April/May 2020), 3) literature screening based on predetermined inclusion and exclusion criteria, 4) data extraction, and (5) reporting results. Results The literature search resulted in 5968 sources, of which 25 met our inclusion criteria. People with impairments appreciate digital health solutions that are designed to meet their specific impairment-related challenges. The reported needs and barriers related to technological design varied depending on the individuals’ challenges. The literature reported different types of participatory co-design strategies to foster access and utilisation of digital health solutions. Conclusion This scoping review support needs for increased awareness among developers to design solutions that meet people’s needs, contexts and states of health. By applying universal design as a strategy and including people with different types of impairments, starting in the idea creation phase of digital health solutions and throughout the development, developers can design solutions with better accessibility. Digital health solutions that are accessible and usable have a tremendous opportunity to foster health equity and achieve health promotion, prevention and self-care. This in turn can contribute to closing the gap between different population groups, reduce disparities and get the most from available healthcare services.

Design and Implementation of High Speed and Low Power 12-bit SAR ADC using 22nm FinFET

Successive Approximation Register (SAR) Analog to Digital Converter (ADC) architecture comprises of sub modules such as comparator, Digital to Analog Converter and SAR logic. Each of these modules imposes challenges as the signal makes transition from analog to digital and vice-versa. Design strategies for optimum design of circuits considering 22nm FinFET technology meeting area, timing, power requirements and ADC metrics is presented in this work. Operational Transconductance Amplifier (OTA) based comparator, 12-bit two stage segmented resistive string DAC architecture and low power SAR logic is designed and integrated to form the ADC architecture with maximum sampling rate of 1 GS/s. Circuit schematic is captured in Cadence environment with optimum geometrical parameters and performance metrics of the proposed ADC is evaluated in MATLAB environment. Differential Non Linearity and Integral Non Linearity metrics for the 12-bit ADC is limited to +1.15/-1 LSB and +1.22/-0.69 LSB respectively. ENOB of 10.1663 with SNR of 62.9613 dB is achieved for the designed ADC measured for conversion of input signal of 100 MHz with 20dB noise. ADC with sampling frequency upto 1 GSps is designed in this work with low power dissipation less than 10 mW.

Generalized Methodology Application for System Design

The design process for analogue circuit design is formulated on the basis of the optimum control theory. The artificially introduced special control vector is defined for the redistribution of computational costs between network analysis and parametric optimization. This redistribution minimizes computer time. The problem of the minimal-time network design can be formulated in this case as a classical problem of the optimal control for some functional minimization. There is a principal difference between the new approach and before elaborated methodology. This difference is based on a higher level of the problem generalization. In this case the structural basis of design strategies is more complete and this circumstance gives possibility to obtain a great value of computer time gain. Numerical results demonstrate the effectiveness and prospects of a more generalized approach to circuit optimization. This approach generalizes the design process and generates an infinite number of the different design strategies that will serve as the structural basis for the minimal time algorithm construction. This paper is advocated to electronic systems built with transistors. The main equations for the system design process were elaborated.

Passive Design Strategies for Energy Efficient Buildings in the Arabian Desert

This study aims to assess passive design features through the extensive modifications of building envelopes to affect the energy efficiency of residential buildings in hot arid climates. In support of the aim of this research, the annual electric energy bill of a typical residential building in Sharurah was collected and analyzed. Then, the DesignBuilder simulation program was used to investigate how different modifications of building envelopes could affect the energy consumption of the residential buildings under common scenarios. Varied thermal insulation, different types of glass, shading devices, and green roof were investigated with this perspective. The simulation results show that thermal insulation can significantly reduce annual energy consumption by as high as 23.6%, followed by green roofs. In contrast, shading devices and glazing system types were fewer superiors. The results also indicate that the effective combination of certain strategies can reduce total energy consumption by 35.4% relative to the base case (BC) of this research.

Industrial Buildings with Zero Energy Consumption: Cathedral Warehouse for Sherry Wines

The industrial sector needs solutions and strategies that allow buildings to reduce their energy consumption and develop their daily business activities. This paper discusses the long-term monitoring measures of indoor thermal conditions in a warehouse with zero energy consumption. The objective is to promote the use of passive design strategies within the industrial sector by analyzing an example of the feasibility of achieving controlled environmental conditions with zero energy consumption. In total, more than a million data points were processed and analyzed in different periods of the year. Experimental measurements showed strong gradients in the vertical distribution of temperature, this being a key aspect of the general behavior of the indoor environment of the warehouse. A standard comparison variable was developed to quantify the monthly and daily evolution of vertical stratification of the air to explain in detail the thermal behavior of the warehouse throughout the year. The results showed the efficacy of the design of these constructions to mitigate the high temperatures typical in a Mediterranean-Oceanic climate. This example of ingenuity in passive design demonstrates how, by combining the right strategies, the desired conditions can be obtained without any energy consumption.

Recent Developments of Coumarin-based Hybrids in Drug Discovery

Coumarin scaffold is a highly significant O-heterocycle, namely benzopyran-2-ones, form an elite class of naturally occurring compounds that possess promising therapeutic perspectives. Based on its broad spectrum of biological activities, the privileged coumarin scaffold is applied to medicinal and pharmacological treatments by several rational design strategies and approaches. Structure-activity relationships of the coumarin-based hybrids with various bioactivity fragments revealed significant information toward the further development of highly potent and selective disorder therapeutic agents. The molecular docking studies between coumarins and critical therapeutic enzymes demonstrated mode of action by forming noncovalent interactions with more than one receptor, further rationally confirm information about structure-activity relationships. This review summarizes recent developments relating to coumarin-based hybrids with other pharmacophores aiming to numerous feasible therapeutic enzymatic targets to combat various therapeutic fields, including anticancer, antimicrobic, anti-Alzheimer, anti-inflammatory activities.

Persistent Postural-Perceptual Dizziness Interventions—An Embodied Insight on the Use Virtual Reality for Technologists

Persistent and inconsistent unsteadiness with nonvertiginous dizziness (persistent postural-perceptual dizziness (PPPD)) could negatively impact quality of life. This study highlights that the use of virtual reality (VR) systems offers bimodal benefits to PPPD, such as understanding symptoms and providing a basis for treatment. The aim is to develop an understanding of PPPD and its interventions, including current trends of VR involvement to extrapolate and re-evaluate VR design strategies. Therefore, recent virtual-reality-based research work that progressed in understanding PPPD is identified, collected, and analysed. This study proposes a novel approach to the understanding of PPPD, specifically for VR technologists, and examines the principles of effectively aligning VR development for PPPD interventions.