Detection and genotyping of human herpes simplex viruses in cutaneous lesions of erythema multiforme by nested PCR

2003 ◽  
Vol 71 (3) ◽  
pp. 423-428 ◽  
Author(s):  
Yongjiang Sun ◽  
Roy Kum Wah Chan ◽  
Suat Hoon Tan ◽  
Patricia Pei Lin Ng
1989 ◽  
Vol 93 (1) ◽  
pp. 183-187 ◽  
Author(s):  
Sylvia L. Brice ◽  
Donna Krzemien ◽  
William L. Weston ◽  
J. Clark Huff

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Aya Mtiri ◽  
Ghada Bouslama ◽  
Nour-sayda Ben Messouad ◽  
Iyadh Abidi ◽  
Souha Ben Youssef ◽  
...  

Erythema multiforme is an acute mucocutaneous hypersensitivity reaction with various etiological factors, including herpes simplex virus, medications, autoimmune diseases, and malignancies, but the most common cause is infection by herpes simplex virus. The most characteristic feature is the presence of “target lesions.” There are no specific diagnostic tests for EM, and the diagnosis is based on clinical signs and symptoms and biopsy if required. We report a case of recurrent herpes-associated erythema multiforme managed with prophylactic acyclovir for 6 months: a 17-year-old boy had recurrent cutaneous lesions as well as lesions in the oral cavity and lips. Positive serology for herpes simplex virus and histopathological examination confirmed the diagnosis.


1992 ◽  
Vol 13 (3) ◽  
pp. 107-111
Author(s):  
Ann M. Arvin ◽  
Charles G. Prober

There are six recognized members of the human herpes group of viruses. These include type 1 and type 2 herpes simplex viruses (HSV-1 and HSV-2), cytomegalovirus (CMV), Epstein-Barr virus (EBV), varicellazoster virus (VZV), and human herpes virus type 6 (HHV-6). These ubiquitous double-stranded DNA viruses are relatively large and lipid-enveloped. The capacity to induce a state of latency in the infected host has been proved for all of the herpes viruses. That is, after primary infection, the viruses remain forever with the host with the possibility for subsequent reactivations. The mechanisms of these reactivations are not understood completely. Both primary infections and recurrences may be associated with clinical illness or may be asymptomatic. To a large extent, the status of the host immune system determines the severity of the infection and the likelihood of recurrences. In general, infections are more severe and recurrences are more frequent in the most compromised hosts. This review focuses on HSV-1 and HSV-2, with emphasis on neonatal infections and maternal genital infections as a source of infection in the newborn. The clinical illnesses caused by HSV-1 and HSV-2 are usually quite distinct. HSV-1 is the predominant cause of oral, ocular, and central nervous system infections occurring after the neonatal period, and HSV-2 is the predominant cause of genital and neonatal infections.


2014 ◽  
Vol 31 (9) ◽  
pp. 2356-2364 ◽  
Author(s):  
Joel O. Wertheim ◽  
Martin D. Smith ◽  
Davey M. Smith ◽  
Konrad Scheffler ◽  
Sergei L. Kosakovsky Pond

2020 ◽  
Author(s):  
Amanda M. Casto ◽  
Meei-Li Huang ◽  
Hong Xie ◽  
Keith R. Jerome ◽  
Anna Wald ◽  
...  

AbstractHuman herpes simplex viruses (HSV) 1 and 2 are most often typed via molecular assays. Here we describe the first known case of HSV mistyping due to a previously undescribed HSV-1 x HSV-2 recombination event in UL27, the gene that encodes glycoprotein B. This is the first reported HSV interspecies recombination event impacting this gene, which is frequently used as a target for diagnostics and experimental therapeutics.


2010 ◽  
Vol 221 (2) ◽  
pp. 193-200 ◽  
Author(s):  
Kirk Jensen ◽  
Aneeta Patel ◽  
Alexander Larin ◽  
Victoria Hoperia ◽  
Motoyasu Saji ◽  
...  

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