Imaging mass spectrometry of gold nanoparticles in a tissue section as an immunohistochemical staining mass probe

2018 ◽  
Vol 54 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Daiki Muko ◽  
Takanori Ikenaga ◽  
Masanori Kasai ◽  
Janice B. Rabor ◽  
Atsushi Nishitani ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gold Nanoparticles ◽  
Tissue Section ◽  
Immunohistochemical Staining ◽  
Imaging Mass Spectrometry

Fluorinated Gold Nanoparticles for Nanostructure Imaging Mass Spectrometry

ACS Nano ◽  
2018 ◽  
Vol 12 (7) ◽  
pp. 6938-6948 ◽  
Author(s):  
Amelia Palermo ◽  
Erica M. Forsberg ◽  
Benedikt Warth ◽  
Aries E. Aisporna ◽  
Elizabeth Billings ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gold Nanoparticles ◽  
Imaging Mass Spectrometry

Multimodal chemical imaging of a single brain tissue section using ToF-SIMS, MALDI-ToF and immuno/histochemical staining

The Analyst ◽  
2021 ◽  
Author(s):  
Ibrahim Kaya ◽  
Eva Jennische ◽  
Stefan Lange ◽  
Per Malmberg
Keyword(s):  
Mass Spectrometry ◽  
Brain Tissue ◽  
Tissue Section ◽  
Imaging Mass Spectrometry ◽  
Chemical Imaging ◽  
Histochemical Staining ◽  
Maldi Tof ◽  
Tof Sims ◽  
Brain Tissue Section

ToF-SIMS and/or MALDI-ToF imaging mass spectrometry of a single brain tissue section followed by classical- or immuno- histochemical staining.

Gold Nanoparticles and Imaging Mass Spectrometry: Double Imaging of Latent Fingerprints

2010 ◽  
Vol 82 (5) ◽  
pp. 1589-1593 ◽  
Author(s):  
Ho-Wai Tang ◽  
Wei Lu ◽  
Chi-Ming Che ◽  
Kwan-Ming Ng
Keyword(s):  
Mass Spectrometry ◽  
Gold Nanoparticles ◽  
Imaging Mass Spectrometry ◽  
Latent Fingerprints

Spatial Metabolomics of the Human Kidney Using MALDI Trapped Ion Mobility Imaging Mass Spectrometry

2020 ◽  
Author(s):  
Elizabeth Neumann ◽  
Lukasz Migas ◽  
Jamie L. Allen ◽  
Richard Caprioli ◽  
Raf Van de Plas ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Imaging Mass Spectrometry ◽  
Structural Complexity ◽  
Human Kidney ◽  
Resolving Power ◽  
Mobility Separation ◽  
Trapped Ion ◽  
Mobility Data ◽  
Ion Mobility Separation

<div> <div> <p>Small metabolites are essential for normal and diseased biological function but are difficult to study because of their inherent structural complexity. MALDI imaging mass spectrometry (IMS) of small metabolites is particularly challenging as MALDI matrix clusters are often isobaric with metabolite ions, requiring high resolving power instrumentation or derivatization to circumvent this issue. An alternative to this is to perform ion mobility separation before ion detection, enabling the visualization of metabolites without the interference of matrix ions. Here, we use MALDI timsTOF IMS to image small metabolites at high spatial resolution within the human kidney. Through this, we have found metabolites, such as arginic acid, acetylcarnitine, and choline that localize to the cortex, medulla, and renal pelvis, respectively. We have also demonstrated that trapped ion mobility spectrometry (TIMS) can resolve matrix peaks from metabolite signal and separate both isobaric and isomeric metabolites with different localizations within the kidney. The added ion mobility data dimension dramatically increased the peak capacity for molecular imaging experiments. Future work will involve further exploring the small metabolite profiles of human kidneys as a function of age, gender, and ethnicity.</p></div></div>

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