Reactive extraction of 3-hydroxypropionic acid from model aqueous solutions and real bioconversion media. Comparison with its isomer 2-hydroxypropionic (lactic) acid

2015 ◽  
Vol 91 (8) ◽  
pp. 2276-2285 ◽  
Author(s):  
Marwen Moussa ◽  
Grégoire Burgé ◽  
Florian Chemarin ◽  
Rana Bounader ◽  
Claire Saulou-Bérion ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Aqueous Solutions ◽  
Reactive Extraction ◽  
Media Comparison ◽  
Hydroxypropionic Acid

Fermentation of Glucose to Lactic Acid Coupled with Reactive Extraction:  A Review

2004 ◽  
Vol 43 (19) ◽  
pp. 5969-5982 ◽  
Author(s):  
Kailas L. Wasewar ◽  
Archis A. Yawalkar ◽  
Jacob A. Moulijn ◽  
Vishwas G. Pangarkar
Keyword(s):  
Lactic Acid ◽  
Reactive Extraction

scholarly journals Reactive Extraction of Lactic Acid, Formic Acid and Acetic Acid from Aqueous Solutions with Tri-n-octylamine/1-Octanol/n-Undecane

2019 ◽  
Vol 3 (2) ◽  
pp. 43 ◽  
Author(s):  
Nuttakul Mungma ◽  
Marlene Kienberger ◽  
Matthäus Siebenhofer
Keyword(s):  
Mass Transfer ◽  
Acetic Acid ◽  
Lactic Acid ◽  
Formic Acid ◽  
Fermentation Broth ◽  
Lactic Acid Production ◽  
Mass Action ◽  
Reactive Extraction ◽  
Technical Application ◽  
Pka Value

The present work develops the basics for the isolation of lactic acid, acetic acid and formic acid from a single as well as a mixed feed stream, as is present, for example, in fermentation broth for lactic acid production. Modelling of the phase equilibria data is performed using the law of mass action and shows that the acids are extracted according to their pka value, where formic acid is preferably extracted in comparison to lactic and acetic acid. Back-extraction was performed by 1 M NaHCO3 solution and shows the same tendency regarding the pka value. Based on lactic acid, the solvent phase composition, consisting of tri-n-octylamine/1-octanol/n-undecane, was optimized in terms of the distribution coefficient. The data clearly indicate that, compared to physical extraction, mass transfer can be massively enhanced by reactive extraction. With increasing tri-n-octylamine and 1-octanol concentration, the equilibrium constant increases. However, even when mass transfer increases, tri-n-octylamine concentrations above 40 wt%, lead to third phase formation, which needs to be prevented for technical application. The presented data are the basis for the transfer to liquid membrane permeation, which enables the handling of emulsion tending systems.

scholarly journals The diffusion of oxygen and lactic acid through tissues

1928 ◽  
Vol 104 (728) ◽  
pp. 39-96 ◽  
Keyword(s):  
Lactic Acid ◽  
Aqueous Solutions ◽  
Nerve Fiber ◽  
Living Cell ◽  
Diffusion Constant ◽  
Fatigued Muscle ◽  
Single Nerve ◽  
Capillary Circulation ◽  
Determining Factor

The diffusion of dissolved substances through cells and tissues is a determining factor in many vital processes. The slowness of diffusion on the scale of ordinary sensible objects gives to the unaided imagination an imperfect realisation of its speed and importance in systems of the dimensions of the living cell. The diffusion constant k is expressed in terms of the number of unit quantities of substance which diffuse per minute across an area of 1 sq. cm. in a gradient of concentration per cm. of 1 unit quantity per c. c. For aqueous solutions of ordinary substances k is usually of the order of 2 to 10 times 10 -4 . The diffusion constant is of the dimensions L 2 T -1 , 2 in length, -1 in time. Expressing it in units of 1μ (0·0001 cm.) instead of 1 cm., and of 1σ (0·001 sec.) instead of minutes, k is of the order of unity, instead of multiple of 10 -4 . Thus the diffusion constant is a fairly large quantity for systems involving distances of the order of 1μ and times of the order of 1σ. A cylinder 1 cm. in diameter composed of material similar to frog's nerve, if suddenly placed in oxygen, would take 185 minutes to attain 90 per cent. of is full saturation with that gas. An actual nerve 0·7 mm. thick would take 54 seconds for the same stage of saturation to be reached. A single nerve fiber 7μ thick would take only 5·4 σ. Again, the rapidity of diffusion attainable in systems of small dimensions is the basis of the capillary circulation, and therewith of the whole design of the larger animals; and the rate at which diffusion an supply oxygen to a fatigued muscle for the removal of lactic acid is an important factor in determining the speed at which recovery can occur.

scholarly journals Equilibrium Study on Reactive Extraction of Lactic Acid with Tri-n – Butyl Phosphate in n - Hexane

2013 ◽  
Vol 12 (2) ◽  
pp. 1
Author(s):  
Panut Mulyono ◽  
Anita Pardah
Keyword(s):  
Aqueous Solution ◽  
Lactic Acid ◽  
Ambient Temperature ◽  
Carboxylic Acids ◽  
Distribution Ratio ◽  
Equilibrium Constants ◽  
Reactive Extraction ◽  
Extraction Temperature ◽  
Process Selection ◽  
Initial Concentration

Extraction of carboxylic acids from dilute aqueous solution using traditional solvents such as ketones, alcohols, ethers, and ester is inefficient because the distribution ratio is rather low. Reactive extraction which exploits reversible chemical complexation is an effective separation process for extraction of carboxylic acids from aqueous streams such as fermentation broths and wastewaters. In the extraction process, selection of the solvent is an important aspect to be considered. Considering its solubility in water, cost and availability, tri-n-butyl phosphate (TBP) seems to be an attractive solvent for the extraction of lactic acid from aqueous solution. The purpose of this experiment is to study the equilibrium of the reactive extraction of lactic acid in aqueous solution with TBP in n-hexane. The parameters studied in this experiment were initial concentration of lactic acid in the aqueous phase, TBP concentration in n-hexane phase, and the extraction temperature. The experiments at ambient temperature were carried out using a separatory funnel, while the experiments at other than ambient temperature were carried out using erlenmeyer flask and water bath shaker to adjust the temperature. In this experiment, the initial concentration of lactic acid was varied from 0.1 to 0.5 gmol/dm3. The range of initial TBP concentrations in n-hexane was 0.1 to 1.0 gmol/dm3 and the extraction temperature range was 283 to 313 K. The experimental results showed that the higher the initial concentration of lactic acid in aqueous solution, the higher the distribution ratio for a fixed TBP concentration and extraction temperature. For a fixed initial concentration of lactic acid in aqueous solution and extraction temperature, the distribution ratio of lactic acid is increased by increasing TBP concentration. The overall equilibrium constants (Kpq) for the experiments using TBP concentration ranging from 0.1 to 1.0 gmol/dm3 at the extraction temperature of 293 K are calculated to be 0.0668 to 0.5144. Kpq for the experiments at the temperature ranging from 283 to 313 K at the initial concentration of lactic acid of 0.2 gmol/L are found to be 0.0122 to 0.8856. The Kpq as a function of temperature (T) in K can be expressed as ln Kpq = 10,596/T - 38.08 with sum of square of error of 0.14.

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