scholarly journals Thiol–Disulfide Exchange in Peptides Derived from Human Growth Hormone During Lyophilization and Storage in the Solid State

2015 ◽  
Vol 104 (4) ◽  
pp. 1291-1302 ◽  
Author(s):  
Saradha Chandrasekhar ◽  
Elizabeth M. Topp
Keyword(s):  
Growth Hormone ◽  
Solid State ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Disulfide Exchange ◽  
And Storage

Effects of a fragment of human growth hormone-releasing factor in normal and 'Little' mice

1985 ◽  
Vol 106 (1) ◽  
pp. 1-5 ◽  
Author(s):  
R. G. Clark ◽  
I. C. A. F. Robinson
Keyword(s):  
Growth Hormone ◽  
Growth Rate ◽  
Pituitary Gland ◽  
Human Growth Hormone ◽  
Anterior Pituitary ◽  
Human Growth ◽  
Body Growth ◽  
Stimulus Secretion Coupling ◽  
And Storage ◽  
Little Mouse

ABSTRACT The 'Little' mouse is characterized by a body growth rate 60% of normal due to a defect in the synthesis and storage of GH in the anterior pituitary gland. We have now investigated the effects of GH releasing factor (GRF) in these mice and in normal animals. The pituitary GH content in Little mice was only 4% of that in normal C57: +/+ mice, and was not affected by twice daily i.p. injections of human (h) GRF1-29NH2 (0·2−2 μg) for 14 days. This treatment also had no effect on body growth. In anaesthetized normal mice, single i.v. injections of 0·1 or 2 μg hGRF1-29NH2 released large amounts of GH into the plasma, whereas this peptide was ineffective in Little mice, whether or not they had been pretreated with GRF. Therefore, although pituitaries of Little mice contain significant amounts of GH, this pool is not releasable by GRF. This suggests that the dwarfism in Little mice may be partly due to a pituitary defect in GRF receptors or their stimulus-secretion coupling, rather than a deficiency in hypothalamic GRF. J. Endocr. (1985) 106, 1–5

scholarly journals Thiol–Disulfide Exchange in Peptides Derived from Human Growth Hormone

2014 ◽  
Vol 103 (4) ◽  
pp. 1032-1042 ◽  
Author(s):  
Saradha Chandrasekhar ◽  
Daniel E. Epling ◽  
Andreas M. Sophocleous ◽  
Elizabeth M. Topp
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Disulfide Exchange

scholarly journals Thiol-Disulfide Exchange in Human Growth Hormone

2016 ◽  
Vol 33 (6) ◽  
pp. 1370-1382 ◽  
Author(s):  
Saradha Chandrasekhar ◽  
Balakrishnan S. Moorthy ◽  
Ruichao Xie ◽  
Elizabeth M. Topp
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Disulfide Exchange
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