Moisture-Induced Surface Crystallization of Spray-Dried Amorphous Lactose Particles Studied by Atomic Force Microscopy

2004 ◽  
Vol 93 (1) ◽  
pp. 29-37 ◽  
Author(s):  
Denny Mahlin ◽  
Jonas Berggren ◽  
Göran Alderborn ◽  
Sven Engström
Keyword(s):  
Atomic Force Microscopy ◽  
Surface Crystallization ◽  
Force Microscopy ◽  
Atomic Force ◽  
Amorphous Lactose ◽  
Spray Dried

scholarly journals An investigation of surface properties, local elastic modulus and interaction with simulated pulmonary surfactant of surface modified inhalable voriconazole dry powders using atomic force microscopy

RSC Advances ◽  
2016 ◽  
Vol 6 (31) ◽  
pp. 25789-25798 ◽  
Author(s):  
Sumit Arora ◽  
Michael Kappl ◽  
Mehra Haghi ◽  
Paul M. Young ◽  
Daniela Traini ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Elastic Modulus ◽  
Surface Properties ◽  
Pulmonary Surfactant ◽  
Dry Powders ◽  
Force Microscopy ◽  
Atomic Force ◽  
Surface Modified ◽  
Spray Dried

l-Leucine modified voriconazole spray dried micropartcles.

Material Analysis by Ultrasonic Atomic Force Microscopy

2000 ◽  
Vol 627 ◽  
Author(s):  
Chiaki Miyasaka ◽  
Lily Jia ◽  
Bernhard R. Tittmann
Keyword(s):  
Atomic Force Microscopy ◽  
Surface Layer ◽  
Diagnostic Tool ◽  
Ceramic Powders ◽  
Detailed Structure ◽  
Force Microscopy ◽  
Nano Indentation ◽  
Atomic Force ◽  
Good Contrast ◽  
Spray Dried

ABSTRACTSpray-dried ceramic powders (e.g., Al2O3) are composed of a plurality of granules, each of which, includes ceramic particles and organic binders. It is assumed that the binders become concentrated in the surface layer of the granule in accordance with its type or its volume mixed into a ceramic portion of the granule. However, evidence to prove the assumption was limited because conventional microscopes were not able to clearly visualize the segregation. This paper presents a technique for imaging detailed structure of the spray-dried ceramic powders with the ultrasonic-atomic force microscope (U-AFM). The distribution of binder vis-a-vis Al2O3 particles is highly resolved with good contrast. The distribution was confirmed by nano -indentation. Thus, the U-AFM is shown to be a useful diagnostic tool for the development of approaches to spray-dried process evaluation.

Determination of the Surface Free Energy of Crystalline and Amorphous Lactose by Atomic Force Microscopy Adhesion Measurement

2006 ◽  
Vol 23 (2) ◽  
pp. 401-407 ◽  
Author(s):  
Jianxin Zhang ◽  
Stephen Ebbens ◽  
Xinyong Chen ◽  
Zheng Jin ◽  
Shen Luk ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Free Energy ◽  
Surface Free Energy ◽  
Force Microscopy ◽  
Atomic Force ◽  
Adhesion Measurement ◽  
Amorphous Lactose

Analysis of organic binder distribution in spray-dried granules by ultrasonic-atomic force microscopy

1999 ◽  
Author(s):  
Lili Jia ◽  
Michael Mandanas ◽  
Chiaki Miyasaka ◽  
Bernhard R. Tittmann ◽  
Gary L. Messing
Keyword(s):  
Atomic Force Microscopy ◽  
Organic Binder ◽  
Force Microscopy ◽  
Atomic Force ◽  
Spray Dried
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