One Hundred Cases of Localized Laryngeal Amyloidosis ‐ Evidence for Future Management

AbstractAmyloidosis is a group of idiopathic clinical syndromes caused by the deposition of insoluble fibrillar proteins (amyloid) in the extracellular matrix of organs and tissues. These deposits disrupt the function of the target organ. Amyloidosis can manifest as a systemic disease or a single-organ involvement (local form). Its etiology still remains unclear. Deposits of amyloid in the larynx are rare, accounting for between 0.2 and 1.2% of benign tumors of the larynx. In this retrospective study, we report the clinical aspects, diagnosis, treatment and follow-up of five female patients with localized laryngeal amyloidosis without systemic involvement. The patients were all treated successfully using microlaryngoscopy with CO2 laser or cold instruments. Prognosis is excellent; however, appropriate follow-up is an important part of the long-term management of this disease in order to prevent and control the possibility of local recurrence.

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Localized laryngeal amyloidosis: Partial characterization of an amyloid fibril protein al

Molecular Immunology ◽

10.1016/0161-5890(82)90210-3 ◽

1982 ◽

Vol 19 (3) ◽

pp. 447-450 ◽

Cited By ~ 27

Author(s):

Per Westermark ◽

Knut Sletten ◽

Peter Pitkänen ◽

Jacob B. Natvig ◽

Carl-Eric Lindholm

Keyword(s):

Amyloid Fibril ◽

Partial Characterization ◽

Laryngeal Amyloidosis ◽

Amyloid Fibril Protein ◽

Localized Laryngeal Amyloidosis

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A Case of Recurrent Localized Laryngeal Amyloidosis

Practica Oto-Rhino-Laryngologica ◽

10.5631/jibirin.110.13 ◽

2017 ◽

Vol 110 (1) ◽

pp. 13-17

Author(s):

Akiko Ozaki ◽

Masaaki Higashino ◽

Norio Suzuki ◽

Tetsuya Terada ◽

Ryo Kawata ◽

...

Keyword(s):

Laryngeal Amyloidosis ◽

Localized Laryngeal Amyloidosis

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Localized Laryngeal Amyloidosis

International Journal of Phonosurgery & Laryngology ◽

10.5005/jp-journals-10023-1116 ◽

2016 ◽

Vol 6 (1) ◽

pp. 32-34

Author(s):

Gautam Khaund ◽

Ronica Baruah ◽

Abhijit Kalita

Keyword(s):

Head And Neck ◽

Vocal Cord ◽

Final Diagnosis ◽

Benign Disease ◽

Systemic Diseases ◽

Laryngeal Amyloidosis ◽

False Vocal ◽

Localized Laryngeal Amyloidosis

ABSTRACT Amyloidosis in head and neck is rare but a benign disease. Among the sites in head and neck, larynx is the most commonly involved. A 40-year-old female had presented with hoarseness of voice and dyspnea with a mass in false vocal cord, which was biopsied and diagnosed as amyloidosis. After excluding systemic diseases, final diagnosis of localized laryngeal amyloidosis was given. How to cite this article Baruah R, Khaund G, Kalita A. Localized Laryngeal Amyloidosis. Int J Phonosurg Laryngol 2016;6(1):32-34.

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Primary Localized Laryngeal Amyloidosis (LA)

Blood ◽

10.1182/blood.v118.21.4596.4596 ◽

2011 ◽

Vol 118 (21) ◽

pp. 4596-4596

Author(s):

Matthew Richards ◽

Kim Le ◽

Mercedes Lorenzo-Medina ◽

Langsjoen Dane ◽

Carmen Arango ◽

...

Keyword(s):

Vocal Cord ◽

Conflicts Of Interest ◽

Polarized Light ◽

Rare Condition ◽

B Cell Lymphoma ◽

Laryngeal Amyloidosis ◽

The Right ◽

False Vocal ◽

Localized Laryngeal Amyloidosis

Abstract Abstract 4596 Background: Localized Laryngeal Amyloidosis (LA) is a rare condition. There is limited understanding of its natural history. Our aim is to report the clinical evolution of a patient diagnosed with localized LA. Methods: Case report. Results: In May 2002, a 43-year-old gentleman presented with hoarseness and a CT scan of the neck showed a thickening of the right vocal cord with a mass that measured 2.9 × 1.2 cm in widest diameter. The patient had this mass removed surgically and the pathology showed a positive Congo red staining and a positive birefringence under polarized light, diagnostic of amyloidosis. No evidence of systemic amyloidosis or an overt B-cell lymphoma was found in this patient. Patient lost follow-up until October 2008 when he was found to have soft tissue induration around the left false vocal cord area. The biopsy showed again amyloidosis. Conclusions: LA recurrences can manifest several years after initial diagnosis. Long-term follow-up is essential. Disclosures: No relevant conflicts of interest to declare.

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CO2-laser treatment of laryngeal amyloidosis

The Journal of Laryngology & Otology ◽

10.1258/002221503768200011 ◽

2003 ◽

Vol 117 (8) ◽

pp. 647-650 ◽

Cited By ~ 5

Author(s):

Gaetano Motta ◽

Francesco Antonio Salzano ◽

Sergio Motta ◽

Stefania Staibano

Keyword(s):

Laser Treatment ◽

Surgical Resection ◽

Co2 Laser ◽

Laser Surgery ◽

Laser Technique ◽

Female Patients ◽

Laryngeal Amyloidosis ◽

Highly Effective ◽

Co2 Laser Treatment ◽

Localized Laryngeal Amyloidosis

Four consecutive female patients (age: 14–47 years) with laryngeal amyloidosis, treated with endoscopic CO2-laser surgery, entered the study. All patients underwent periodic microlaryngoscopies following surgery to confirm the adequacy of the surgical resection. Recurrences or suspected lesions were resected and fibrin deposits were removed to prevent the formation of synechiae or healing adhesions. After two negative microlaryngoscopies, performed two months apart, the patients were followed-up approximately every six months over a period from six months to 18 years, with no evidence of recurrences. The endoscopic CO2-laser technique is highly effective in the treatment of localized laryngeal amyloidosis.

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