HIV-1 transmitted drug resistance and genetic diversity among patients from Piauí State, Northeast Brazil

Abstract BackgroundSeventeen years after the start of the IBAARV (Beninese initiative for access to antiretrovirals), transmitted drug resistance mutations in ARV naïve patients and HIV-1 genetic diversity were investigated in Benin.Methods353 plasma samples were collected between October and December 2017 in nineteen facilities care in Benin from HIV-1 positive and ARV naive individuals. Pol (protease + partial RT) region was amplified and sequenced in 248 samples.ResultsDrug resistance mutations were detected in (27/248; 10.9%) according to the WHO SDRM 2009 list, with predominance of mutations directed to NNRTIs drugs (24/248; 10%).Phylogenetic and recombination analyses showed a predominance of CRF02_AG strains (165/248; 66.5%) and a high genetic diversity with five other variants and 39 URFs (15.7%) which contained portions of strains that co-circulate in Benin. Eight recent transmission chains revealed active ongoing transmission of HIV-1 strains among ARV naïve patients.ConclusionsOur study showed a high primary drug resistance rate and a complex genetic diversity. Regular monitoring of primary drug resistance is required to adapt HIV-1 treatment strategies and adoption of new WHO recommendations in Benin.

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HIV-1 Genetic Diversity and Transmitted Drug Resistance Mutations in Female Sex Workers from a Brazilian Municipality in the Amazon Region

AIDS Research and Human Retroviruses ◽

10.1089/aid.2019.0243 ◽

2020 ◽

Vol 36 (2) ◽

pp. 99-100 ◽

Cited By ~ 1

Author(s):

Luana Mota da Costa ◽

Paula Cristina R. Frade ◽

Lucinaldo da Silva Blandtt ◽

Gláucia C. Silva-Oliveira ◽

Luiz Fernando A. Machado ◽

...

Keyword(s):

Genetic Diversity ◽

Drug Resistance ◽

Sex Workers ◽

Female Sex Workers ◽

Amazon Region ◽

Transmitted Drug Resistance ◽

Resistance Mutations ◽

Drug Resistance Mutations ◽

Female Sex ◽

Hiv 1

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HIV-1 Genetic Diversity and Transmitted Drug Resistance in Antiretroviral Treatment-Naive Individuals from Amapá State, Northern Brazil

AIDS Research and Human Retroviruses ◽

10.1089/aid.2015.0280 ◽

2016 ◽

Vol 32 (4) ◽

pp. 373-376 ◽

Cited By ~ 14

Author(s):

Lindomar dos Anjos Silva ◽

Flavia Divino ◽

Márlisson Octávio da Silva Rêgo ◽

Ivina Geselle Lima Lopes ◽

Cláudia Maria Nóbrega Costa ◽

...

Keyword(s):

Genetic Diversity ◽

Drug Resistance ◽

Antiretroviral Treatment ◽

Transmitted Drug Resistance ◽

Treatment Naïve ◽

Northern Brazil ◽

Hiv 1

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Genetic diversity of HIV-1 and transmitted drug resistance among newly diagnosed individuals with HIV infection in Hangzhou, China

Journal of Medical Virology ◽

10.1002/jmv.24223 ◽

2015 ◽

Vol 87 (10) ◽

pp. 1668-1676 ◽

Cited By ~ 7

Author(s):

Jiafeng Zhang ◽

Zhihong Guo ◽

Jiezhe Yang ◽

Xiaohong Pan ◽

Jun Jiang ◽

...

Keyword(s):

Genetic Diversity ◽

Drug Resistance ◽

Hiv Infection ◽

Transmitted Drug Resistance ◽

Newly Diagnosed ◽

Hiv 1

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Genetic Diversity and Transmitted Drug Resistance of HIV-1 Subtypes in Blood Donors Candidates in Northern Mozambique

Journal of AIDS & Clinical Research ◽

10.4172/2155-6113.1000623 ◽

2016 ◽

Vol 7 (10) ◽

Author(s):

Vubil A ◽

Jani VI ◽

Mabunda N ◽

Ismael N ◽

Ramalho D ◽

...

Keyword(s):

Genetic Diversity ◽

Drug Resistance ◽

Blood Donors ◽

Transmitted Drug Resistance ◽

Hiv 1

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Moderate rate of transmitted resistance mutations to antiretrovirals and genetic diversity in newly HIV-1 patients diagnosed in Benin.

10.21203/rs.3.rs-22911/v2 ◽

2020 ◽

Author(s):

EDMOND TCHIAKPE ◽

Rene K Keke ◽

Nicole Vidal ◽

Clément Ahoussinou ◽

Olga Sekpe ◽

...

Keyword(s):

Genetic Diversity ◽

Drug Resistance ◽

Treatment Strategies ◽

Transmitted Drug Resistance ◽

Resistance Mutations ◽

High Genetic Diversity ◽

Drug Resistance Mutations ◽

Primary Drug Resistance ◽

Hiv 1 ◽

Primary Drug

Abstract Objective Seventeen years after the start of the IBAARV (Beninese initiative for access to antiretrovirals), transmitted drug resistance mutations in ARV-naïve patients and HIV-1 genetic diversity were investigated in Benin. Results Drug resistance mutations were detected in (27/248; 10.9%) according to the WHO SDRM 2009 list, with a predominance of mutations directed against NNRTIs drugs (24/248; 10%). Phylogenetic and recombination analyses showed a predominance of CRF02_AG strains (165/248; 66.5%) and a high genetic diversity with five other variants and 39 URFs (15.7%) which contained portions of strains that co-circulate in Benin. Eight recent transmission chains revealed active ongoing transmission of HIV-1 strains among ARV-naïve patients.Our study showed a moderate primary drug resistance mutations rate and also provided recent data on the HIV-1 variants that circulate in Benin. Regular monitoring of primary drug resistance is required to adapt HIV-1 treatment strategies and adoption of new WHO recommendations in Benin.

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Moderate rate of transmitted resistance mutations to antiretrovirals and genetic diversity in newly HIV-1 patients diagnosed in Benin.

10.21203/rs.3.rs-22911/v3 ◽

2020 ◽

Author(s):

EDMOND TCHIAKPE ◽

Rene K Keke ◽

Nicole Vidal ◽

Clément Ahoussinou ◽

Olga Sekpe ◽

...

Keyword(s):

Genetic Diversity ◽

Drug Resistance ◽

Treatment Strategies ◽

Transmitted Drug Resistance ◽

Resistance Mutations ◽

High Genetic Diversity ◽

Drug Resistance Mutations ◽

Primary Drug Resistance ◽

Hiv 1 ◽

Primary Drug

Abstract Objective Seventeen years after the start of the IBAARV (Beninese initiative for access to antiretrovirals), transmitted drug resistance mutations in ARV naïve patients and HIV-1 genetic diversity were investigated in Benin. Results Drug resistance mutations were detected in (27/248; 10.9%) according to the WHO SDRM 2009 list, with a predominance of mutations directed to NNRTIs drugs (24/248; 10%). Phylogenetic and recombination analyses showed a predominance of CRF02_AG strains (165/248; 66.5%) and a high genetic diversity with five other variants and 39 URFs (15.7%) which contained portions of strains that co-circulate in Benin. Eight recent transmission chains revealed active ongoing transmission of HIV-1 strains among ARV naïve patients. Our study showed a moderate primary drug resistance mutations rate and also provided recent data on the HIV-1 variants that circulate in Benin. Regular monitoring of primary drug resistance is required to adapt HIV-1 treatment strategies and adoption of new WHO recommendations in Benin.

Download Full-text