Postmarketing In Vitro/In Vivo Assessment of Fixed Dose Combination Products of First Line Antiretrovirals

2010 ◽  
Vol 99 (6) ◽  
pp. 2655-2663 ◽  
Author(s):  
A. Joshi ◽  
F. Esseku ◽  
L. Silva ◽  
C. Igwilo ◽  
D. Oqua ◽  
...  
Keyword(s):  
Fixed Dose Combination ◽  
Fixed Dose ◽  
First Line ◽  
Dose Combination ◽  
In Vivo Assessment

Multi-kinetics and site-specific release of gabapentin and flurbiprofen from oral fixed-dose combination: in vitro release and in vivo food effect

2017 ◽  
Vol 262 ◽  
pp. 296-304 ◽  
Author(s):  
Fabio Sonvico ◽  
Chiara Conti ◽  
Gaia Colombo ◽  
Francesca Buttini ◽  
Paolo Colombo ◽  
...  
Keyword(s):  
Food Effect ◽  
In Vitro Release ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Site Specific ◽  
Dose Combination ◽  
Vitro Release

scholarly journals Development, Characterization and In Vivo Pharmacokinetic Assessment of Rectal Suppositories Containing Combination Antiretroviral Drugs for HIV Prevention

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1110
Author(s):  
Kunal Jhunjhunwala ◽  
Charles W. Dobard ◽  
Sunita Sharma ◽  
Natalia Makarova ◽  
Angela Holder ◽  
...  
Keyword(s):  
Hiv Prevention ◽  
Antiretroviral Drugs ◽  
Water Soluble ◽  
Fixed Dose ◽  
Receptive Anal Intercourse ◽  
On Demand ◽  
Dose Combination ◽  
Rectal Suppositories

Receptive anal intercourse (RAI) contributes significantly to HIV acquisition underscoring the need to develop HIV prevention options for populations engaging in RAI practices. We explored the feasibility of formulating rectal suppositories with potent antiviral drugs for on-demand use. A fixed-dose combination of tenofovir (TFV) and elvitegravir (EVG) (40 mg each) was co-formulated in six different suppository bases (three fat- and three water-soluble). Fat-soluble witepsol H15 and water-soluble polyethylene glycol (PEG) based suppositories demonstrated favorable in vitro release and were advanced to assess in vivo pharmacokinetics following rectal administration in macaques. In vivo drug release profiles were similar for both suppository bases. Median concentrations of TFV and EVG detected in rectal fluids at 2 h were 1- and 2-logs higher than the in vitro IC50, respectively; TFV-diphosphate levels in rectal tissues met or exceeded those associated with high efficacy against rectal simian HIV (SHIV) exposure in macaques. Leveraging on these findings, a PEG-based suppository with a lower dose combination of tenofovir alafenamide (TAF) and EVG (8 mg each) was developed and found to achieve similar rectal drug exposures in macaques. This study establishes the utility of rectal suppositories as a promising on-demand strategy for HIV PrEP and supports their clinical development.

Are fixed-dose combination antihypertensives suitable as first-line therapy?

2012 ◽  
Vol 28 (10) ◽  
pp. 1685-1697 ◽  
Author(s):  
Sverre E. Kjeldsen ◽  
Franz H. Messerli ◽  
Chern-En Chiang ◽  
Peter A. Meredith ◽  
Lisheng Liu
Keyword(s):  
Fixed Dose Combination ◽  
Fixed Dose ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy ◽  
Dose Combination

In Vitro Microbial Efficacy of Sulbactomax: A Novel Fixed Dose Combination of Ceftriaxone Sulbactam and Ceftriaxone Alone

2009 ◽  
Vol 4 (1) ◽  
pp. 73-77 ◽  
Author(s):  
Sanjay Shrivastava ◽  
Sandeep Saurabh ◽  
Dharmendra Rai ◽  
Vivek Dwivedi ◽  
Manu Chaudhary
Keyword(s):  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Dose Combination

scholarly journals In vitro Evaluation of Trimethoprim and Sulfamethoxazole from Fixed-Dose Combination Generic Drugs using Spectrophotometry: Comparison of Flow-Through Cell and USP Paddle Methods

2015 ◽  
Vol 14 (11) ◽  
pp. 2061 ◽  
Author(s):  
Raúl Medina ◽  
Maximiliano Miranda ◽  
Marcela Hurtado ◽  
Adriana M Domínguez- Ramírez ◽  
Octavio Reyes ◽  
...  
Keyword(s):  
Generic Drugs ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Dose Combination ◽  
Flow Through
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