scholarly journals Intradiscal injection for the management of low back pain

JOR Spine ◽  
2021 ◽  
Author(s):  
Fu Zhang ◽  
Songjuan Wang ◽  
Baoliang Li ◽  
Wei Tian ◽  
Zhiyu Zhou ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Low Back ◽  
Intradiscal Injection

scholarly journals Intradiscal Injection of Autologous Platelet-Rich Plasma Releasate to Treat Discogenic Low Back Pain: A Preliminary Clinical Trial

2017 ◽  
Vol 11 (3) ◽  
pp. 380-389 ◽  
Author(s):  
Koji Akeda ◽  
Kohshi Ohishi ◽  
Koichi Masuda ◽  
Won C. Bae ◽  
Norihiko Takegami ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Platelet Rich Plasma ◽  
Low Back ◽  
Discogenic Low Back Pain ◽  
Intradiscal Injection ◽  
Autologous Platelet Rich Plasma ◽  
The Mean ◽  
Autologous Platelet

<sec><title>Study Design</title><p>Preliminary clinical trial.</p></sec><sec><title>Purpose</title><p>To determine the safety and initial efficacy of intradiscal injection of autologous platelet-rich plasma (PRP) releasate in patients with discogenic low back pain.</p></sec><sec><title>Overview of Literature</title><p>PRP, which is comprised of autologous growth factors and cytokines, has been widely used in the clinical setting for tissue regeneration and repair. PRP has been shown <italic>in vitro</italic> and <italic>in vivo</italic> to potentially stimulate intervertebral disc matrix metabolism.</p></sec><sec><title>Methods</title><p>Inclusion criteria for this study included chronic low back pain without leg pain for more than 3 months; one or more lumbar discs (L3/L4 to L5/S1) with evidence of degeneration, as indicated via magnetic resonance imaging (MRI); and at least one symptomatic disc, confirmed using standardized provocative discography. PRP releasate, isolated from clotted PRP, was injected into the center of the nucleus pulposus. Outcome measures included the use of a visual analog scale (VAS) and the Roland-Morris Disability Questionnaire (RDQ), as well as X-ray and MRI (T2-quantification).</p></sec><sec><title>Results</title><p>Data were analyzed from 14 patients (8 men and 6 women; mean age, 33.8 years). The average follow-up period was 10 months. Following treatment, no patient experienced adverse events or significant narrowing of disc height. The mean pain scores before treatment (VAS, 7.5±1.3; RDQ, 12.6±4.1) were significantly decreased at one month, and this was generally sustained throughout the observation period (6 months after treatment: VAS, 3.2±2.4, RDQ; 3.6±4.5 and 12 months: VAS, 2.9±2.8; RDQ, 2.8±3.9; <italic>p</italic>&lt;0.01, respectively). The mean T2 values did not significantly change after treatment.</p></sec><sec><title>Conclusions</title><p>We demonstrated that intradiscal injection of autologous PRP releasate in patients with low back pain was safe, with no adverse events observed during follow-up. Future randomized controlled clinical studies should be performed to systematically evaluate the effects of this therapy.</p></sec>

scholarly journals Implication of Two Different Doses of Intradiscal Ozone-Oxygen Injection upon the Pain Alleviation in Patients with Low Back Pain: A Randomized, Single-Blind Study

2018 ◽  
Vol 1 (21;1) ◽  
pp. E25-E31 ◽  
Author(s):  
Emad Zarief Kamel
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Disc Herniation ◽  
Blind Study ◽  
Pain Clinic ◽  
Oxygen Mixture ◽  
Low Back ◽  
Intradiscal Injection ◽  
Single Blind ◽  
Different Doses

Background: Low back pain (LBP) is mostly induced by disc herniation (DH) or degeneration and has a burden upon social activity and economical aspects of life. An abundance of medical and surgical interventions have evolved to resolve this problem, but one of the newly introduced techniques, which is the minimally invasive, low cost ozone-oxygen mixture (O3 -O2 ) intradiscal injection, offers a rapid onset amelioration of symptoms with a sustained duration of pain relief. Objective: We aim to evaluate the quality of pain alleviation using 2 different doses of intradiscal injections of O3 -O2 mixture. Study Design: A prospectively randomized, single-blind study. Setting: Pain clinic, anesthesia, intensive care, and pain department in Assiut University Hospitals. Methods: Sixty patients with symptomatizing single lumbar DH were subjected to O3 -O2 intradiscal injection and randomly allocated into one of 2 groups; group A: received 10 mL, 40 µg/ mL of O3 -O2 and group B: received 10 mL, 30 µg/mL of O3 -O2 . Pain score and functional ability of the patients using the visual analog scale (VAS) and Oswestry Disability Index (ODI) were evaluated after 1, 6, and 12 months and compared to the basal values. Patient satisfaction and reduction of DH were evaluated after the sixth month. Results: There were no significant differences between the 2 groups regarding the clinical outcome; however both the ODI and VAS evaluations showed highly significant improvement (decreased) (P < 0.01) after injection and during the entire follow-up period. There were highly significant negative correlations between the DH reduction percentage and both the VAS and ODI scores after 6 months in both of the groups. Limitations: This study was limited by a small sample size; it was also an active control trial, which may explain the insignificant difference in between the groups, in addition to being a singleblind trial. Conclusion: Intradiscal injection of O3 -O2 mixture is a very valuable maneuver in the reduction of DH size and improvement of pain quality, with either ozone concentrations of 40 µg/mL or 30 µg/mL. Key words: Low back pain, ozone, disc herniation

scholarly journals Intradiscal Injection of a Slow Release Formulation of Celecoxib for the Treatment of Dogs with Low Back Pain

2016 ◽  
Vol 6 (1_suppl) ◽  
pp. s-0036-1582632-s-0036-1582632
Author(s):  
Anna Tellegen ◽  
Martijn Beukers ◽  
Alberto Miranda-Bedate ◽  
Nicole Willems ◽  
Mike De Leeuw ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Slow Release ◽  
Low Back ◽  
Release Formulation ◽  
Slow Release Formulation ◽  
Intradiscal Injection

scholarly journals Intradiscal injection of a slow release formulation of celecoxib for the treatment of dogs with low back pain

2016 ◽  
Vol 24 ◽  
pp. S480
Author(s):  
A.R. Tellegen ◽  
M. Beukers ◽  
A. Miranda-Bedate ◽  
G.C. Grinwis ◽  
L.B. Creemers ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Slow Release ◽  
Low Back ◽  
Release Formulation ◽  
Slow Release Formulation ◽  
Intradiscal Injection

Lumbosacral immobilization following glucocorticoid intradiscal injection in patients with chronic low back pain and active discopathy: A feasibility study

2020 ◽  
Vol 33 (6) ◽  
pp. 931-937
Author(s):  
Emmanuel Couzi ◽  
Margaux Boisson ◽  
François Segretin ◽  
Marie-Martine Lefèvre-Colau ◽  
Alexandra Roren ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Feasibility Study ◽  
Chronic Low Back Pain ◽  
Long Term Results ◽  
Control Group ◽  
Low Back ◽  
Early Withdrawal ◽  
Intradiscal Injection ◽  
Experimental Group

BACKGROUND: In people with chronic low back pain (cLBP) and active discopathy, glucocorticoid intradiscal injection (GC IDI) reduces LBP in the short-term. Lumbosacral immobilization may be useful to obtain long-term results. OBJECTIVE: To assess the feasibility of a lumbosacral immobilization using a pantaloon cast following GC IDI in people with cLBP sand active discopathy. METHODS: We conducted a retrospective feasibility study. Participants were allocated to experimental or control groups by preferences. The experimental group received lumbosacral immobilization using a custom-made pantaloon cast worn continuously for one week following a GC IDI of 25 mg of prednisolone acetate. The control group received GC IDI alone. The primary endpoint was the feasibility of lumbosacral immobilization assessed by the rate of refusal and early withdrawal of the cast. RESULTS: Twelve patients were offered lumbosacral immobilization following GC IDI: the rate of refusal was 3/12 (25.0%) and was 3/9 (33.3%) of early withdrawal. Mean (95% CI) acceptability of the procedure was 55.0 (26.9–83.1)/100 in the experimental group (N= 6) and 61.6 (25.1–98.2)/100 in the control group (N= 6). CONCLUSIONS: We found high rates of refusal and early withdrawal of the lumbosacral immobilization using a pantaloon cast following GC IDI in people with nonspecific cLBP and active discopathy.

CT-Guided Intradiscal Injection of Ozone To Treat Low Back Pain Secondary To Herniated Disc. A Review.

2020 ◽  
Author(s):  
Giuseppe M Giannatempo ◽  
Ettore Serricchio, MD ◽  
Teresa Popolizio ◽  
Anna Simeone
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Herniated Disc ◽  
Low Back ◽  
Ct Guided ◽  
Intradiscal Injection

scholarly journals Injection of platelet rich plasma for low backpain caused by lumbar disc degeneration: a prospective study

2020 ◽  
Vol 6 (5) ◽  
pp. 1032
Author(s):  
M. Shanmugam ◽  
Shivakumar .
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Disc Degeneration ◽  
Platelet Rich Plasma ◽  
Lumbar Disc ◽  
Functional Improvement ◽  
Low Back ◽  
Lumbar Disc Degeneration ◽  
Intradiscal Injection ◽  
A Prospective Study

<p class="abstract"><strong>Background:</strong> Though the etiologies of chronic low back pain can be diverse, lumbar disc degeneration is one of the important causes of low backpain. In intractable cases of low back pain surgical interventions may be warranted. Intradiscal injection of platelet rich plasma is emerging as a novel treatment modality for chronic backpain and has been reported to have good results in terms of reduction of pain and improvement in functional abilities.</p><p class="abstract"><strong>Methods:</strong> This was a prospective study in which 30 patients with chronic low back pain were included. Platelet rich plasma was injected in nucleus pulposus of the affected part of lumbar spine under fluoroscopic control. Patients were followed up for 3 months. Reduction in severity of pain and functional improvement was assessed by Visual Analogue Scores (VAS) and Roland-Morris Low Back Pain and Disability Questionnaire (RDQ) scores.<strong></strong></p><p class="abstract"><strong>Results:</strong> The Mean age of the male patients was found to be 50.05±9.04 while the mean age of females was found to be 48.50±10.19. 18 (60%) patients were either overweight or obese. Remaining 12 (40%) patients had a normal BMI. The difference between mean VAS scores and RDQ scores at presentation and 3 months after PRP injection was found to be statistically highly significant (p&lt;0.0001).</p><p class="abstract"><strong>Conclusions:</strong> The intradiscal injection of platelet rich plasma in patients with low back pain secondary to lumbar disc degeneration is effective in reducing back pain and causing significant functional improvement.</p>

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