Maintenance of Human Immunodeficiency Virus Type-1 Proviral DNA in Human Fetal Dorsal Root Ganglia Neural Cells Following a Nonproductive Infection

1991 ◽  
Vol 49 (5) ◽  
pp. 505-510 ◽  
Author(s):  
Charles Kunsch ◽  
Brian Wigdahl
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Neural Cells ◽  
Proviral Dna ◽  
Immunodeficiency Virus

scholarly journals Mutations in the Primer Grip of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Impair Proviral DNA Synthesis and Virion Maturation

1998 ◽  
Vol 72 (9) ◽  
pp. 7676-7680 ◽  
Author(s):  
Qiang Yu ◽  
Michele Ottmann ◽  
Christine Pechoux ◽  
Stuart Le Grice ◽  
Jean-Luc Darlix
Keyword(s):  
Human Immunodeficiency Virus ◽  
Reverse Transcriptase ◽  
Dna Synthesis ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Virus Assembly ◽  
Conserved Residues ◽  
Proviral Dna ◽  
Immunodeficiency Virus

ABSTRACT This report describes the effects of mutating highly conserved residues in the primer grip domain of human immunodeficiency virus type 1 reverse transcriptase (RT) on virus formation and infectivity. Among a series of RT mutant viruses, three (M230A, L234D, and W239A) were found to be noninfectious or very poorly infectious. Our data indicate that these mutations in RT caused severe defects in proviral DNA synthesis. Interestingly, assembly and maturation of mutant virus M230A were similar to those of the wild type, while mutants L234D and W239A showed impaired maturation. The immature morphology of RT mutants L234D and W239A is due at least in part to premature cleavage of the gag-pol precursor, prior to virion budding, indicating that intracellular stability of Pr160 gag-pol is of key importance during virus assembly.

Analysis of the junctions between human immunodeficiency virus type 1 proviral DNA and human DNA.

1990 ◽  
Vol 64 (11) ◽  
pp. 5626-5627 ◽  
Author(s):  
C Vink ◽  
M Groenink ◽  
Y Elgersma ◽  
R A Fouchier ◽  
M Tersmette ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Proviral Dna ◽  
Human Dna ◽  
Immunodeficiency Virus
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