scholarly journals Focus on localized laryngeal amyloidosis: management of five cases

Open Medicine ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 327-332
Author(s):  
Massimo Mesolella ◽  
Gerardo Petruzzi ◽  
Sarah Buono ◽  
Grazia Salerno ◽  
Francesco Antonio Salzano ◽  
...  
Keyword(s):  
Systemic Disease ◽  
Clinical Aspects ◽  
Benign Tumors ◽  
Local Form ◽  
Systemic Involvement ◽  
Clinical Syndromes ◽  
Laryngeal Amyloidosis ◽  
And Control ◽  
Localized Laryngeal Amyloidosis

AbstractAmyloidosis is a group of idiopathic clinical syndromes caused by the deposition of insoluble fibrillar proteins (amyloid) in the extracellular matrix of organs and tissues. These deposits disrupt the function of the target organ. Amyloidosis can manifest as a systemic disease or a single-organ involvement (local form). Its etiology still remains unclear. Deposits of amyloid in the larynx are rare, accounting for between 0.2 and 1.2% of benign tumors of the larynx. In this retrospective study, we report the clinical aspects, diagnosis, treatment and follow-up of five female patients with localized laryngeal amyloidosis without systemic involvement. The patients were all treated successfully using microlaryngoscopy with CO2 laser or cold instruments. Prognosis is excellent; however, appropriate follow-up is an important part of the long-term management of this disease in order to prevent and control the possibility of local recurrence.

Primary Localized Laryngeal Amyloidosis (LA)

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 4596-4596
Author(s):  
Matthew Richards ◽  
Kim Le ◽  
Mercedes Lorenzo-Medina ◽  
Langsjoen Dane ◽  
Carmen Arango ◽  
...  
Keyword(s):  
Vocal Cord ◽  
Conflicts Of Interest ◽  
Polarized Light ◽  
Rare Condition ◽  
B Cell Lymphoma ◽  
Laryngeal Amyloidosis ◽  
The Right ◽  
False Vocal ◽  
Localized Laryngeal Amyloidosis

Abstract Abstract 4596 Background: Localized Laryngeal Amyloidosis (LA) is a rare condition. There is limited understanding of its natural history. Our aim is to report the clinical evolution of a patient diagnosed with localized LA. Methods: Case report. Results: In May 2002, a 43-year-old gentleman presented with hoarseness and a CT scan of the neck showed a thickening of the right vocal cord with a mass that measured 2.9 × 1.2 cm in widest diameter. The patient had this mass removed surgically and the pathology showed a positive Congo red staining and a positive birefringence under polarized light, diagnostic of amyloidosis. No evidence of systemic amyloidosis or an overt B-cell lymphoma was found in this patient. Patient lost follow-up until October 2008 when he was found to have soft tissue induration around the left false vocal cord area. The biopsy showed again amyloidosis. Conclusions: LA recurrences can manifest several years after initial diagnosis. Long-term follow-up is essential. Disclosures: No relevant conflicts of interest to declare.

Primary Localized Laryngeal Amyloidosis: Report of 3 Cases With Long-term Follow-up and Review of the Literature

2005 ◽  
Vol 129 (2) ◽  
pp. 215-218 ◽  
Author(s):  
Linglei Ma ◽  
Bizhan Bandarchi ◽  
Clarence Sasaki ◽  
Steven Levine ◽  
Young Choi
Keyword(s):  
Light Chain ◽  
Plasma Cells ◽  
Anterior Commissure ◽  
B Cell Lymphoma ◽  
Plasma Cell Dyscrasia ◽  
Laryngeal Amyloidosis ◽  
Long Term Follow Up ◽  
Localized Laryngeal Amyloidosis

Abstract Context.—Localized laryngeal amyloidosis is an uncommon condition with limited long-term follow-up studies. The precise etiology and pathogenesis are not entirely clear. Objective.—To further characterize the histopathologic features and possible pathogenesis of localized laryngeal amyloidosis. Design.—Three cases of primary localized laryngeal amyloidosis were identified at our institutions from 1980 to 2003. The clinical features and histologic and immunohistochemical patterns were evaluated. Systemic workups were pursued during the long-term follow-up. Results.—The common presentation of the patients was hoarseness. The lesions involved vocal cords, anterior commissure, and ventricle. Microscopically, the amyloid was present within the submucosa with an adjacent lymphoplasmacytic infiltrate. The plasma cells and amyloid demonstrated monoclonal light chain restriction in all 3 cases (2 λ, 1 κ). No evidence of systemic amyloidosis or an overt B-cell lymphoma was found in these patients. Two patients with long-term follow-up underwent subsequent surgical removals for multiple recurrences, which occurred within 1 year of the initial diagnosis. Conclusions.—The demonstration of monoclonal light chain expression in the plasmacytic infiltrate and amyloid component in the absence of systemic lymphomas indicates that localized laryngeal amyloidosis may represent a form of benign monoclonal plasma cell dyscrasia. A close follow-up of the patients may be indicated for early detection of recurrences.

scholarly journals Human taeniasis infection (Taenia saginata): a complex public health problem. Case report

Case reports ◽  
2020 ◽  
Vol 6 (1) ◽  
pp. 8-16
Author(s):  
Shirley Natali Iza ◽  
José Alejandro Iza ◽  
Julián Felipe Porras-Villamil ◽  
Mario Javier Olivera
Keyword(s):  
Public Health Problem ◽  
Clinical Aspects ◽  
Taenia Saginata ◽  
Scientific Review ◽  
Prevention Education ◽  
Combination Drugs ◽  
Multiple Treatments ◽  
And Control

Introduction: Taeniasis is a zoonosis that can be found worldwide. It is relatively easy to diagnose and its treatment is currently effective. This paper describes the follow-up of a case with persistent refractory taeniasis.Case description: A 31-year-old female patient, street-food seller, was diagnosed with taeniasis when she was 21 years old. Since she was diagnosed, multiple treatments were administered, including albendazole, secnidazole, pirantel pamoato and several metronidazole schemes, which resulted in a partial improvement of the symptoms. In 2018, she expelled a parasite of ~1 meter in length, later described as Taenia saginata; praziquantel was prescribed, but it is not available in Colombia. The patient was referred to the Parasitology Service, and based on her medical history and a scientific review of literature, nitazoxanide (500mg, twice a day, for 3 days) and albendazole (400mg per day, for 3 days) were administered, eliminating the infection and improving the patient’s quality of life.Discussion: This case exposes two important clinical aspects. The first is the difficulty of monitoring and treating taeniasis cases. The second is the presence of persistent refractory taeniasis cases.Conclusion: Secondary, tertiary and combination drugs are available for effective and safe treatment of taeniasis. However, there is a need to conduct further studies to achieve better diagnosis, prevention, education and control.

scholarly journals Long-term follow-up after surgery in localized laryngeal amyloidosis

2016 ◽  
Vol 273 (9) ◽  
pp. 2613-2620 ◽  
Author(s):  
Aldert J. C. Hazenberg ◽  
Bouke P. C. Hazenberg ◽  
Frederik G. Dikkers
Keyword(s):  
Laryngeal Amyloidosis ◽  
Long Term Follow Up ◽  
Localized Laryngeal Amyloidosis

scholarly journals DLE Progressing to Squamous Cell Carcinoma: A Case Report

2016 ◽  
Vol 14 (1) ◽  
pp. 51-55
Author(s):  
S. Karki ◽  
A.K. Jha
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lupus Erythematosus ◽  
Histopathological Examination ◽  
Clinical Aspects ◽  
Discoid Lupus Erythematosus ◽  
Treatment Gap ◽  
Systemic Involvement

A 90 years female diagnosed as a case of Discoid lupus erythematosus (DLE) developed Squamous cell carcinoma from the lesions over a period of 5 years due to treatment gap and late follow up. Diagnosis was based on clinical aspects (erythematous, nodular and scanty bleeding), dermoscopic features and histopathological examination, the absence of systemic involvement and routine laboratory parameters, which registered all within normal range.SCC in a patient with DLE is rare in Nepalese patients. It is every essential to counsel the diagnosed cases of DLE and warn all patients about all the possible outcomes and compliance with medications should be ensured.Nepal Journal of Dermatology, Venereology & Leprology, Vol.14(1) 2016, pp.51-55

scholarly journals Primary Laryngeal Amyloidosis and CO2 Laser as the Treatment Modality

2021 ◽  
Vol 29 (2) ◽  
pp. 119-124
Author(s):  
Kriti Bhujel ◽  
Nilanjan Bhowmick ◽  
Sachin Gandhi ◽  
Harishankar Sharma ◽  
Deepshikha Mishra
Keyword(s):  
Clinical Features ◽  
Co2 Laser ◽  
Treatment Modality ◽  
Amyloid Fibrils ◽  
Anterior Commissure ◽  
Normal Function ◽  
Systemic Involvement ◽  
Primary Treatment Modality ◽  
Laryngeal Amyloidosis

Introduction Amyloidosis is brought about by intracellular and/or extracellular accumulation of insoluble abnormal amyloid fibrils that alters the normal function of the tissues. Localized laryngeal amyloidosis is a rare disease which lacks long-term follow-up studies. It is prone to recurrence; hence meticulous excision is required. We are doing this study to analyse clinical features of primary laryngeal amyloidosis, the subsites commonly found in, and the effectiveness of CO2 laser as treatment modality. Materials and Methods It is a retrospective study of 13 patients diagnosed as Primary Laryngeal Amyloidosis in between 2005 to 2018, where clinical features, histologic and immuno-histochemical patterns of the patients were evaluated. Systemic amyloidosis was ruled out by the non-appearance of Bence-Jones proteins in urine and serum electrophoresis examination. Systemic workups were pursued during the follow-up. The patients were followed up 3 monthly for the first year, then 6 monthly after that, for 3 years. The last patient who underwent the surgery was in the 2018 and had just finished his 2nd follow up, while the rest have been followed up for 3 years. Results Hoarseness was the most common complaint in all the patients. The subsites most common for amyloid deposition were seen in the true vocal cords followed by supraglottis, anterior commissure, ventricle and the subglottis. Microscopically, the amyloid was deposited within the submucosa surrounded by lymphoplamocytic infiltration. All cases were treated with microlaryngoscopic CO2 Laser excision. With the exception of one patient, the rest had no recurrence. Conclusion Primary Laryngeal Amyloidosis is an uncommon benign disease that has a predisposition for recurrence. With use of CO2 laser as the primary treatment modality, the percentage of recurrence has drastically reduced. Systemic involvement should be ruled out. A frequent follow-up of the patients is desirable for early detection of recurrences. Laser is a novel treatment of laryngeal amyloidosis.

scholarly journals Retrospective evaluation of the survival rate of single tooth prostheses supported in external hexagonal implants: mean follow-up of 9 years

2018 ◽  
Vol 47 (5) ◽  
pp. 328-332
Author(s):  
Carolina Accorsi CARTELLI ◽  
Ivete Aparecida de Mattias SARTORI ◽  
Geninho THOMÉ ◽  
Ana Cláudia Moreira MELO
Keyword(s):  
Survival Rate ◽  
Systemic Disease ◽  
Survival Rates ◽  
Implant Design ◽  
High Survival ◽  
Systemic Involvement ◽  
Design Type ◽  
Prosthesis Material ◽  
Prosthetic Complications

Abstract Introduction The use of osseointegrated dental implants for the rehabilitation of patients has revolutionized dentistry. Objective To retrospectively evaluate the survival rate and the frequency of complications with external hexagon platform supporting single crowns. Material and method Dental forms of 110 patients who received 143 implants at the Ilapeo College (2004-2015) were used. The variables were: age, gender, systemic involvement at the time of surgery, region, implant design, type of surface, fixation system, pillar type and prosthesis material. The outcome variables were the incidence of complications in the implant or prosthesis and time in use. The mean follow-up period was 9 years. Result 32.8% had some systemic disease. Ninety-six implants (67.1%) were installed in the maxilla and 47 (32.9%) in the mandible, 87 (60.8%) were in the posterior region and 56 (39.2%) in the anterior region, while 40 (28%) were placed in regions that had received bone reconstruction. The majority (97.2%) of the implants presented surface treatment, 42% had a cylindrical design and 58% were tapered. The majority of the prosthetic components (89.6%) used were UCLAs and most of the prostheses were fused-to-metal (79.7%). The rate of prosthetic complications was 19.58% and three implants had been lost (97.9% survival rate). There was no statistical difference between the variables analyzed for both the occurrence of prosthetic complications and for the loss of the implant. Conclusion Implants with external hexagon connection were an effective and predictable option to support crowns and had high survival rates.

Research Participation Experiences of Informants of Suicide and Control Cases

Crisis ◽  
2010 ◽  
Vol 31 (5) ◽  
pp. 238-246 ◽  
Author(s):  
Paul W. C. Wong ◽  
Wincy S. C. Chan ◽  
Philip S. L. Beh ◽  
Fiona W. S. Yau ◽  
Paul S. F. Yip ◽  
...  
Keyword(s):  
Ethical Issues ◽  
Research Participation ◽  
Self Report ◽  
Initial Contact ◽  
Psychological Autopsy ◽  
Autopsy Study ◽  
The People ◽  
And Control ◽  
The Impact

Background: Ethical issues have been raised about using the psychological autopsy approach in the study of suicide. The impact on informants of control cases who participated in case-control psychological autopsy studies has not been investigated. Aims: (1) To investigate whether informants of suicide cases recruited by two approaches (coroners’ court and public mortuaries) respond differently to the initial contact by the research team. (2) To explore the reactions, reasons for participation, and comments of both the informants of suicide and control cases to psychological autopsy interviews. (3) To investigate the impact of the interviews on informants of suicide cases about a month after the interviews. Methods: A self-report questionnaire was used for the informants of both suicide and control cases. Telephone follow-up interviews were conducted with the informants of suicide cases. Results: The majority of the informants of suicide cases, regardless of the initial route of contact, as well as the control cases were positive about being approached to take part in the study. A minority of informants of suicide and control cases found the experience of talking about their family member to be more upsetting than expected. The telephone follow-up interviews showed that none of the informants of suicide cases reported being distressed by the psychological autopsy interviews. Limitations: The acceptance rate for our original psychological autopsy study was modest. Conclusions: The findings of this study are useful for future participants and researchers in measuring the potential benefits and risks of participating in similar sensitive research. Psychological autopsy interviews may be utilized as an active engagement approach to reach out to the people bereaved by suicide, especially in places where the postvention work is underdeveloped.

Obesity management through Ayurveda - A Case Study

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Dheeraj Kumar Tyagi ◽  
Shivakumar .
Keyword(s):  
Clinical Findings ◽  
Dietary Habit ◽  
Unhealthy Lifestyle ◽  
Lifestyle Management ◽  
Before And After ◽  
Effect Of Treatment ◽  
And Control

Lifestyle disorders are one of the biggest threats for the population living unhealthy lifestyle. Sthoulya (Obesity) is one such disorder which creates lot of physical as well as mental disorder to the sufferer. Due to changing lifestyle, comforts and dietary habit lots of individuals changed their life totally. Obesity is a growing disease in developed and developing countries. Prevalence is drastically hike in past few years. Ayurveda, the science of life with which we can manage and control lots of lifestyle disorders. Focusing on dietary and lifestyle management along with treatment, we can overcome the hazards of obesity which is growing in a uncontrolled manner. The available data is based on the clinical findings only. Aim and objective: To assess the effect of “Guru Cha Atarpanam Chikitsa” in the management of Sthoulya. Setting: Swastharakshana evam Yoga, OPD and IPD, SDMCAH, Hassan. Method: Udwarthana, Parisheka, Shamana Aushadhis, Ahara, and Vihara was followed within the treatment duration and effect of treatment was assessed before and after treatment, advised for follow up. Results: The treatment adopted is effective in the management of Sthoulya and to improve the quality of life.

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