Rat and Human Natural Killers Exhibit Contrasting Immunoglobulin G Subclass Specificities in Antibody-Dependent Cellular Cytotoxicity Reflecting Differences in Their Fc Receptors (FcγR)

1990 ◽  
Vol 48 (6) ◽  
pp. 524-530 ◽  
Author(s):  
Elizabeth S. Song ◽  
Katrina Young ◽  
Duane W. Sears
Keyword(s):  
Immunoglobulin G ◽  
Fc Receptors ◽  
Cellular Cytotoxicity ◽  
Natural Killers ◽  
Antibody Dependent Cellular Cytotoxicity ◽  
Immunoglobulin G Subclass

scholarly journals Studies in acute leukemia. I. Antibody-dependent and spontaneous cellular cytotoxicity by leukemic blasts from patients with acute nonlymphoid leukemia

Blood ◽  
1979 ◽  
Vol 54 (3) ◽  
pp. 573-580
Author(s):  
G Fernandes ◽  
T Garrett ◽  
M Nair ◽  
D Straus ◽  
RA Good ◽  
...  
Keyword(s):  
Fc Receptors ◽  
Surface Antigens ◽  
Leukemic Cells ◽  
Acute Monocytic Leukemia ◽  
Cellular Cytotoxicity ◽  
Antibody Dependent Cellular Cytotoxicity ◽  
Adcc Activity ◽  
Monocytic Leukemia ◽  
K562 Cell Line ◽  
Cell Surface Antigens

Leukemic blasts from patients with acute nonlymphoid leukemia were examined for the presence of Ig, receptors for IgGFc, and for their capacity to mediate antibody-dependent cellular cytotoxicity (ADCC) against chicken red blood cells (RBC) coated with IgG and spontaneous cell-mediated cytotoxicity (SCMC) against cells of K562 cell line. Leukemic blasts from acute myeloblastic leukemia (AML) patients lacked both Fc receptors and Ig on their surface, had no SCMC activity and majority, but not all of them, lacked ADCC activity. Leukemic blasts from patients with acute monocytic leukemia (AMOL) had Fc receptors, and 50% had IgG on their surface. IgG was cytophilic and appeared not to be directed against cell-surface antigens. This antibody did not interfere with the ADCC activity of leukemic cells. Leukemic blasts from majority of patients with AMOL mediated ADCC, but had no SCMC activity. An association between ADCC and presence of Fc receptor was observed.

Cytokine effects and role of adhesive proteins and Fc receptors in human macrophage-mediated antibody dependent cellular cytotoxicity

1991 ◽  
Vol 45 (4) ◽  
pp. 381-390 ◽  
Author(s):  
Jane L. Liesveld ◽  
Karen E. Frediani ◽  
Jill M. Winslow ◽  
Camille N. Abboud ◽  
Reggie E. Duerst
Keyword(s):  
Fc Receptors ◽  
Human Macrophage ◽  
Cellular Cytotoxicity ◽  
Antibody Dependent Cellular Cytotoxicity ◽  
Adhesive Proteins

Studies in acute leukemia. I. Antibody-dependent and spontaneous cellular cytotoxicity by leukemic blasts from patients with acute nonlymphoid leukemia

Blood ◽  
1979 ◽  
Vol 54 (3) ◽  
pp. 573-580 ◽  
Author(s):  
G Fernandes ◽  
T Garrett ◽  
M Nair ◽  
D Straus ◽  
RA Good ◽  
...  
Keyword(s):  
Fc Receptors ◽  
Surface Antigens ◽  
Leukemic Cells ◽  
Acute Monocytic Leukemia ◽  
Cellular Cytotoxicity ◽  
Antibody Dependent Cellular Cytotoxicity ◽  
Adcc Activity ◽  
Monocytic Leukemia ◽  
K562 Cell Line ◽  
Cell Surface Antigens

Abstract Leukemic blasts from patients with acute nonlymphoid leukemia were examined for the presence of Ig, receptors for IgGFc, and for their capacity to mediate antibody-dependent cellular cytotoxicity (ADCC) against chicken red blood cells (RBC) coated with IgG and spontaneous cell-mediated cytotoxicity (SCMC) against cells of K562 cell line. Leukemic blasts from acute myeloblastic leukemia (AML) patients lacked both Fc receptors and Ig on their surface, had no SCMC activity and majority, but not all of them, lacked ADCC activity. Leukemic blasts from patients with acute monocytic leukemia (AMOL) had Fc receptors, and 50% had IgG on their surface. IgG was cytophilic and appeared not to be directed against cell-surface antigens. This antibody did not interfere with the ADCC activity of leukemic cells. Leukemic blasts from majority of patients with AMOL mediated ADCC, but had no SCMC activity. An association between ADCC and presence of Fc receptor was observed.

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